Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Objective Using centralized registries in Iceland, the aim of this study was to prospectively investigate multiple risk factors for renal cell carcinoma (RCC), including occupational history...
Published in: | Scandinavian Journal of Urology |
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Online Access: | http://hdl.handle.net/2336/613338 https://doi.org/10.3109/21681805.2016.1151460 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/613338 2023-05-15T16:49:08+02:00 Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. Mariusdottir, Elin Ingimarsson, Johann P Jonsson, Eirikur Einarsson, Gudmundur V Aspelund, Thor Gudnason, Vilmundur Gudbjartsson, Tomas 1 Landspitali Univ Hosp, Dept Urol, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital 2 Univ Iceland, Fac Med, Reykjavik, Iceland 3 Univ Iceland, Iceland Heart Assoc, Reykjavik, Iceland 2016 http://hdl.handle.net/2336/613338 https://doi.org/10.3109/21681805.2016.1151460 en eng Taylor & Francis Ltd http://dx.doi.org/ 10.3109/21681805.2016.1151460 Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. 2016, 50 (3):181-5 Scand J Urol 2168-1813 26999634 doi:10.3109/21681805.2016.1151460 http://hdl.handle.net/2336/613338 Scandinavian journal of urology Archived with thanks to Scandinavian journal of urology Closed - Lokað Nýrnafrumukrabbamein Atvinna Umhverfisáhrif Áhættumat URO12 TAS12 Occupations Environment Prospective Studies Carcinoma Renal Cell Risk Factors Article 2016 ftlandspitaliuni https://doi.org/10.3109/21681805.2016.1151460 2022-05-29T08:22:10Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page Objective Using centralized registries in Iceland, the aim of this study was to prospectively investigate multiple risk factors for renal cell carcinoma (RCC), including occupational history. Materials and methods From the Reykjavik study database, 18,840 men and women born in the period 1907-1935 were linked with a population-based registry containing all RCCs diagnosed in Iceland from 1971 to 2005 (n = 910). From this cross-reference, altogether 225 cases were identified. A prospective analysis of the risk factors for RCC was performed using Cox regression analysis, from the time of entry into the Reykjavik study to the diagnosis of RCC, death or end of follow-up, with a median follow-up time of 25 years. The hazard ratio (HR) was then calculated for multiple risk factors including occupational history. Results Male gender [HR 1.65, 95% confidence interval (CI) 1.14-2.38], body mass index (BMI) over 25 kg/m² (HR 1.41, 95% CI 1.06-1.88) and age (HR 1.04, 95% CI 1.03-1.07) increased the risk of RCC, as did severe hypertension (>160/100 mmHg) (HR 1.46, 95% CI 1.05-2.03) and history of kidney disease (HR 1.55, 95% CI 1.11-2.16); however, smoking and type 2 diabetes were not significantly associated with the disease. The risk of RCC was significantly increased in painters (HR 2.97, 95% CI 1.31-6.74), aircraft mechanics (HR 4.51, 95% CI 1.11-18.28) and shipbuilders (HR 2.03, 95% CI 1.06-3.84). Conclusions Together with male gender, advanced age, hypertension, BMI over 25 kg/m² and history of kidney disease, the risk of RCC was significantly increased in painters, aircraft mechanics and shipbuilders, suggesting a link to occupational exposure. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Urology 50 3 181 185 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
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English |
topic |
Nýrnafrumukrabbamein Atvinna Umhverfisáhrif Áhættumat URO12 TAS12 Occupations Environment Prospective Studies Carcinoma Renal Cell Risk Factors |
spellingShingle |
Nýrnafrumukrabbamein Atvinna Umhverfisáhrif Áhættumat URO12 TAS12 Occupations Environment Prospective Studies Carcinoma Renal Cell Risk Factors Mariusdottir, Elin Ingimarsson, Johann P Jonsson, Eirikur Einarsson, Gudmundur V Aspelund, Thor Gudnason, Vilmundur Gudbjartsson, Tomas Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
topic_facet |
Nýrnafrumukrabbamein Atvinna Umhverfisáhrif Áhættumat URO12 TAS12 Occupations Environment Prospective Studies Carcinoma Renal Cell Risk Factors |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Objective Using centralized registries in Iceland, the aim of this study was to prospectively investigate multiple risk factors for renal cell carcinoma (RCC), including occupational history. Materials and methods From the Reykjavik study database, 18,840 men and women born in the period 1907-1935 were linked with a population-based registry containing all RCCs diagnosed in Iceland from 1971 to 2005 (n = 910). From this cross-reference, altogether 225 cases were identified. A prospective analysis of the risk factors for RCC was performed using Cox regression analysis, from the time of entry into the Reykjavik study to the diagnosis of RCC, death or end of follow-up, with a median follow-up time of 25 years. The hazard ratio (HR) was then calculated for multiple risk factors including occupational history. Results Male gender [HR 1.65, 95% confidence interval (CI) 1.14-2.38], body mass index (BMI) over 25 kg/m² (HR 1.41, 95% CI 1.06-1.88) and age (HR 1.04, 95% CI 1.03-1.07) increased the risk of RCC, as did severe hypertension (>160/100 mmHg) (HR 1.46, 95% CI 1.05-2.03) and history of kidney disease (HR 1.55, 95% CI 1.11-2.16); however, smoking and type 2 diabetes were not significantly associated with the disease. The risk of RCC was significantly increased in painters (HR 2.97, 95% CI 1.31-6.74), aircraft mechanics (HR 4.51, 95% CI 1.11-18.28) and shipbuilders (HR 2.03, 95% CI 1.06-3.84). Conclusions Together with male gender, advanced age, hypertension, BMI over 25 kg/m² and history of kidney disease, the risk of RCC was significantly increased in painters, aircraft mechanics and shipbuilders, suggesting a link to occupational exposure. |
author2 |
1 Landspitali Univ Hosp, Dept Urol, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital 2 Univ Iceland, Fac Med, Reykjavik, Iceland 3 Univ Iceland, Iceland Heart Assoc, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Mariusdottir, Elin Ingimarsson, Johann P Jonsson, Eirikur Einarsson, Gudmundur V Aspelund, Thor Gudnason, Vilmundur Gudbjartsson, Tomas |
author_facet |
Mariusdottir, Elin Ingimarsson, Johann P Jonsson, Eirikur Einarsson, Gudmundur V Aspelund, Thor Gudnason, Vilmundur Gudbjartsson, Tomas |
author_sort |
Mariusdottir, Elin |
title |
Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
title_short |
Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
title_full |
Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
title_fullStr |
Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
title_full_unstemmed |
Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
title_sort |
occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. |
publisher |
Taylor & Francis Ltd |
publishDate |
2016 |
url |
http://hdl.handle.net/2336/613338 https://doi.org/10.3109/21681805.2016.1151460 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/ 10.3109/21681805.2016.1151460 Occupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. 2016, 50 (3):181-5 Scand J Urol 2168-1813 26999634 doi:10.3109/21681805.2016.1151460 http://hdl.handle.net/2336/613338 Scandinavian journal of urology |
op_rights |
Archived with thanks to Scandinavian journal of urology Closed - Lokað |
op_doi |
https://doi.org/10.3109/21681805.2016.1151460 |
container_title |
Scandinavian Journal of Urology |
container_volume |
50 |
container_issue |
3 |
container_start_page |
181 |
op_container_end_page |
185 |
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1766039217940463616 |