C-Reactive Protein and Resistance Exercise in Community Dwelling Old Adults.

• Published in: The journal of nutrition, health & aging
• Main Authors: Ramel, A, Geirsdottir, O G, Jonsson, P V, Thorsdottiri, I
• Other Authors: 1 Univ Iceland, Natl Univ Hosp Iceland, Unit Nutr Res, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital University of Iceland 2 Univ Iceland, Fac Food Sci & Nutr, Reykjavik, Iceland 3 Natl Univ Hosp Iceland, Icelandic Gerontol Res Ctr, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital 4 Fac Med, Reykjavik, Iceland 5 Natl Univ Hosp Iceland, Dept Geriatr, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer 2015
• Subjects: Aldraðir; Líkamsþjálfun; Æðakölkun; C-Reactive Protein; Resistance Training; Aged; 80 and over; Atherosclerosis; Early Medical Intervention; Iceland
• Online Access: http://hdl.handle.net/2336/577247; https://doi.org/10.1007/s12603-015-0548-2

To access publisher's full text version of this article click on the hyperlink at the bottom of the page C-reactive protein (CRP), an acute phase reactant, has been associated with atherosclerosis and has also been discussed as a target for intervention. The effects of resistance exercise on CRP are currently not clear. The present analysis investigated the response of CRP to resistance exercise in old adults. Intervention study. Community. Old Icelandic adults (N = 235, 73.7 ± 5.7 years, 58.2% female). Twelve-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum) designed to increase strength and muscle mass of major muscle groups. C-reactive protein (CRP). Mean CRP levels were 7.1 ± 4.6 mg/dL at baseline, thirty-six (15.6%) subjects had abnormally high CRP (>10 mg/L) values at baseline. After the resistance exercise program the overall changes in CRP were minor and not significant. However, CRP decreased considerably in participants with high CRP at baseline (-4.28 ± 9.41 mg/L; P = 0.015) but increased slightly in participants with normal CRP (0.81 ± 4.58 mg/L, P = 0.021). Our study shows that the concentrations of circulating CRP decreased considerably after a 12-week resistance exercise program in participants with abnormally high CRP at baseline, possibly reducing thus risk for future disease. CRP changed little in participants with normal CRP at the start of the study. Icelandic Technology Development Fund 071323008 University of Iceland Landspitali University Hospital Research Fund Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund