Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.

• Published in: Chemical Communications
• Main Authors: Sahariah, Priyanka, Sørensen, Kasper K, Hjálmarsdóttir, Martha Á, Sigurjónsson, Ólafur E, Jensen, Knud J, Másson, Már, Thygesen, Mikkel B
• Other Authors: 1 Univ Iceland, Sch Hlth Sci, Fac Pharmaceut Sci, IS-107 Reykjavik, Iceland 2 Univ Copenhagen, Ctr Carbohydrate Recognit & Signalling, Dept Chem, Fac Sci, DK-1871 Copenhagen, Denmark 3 Univ Iceland, Fac Med, Dept Biomed Sci, IS-101 Reykjavik, Iceland 4 Landspitali Univ Hosp, REModeL Lab, Blood Bank, IS-105 Reykjavik, Iceland 5 Reykjavik Univ, Inst Biomed & Neural Engn, IS-105 Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Royal Soc Chemistry 2015
• Subjects: Antimicrobial Cationic Peptides/chemical synthesis; Antimicrobial Cationic Peptides/pharmacology*; Iceland
• Online Access: http://hdl.handle.net/2336/575053; https://doi.org/10.1039/c5cc04010h

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan. Danish National Research Foundation DNRF79 Icelandic Research Fund 120443021 University of Iceland Research Fund