Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activi...
Published in: | Chemical Communications |
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Main Authors: | , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Royal Soc Chemistry
2015
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Subjects: | |
Online Access: | http://hdl.handle.net/2336/575053 https://doi.org/10.1039/c5cc04010h |
Summary: | To access publisher's full text version of this article click on the hyperlink at the bottom of the page Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan. Danish National Research Foundation DNRF79 Icelandic Research Fund 120443021 University of Iceland Research Fund |
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