Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page High adiposity in midlife might increase risk for late-life brain pathology, including dementia. Using data from the prospective Age, Gene/Environment Susceptibility-Reykjavik Study of men a...
Published in: | American Journal of Epidemiology |
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Online Access: | http://hdl.handle.net/2336/566195 https://doi.org/10.1093/aje/kwu331 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/566195 2023-05-15T16:51:49+02:00 Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. Albanese, Emiliano Davis, Benjamin Jonsson, Palmi V Chang, Milan Aspelund, Thor Garcia, Melissa Harris, Tamara Gudnason, Vilmundur Launer, Lenore J 2015 http://hdl.handle.net/2336/566195 https://doi.org/10.1093/aje/kwu331 en eng Oxford Univ Press http://dx.doi.org/ 10.1093/aje/kwu331 http://aje.oxfordjournals.org/content/181/9/672.full.pdf Am. J. Epidemiol. 2015, 181 (9):672-9 1476-6256 25810457 doi:10.1093/aje/kwu331 http://hdl.handle.net/2336/566195 American journal of epidemiology Archived with thanks to American journal of epidemiology Landspitali Access - LSH-aðgangur Aldraðir Offita Elliglöp Heilablóðfall Líkamsþyngd Miðaldra fólk Aged 80 and over Body Mass Index Brain Brain Infarction Cerebral Hemorrhage Dementia Female Follow-Up Studies Humans Iceland Magnetic Resonance Imaging Male Middle Aged Obesity Article 2015 ftlandspitaliuni https://doi.org/10.1093/aje/kwu331 2022-05-29T08:22:06Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page High adiposity in midlife might increase risk for late-life brain pathology, including dementia. Using data from the prospective Age, Gene/Environment Susceptibility-Reykjavik Study of men and women (born 1907-1935), we studied the associations of overweight and obesity at midlife (mean age, 50 (standard deviation, 4.7) years) with 1.5-T brain magnetic resonance imaging measures of infarct-like brain lesions, cerebral microbleeds, total brain volume, and white matter lesions volume, as well as dementia, in late life (mean age, 76 (standard deviation, 5.2) years). We used linear and Poisson models to estimate associations in 3,864 persons after adjustment for sociodemographic, health, and lifestyle characteristics. In midlife, the prevalence of overweight was 39% and that of obesity was 8%. After a mean follow-up of 26.2 (standard deviation, 4.9) years, midlife overweight and obesity were not associated with infarct-like brain lesions (relative risk (RR) = 0.82, 95% confidence interval (CI): 0.61, 1.10), cerebral microbleeds (RR = 0.69, 95% CI: 0.37, 1.32), total brain volume (β = 0.05, 95% CI: -0.34, 0.45), white matter lesions volume (β = -0.10, 95% CI: -0.20, 0.01), or dementia (RR = 0.91, 95% CI: 0.49, 1.72) compared with normal weight. These findings do not support the hypothesis that high body mass index in midlife modulates the risk for dementia. National Institutes of Health N01-AG-12100 National Institute on Aging Intramural Research Program Icelandic Heart Association Icelandic Parliament Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive American Journal of Epidemiology 181 9 672 679 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aldraðir Offita Elliglöp Heilablóðfall Líkamsþyngd Miðaldra fólk Aged 80 and over Body Mass Index Brain Brain Infarction Cerebral Hemorrhage Dementia Female Follow-Up Studies Humans Iceland Magnetic Resonance Imaging Male Middle Aged Obesity |
spellingShingle |
Aldraðir Offita Elliglöp Heilablóðfall Líkamsþyngd Miðaldra fólk Aged 80 and over Body Mass Index Brain Brain Infarction Cerebral Hemorrhage Dementia Female Follow-Up Studies Humans Iceland Magnetic Resonance Imaging Male Middle Aged Obesity Albanese, Emiliano Davis, Benjamin Jonsson, Palmi V Chang, Milan Aspelund, Thor Garcia, Melissa Harris, Tamara Gudnason, Vilmundur Launer, Lenore J Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. |
topic_facet |
Aldraðir Offita Elliglöp Heilablóðfall Líkamsþyngd Miðaldra fólk Aged 80 and over Body Mass Index Brain Brain Infarction Cerebral Hemorrhage Dementia Female Follow-Up Studies Humans Iceland Magnetic Resonance Imaging Male Middle Aged Obesity |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page High adiposity in midlife might increase risk for late-life brain pathology, including dementia. Using data from the prospective Age, Gene/Environment Susceptibility-Reykjavik Study of men and women (born 1907-1935), we studied the associations of overweight and obesity at midlife (mean age, 50 (standard deviation, 4.7) years) with 1.5-T brain magnetic resonance imaging measures of infarct-like brain lesions, cerebral microbleeds, total brain volume, and white matter lesions volume, as well as dementia, in late life (mean age, 76 (standard deviation, 5.2) years). We used linear and Poisson models to estimate associations in 3,864 persons after adjustment for sociodemographic, health, and lifestyle characteristics. In midlife, the prevalence of overweight was 39% and that of obesity was 8%. After a mean follow-up of 26.2 (standard deviation, 4.9) years, midlife overweight and obesity were not associated with infarct-like brain lesions (relative risk (RR) = 0.82, 95% confidence interval (CI): 0.61, 1.10), cerebral microbleeds (RR = 0.69, 95% CI: 0.37, 1.32), total brain volume (β = 0.05, 95% CI: -0.34, 0.45), white matter lesions volume (β = -0.10, 95% CI: -0.20, 0.01), or dementia (RR = 0.91, 95% CI: 0.49, 1.72) compared with normal weight. These findings do not support the hypothesis that high body mass index in midlife modulates the risk for dementia. National Institutes of Health N01-AG-12100 National Institute on Aging Intramural Research Program Icelandic Heart Association Icelandic Parliament |
format |
Article in Journal/Newspaper |
author |
Albanese, Emiliano Davis, Benjamin Jonsson, Palmi V Chang, Milan Aspelund, Thor Garcia, Melissa Harris, Tamara Gudnason, Vilmundur Launer, Lenore J |
author_facet |
Albanese, Emiliano Davis, Benjamin Jonsson, Palmi V Chang, Milan Aspelund, Thor Garcia, Melissa Harris, Tamara Gudnason, Vilmundur Launer, Lenore J |
author_sort |
Albanese, Emiliano |
title |
Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. |
title_short |
Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. |
title_full |
Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. |
title_fullStr |
Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. |
title_full_unstemmed |
Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study. |
title_sort |
overweight and obesity in midlife and brain structure and dementia 26 years later: the ages-reykjavik study. |
publisher |
Oxford Univ Press |
publishDate |
2015 |
url |
http://hdl.handle.net/2336/566195 https://doi.org/10.1093/aje/kwu331 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/ 10.1093/aje/kwu331 http://aje.oxfordjournals.org/content/181/9/672.full.pdf Am. J. Epidemiol. 2015, 181 (9):672-9 1476-6256 25810457 doi:10.1093/aje/kwu331 http://hdl.handle.net/2336/566195 American journal of epidemiology |
op_rights |
Archived with thanks to American journal of epidemiology Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1093/aje/kwu331 |
container_title |
American Journal of Epidemiology |
container_volume |
181 |
container_issue |
9 |
container_start_page |
672 |
op_container_end_page |
679 |
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1766041928904736768 |