The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. The observed low metastatic potential and favorable survival of small incidentally detecte...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/552286 2023-05-15T16:49:08+02:00 The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. Ingimarsson, Johann P Sigurdsson, Martin I Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas Dept Urol, Memphis, TN USA, Dept Surg, Memphis, TN USA, Landspitali Univ Hosp, Reykjavik, Iceland, Univ Iceland, Fac Med, Reykjavik, Iceland, Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA 2015 http://hdl.handle.net/2336/552286 http://dx.doi.org/ 10.1186/1471-2490-14-72 en eng BioMed Central Ltd http://dx.doi.org/ 1186/1471-2490-14-72 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159381/ BMC Urol. 2014, 14:72 1471-2490 25174263 http://dx.doi.org/ 10.1186/1471-2490-14-72 http://hdl.handle.net/2336/552286 BMC urology Archived with thanks to BMC urology Open Access Nýrnakrabbamein Carcinoma Renal Cell Disease-Free Survival Female Humans Iceland Kidney Neoplasms Male Multivariate Analysis Neoplasm Metastasis Nephrectomy Retrospective Studies Risk Factors Article 2015 ftlandspitaliuni 2022-05-29T08:22:03Z To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. The observed low metastatic potential and favorable survival of small incidentally detected renal cell carcinomas (RCCs) have been a part of the rationale for recommending partial nephrectomy as a first treatment option and active surveillance in selected patients. We examined the relationship between tumor size and the odds of synchronous metastases (SMs) (primary outcome) and disease specific survival (secondary outcome) in a nationwide RCC registry. Retrospective study of the 794 RCC patients diagnosed in Iceland between 1971 and 2005. Histological material and TNM staging were reviewed centrally. The presence of SM and survival were recorded. Cubic spline analysis was used to assess relationship between tumor size and probability of SM. Univariate and multivariate statistics were used to estimate prognostic factors for SM and survival. The probability of SM increased in a non-linear fashion with increasing tumor size (11, 25, 35, and 50%) for patients with tumors of ≤4, 4.1-7.0, 7.1-10.0, and >10 cm, respectively. On multivariate analysis, tumor size was an independent prognostic factor for disease-specific survival (HR = 1.05, 95% CI 1.02-1.09, p < 0.001), but not for SM. Tumor size affected the probability of disease-specific mortality but not SM, after correcting for TNM staging in multivariate analysis. This confirms the prognostic ability of the 2010 TNM staging system for renal cell cancer in the Icelandic population. Landspitali University Hospital Scientific Foundation Memorial Foundation of Bergthora Magnusdottir and Jakob J. Bjarnason Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Nýrnakrabbamein Carcinoma Renal Cell Disease-Free Survival Female Humans Iceland Kidney Neoplasms Male Multivariate Analysis Neoplasm Metastasis Nephrectomy Retrospective Studies Risk Factors |
spellingShingle |
Nýrnakrabbamein Carcinoma Renal Cell Disease-Free Survival Female Humans Iceland Kidney Neoplasms Male Multivariate Analysis Neoplasm Metastasis Nephrectomy Retrospective Studies Risk Factors Ingimarsson, Johann P Sigurdsson, Martin I Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
topic_facet |
Nýrnakrabbamein Carcinoma Renal Cell Disease-Free Survival Female Humans Iceland Kidney Neoplasms Male Multivariate Analysis Neoplasm Metastasis Nephrectomy Retrospective Studies Risk Factors |
description |
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. The observed low metastatic potential and favorable survival of small incidentally detected renal cell carcinomas (RCCs) have been a part of the rationale for recommending partial nephrectomy as a first treatment option and active surveillance in selected patients. We examined the relationship between tumor size and the odds of synchronous metastases (SMs) (primary outcome) and disease specific survival (secondary outcome) in a nationwide RCC registry. Retrospective study of the 794 RCC patients diagnosed in Iceland between 1971 and 2005. Histological material and TNM staging were reviewed centrally. The presence of SM and survival were recorded. Cubic spline analysis was used to assess relationship between tumor size and probability of SM. Univariate and multivariate statistics were used to estimate prognostic factors for SM and survival. The probability of SM increased in a non-linear fashion with increasing tumor size (11, 25, 35, and 50%) for patients with tumors of ≤4, 4.1-7.0, 7.1-10.0, and >10 cm, respectively. On multivariate analysis, tumor size was an independent prognostic factor for disease-specific survival (HR = 1.05, 95% CI 1.02-1.09, p < 0.001), but not for SM. Tumor size affected the probability of disease-specific mortality but not SM, after correcting for TNM staging in multivariate analysis. This confirms the prognostic ability of the 2010 TNM staging system for renal cell cancer in the Icelandic population. Landspitali University Hospital Scientific Foundation Memorial Foundation of Bergthora Magnusdottir and Jakob J. Bjarnason |
author2 |
Dept Urol, Memphis, TN USA, Dept Surg, Memphis, TN USA, Landspitali Univ Hosp, Reykjavik, Iceland, Univ Iceland, Fac Med, Reykjavik, Iceland, Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA |
format |
Article in Journal/Newspaper |
author |
Ingimarsson, Johann P Sigurdsson, Martin I Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas |
author_facet |
Ingimarsson, Johann P Sigurdsson, Martin I Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas |
author_sort |
Ingimarsson, Johann P |
title |
The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
title_short |
The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
title_full |
The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
title_fullStr |
The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
title_full_unstemmed |
The impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
title_sort |
impact of tumour size on the probability of synchronous metastasis and survival in renal cell carcinoma patients: a population-based study. |
publisher |
BioMed Central Ltd |
publishDate |
2015 |
url |
http://hdl.handle.net/2336/552286 http://dx.doi.org/ 10.1186/1471-2490-14-72 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
geographic |
TNM |
geographic_facet |
TNM |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/ 1186/1471-2490-14-72 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159381/ BMC Urol. 2014, 14:72 1471-2490 25174263 http://dx.doi.org/ 10.1186/1471-2490-14-72 http://hdl.handle.net/2336/552286 BMC urology |
op_rights |
Archived with thanks to BMC urology Open Access |
_version_ |
1766039215595847680 |