Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Objective: First to measure plasma HIV-1 RNA in Icelandic HIV infected individuals and second to evaluate the initial effects of new combination regimens on viral load and CD4+ cell counts in HIV infecte...
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Language: | Icelandic |
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Læknafélag Íslands, Læknafélag Reykjavíkur
2009
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Online Access: | http://hdl.handle.net/2336/49393 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/49393 2023-05-15T16:48:18+02:00 Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi Measurements of plasma HIV-1 RNA in Iceland Gunnar Gunnarsson Barbara M. Stanzeit Haraldur Briem Hugrún Ríkarðsdóttir Már Kristjánsson Sigurður Guðmundsson Sigurður B. Þorsteinsson Arthur Löve Rannsóknastofa Landspítalans í veirufræði, 2) lyflækningadeild Landspítalans, 3) smitsjúkdómadeild Sjúkrahúss Reykjavíkur. 2009-02-17 http://hdl.handle.net/2336/49393 is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is Læknablaðið 1998, 84(6):483-9 0023-7213 http://hdl.handle.net/2336/49393 Læknablaðið Alnæmi Lyfjameðferð HIV Infections HIV-1 Anti-HIV Agents Iceland Article 2009 ftlandspitaliuni 2022-05-29T08:21:16Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Objective: First to measure plasma HIV-1 RNA in Icelandic HIV infected individuals and second to evaluate the initial effects of new combination regimens on viral load and CD4+ cell counts in HIV infected patients in Iceland. Material and methods: The cohort studied consis¬ted of all HIV infected individuals we received samples from during the period September 1995 to November 1996. HIV-1 RNA and CD4+ cells were measured initially and subsequently every three to six months except when a change was made in the antiretroviral regimen, when samples were measured before the change, three to four weeks later and then every three to six months. The quantitative measurement of viral RNA was performed using the Amplicor HIV Monitor™ Test (Roche Diagnostic Sys¬tems). CD4+ cell counts were measured by flow cytometry. Results: A total of 44 patients were evaluated. The initial RNA ranged from < 2.6 logio to 6.13 logio with a mean of 5.02 log. CD4+ cell counts ranged from 2 to 641 per mm3 (mean 230 cells/mm3). Eleven patients had never been treated with antiretroviral drugs and had greater than 10 000 viral copies per mL of plasma. Twenty five of the patients were evaluated following a change in or initiation of a new treatment. The initial change in treatment led to a +0.7 to -2.88 log change in plasma RNA (mean -0.9 log) and a mean of 6.9 cells per mm3 increase in CD4+ cells. Saquinavir was added to two reverse transcriptase (RT) inhibitors in 11 patients with a resulting mean of 0.23 log fall in RNA levels (range +0.70 log to -0.78 log). Saquinavir plus one RT inhibitor were added to one RT inhibitor in six patients with a subsequent mean of 0.65 log reduction in viral load (range +0.24 to -2.26 log). Saquinavir plus two RT inhibitors were given to four antiretroviral naive patients with a resulting mean of 2.37 log reduction in viral load (range -1.8 log to -2.67 log). Conclusions: 1. In a mixed cohort of RT inhibitor ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Alnæmi Lyfjameðferð HIV Infections HIV-1 Anti-HIV Agents Iceland |
spellingShingle |
Alnæmi Lyfjameðferð HIV Infections HIV-1 Anti-HIV Agents Iceland Gunnar Gunnarsson Barbara M. Stanzeit Haraldur Briem Hugrún Ríkarðsdóttir Már Kristjánsson Sigurður Guðmundsson Sigurður B. Þorsteinsson Arthur Löve Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi |
topic_facet |
Alnæmi Lyfjameðferð HIV Infections HIV-1 Anti-HIV Agents Iceland |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Objective: First to measure plasma HIV-1 RNA in Icelandic HIV infected individuals and second to evaluate the initial effects of new combination regimens on viral load and CD4+ cell counts in HIV infected patients in Iceland. Material and methods: The cohort studied consis¬ted of all HIV infected individuals we received samples from during the period September 1995 to November 1996. HIV-1 RNA and CD4+ cells were measured initially and subsequently every three to six months except when a change was made in the antiretroviral regimen, when samples were measured before the change, three to four weeks later and then every three to six months. The quantitative measurement of viral RNA was performed using the Amplicor HIV Monitor™ Test (Roche Diagnostic Sys¬tems). CD4+ cell counts were measured by flow cytometry. Results: A total of 44 patients were evaluated. The initial RNA ranged from < 2.6 logio to 6.13 logio with a mean of 5.02 log. CD4+ cell counts ranged from 2 to 641 per mm3 (mean 230 cells/mm3). Eleven patients had never been treated with antiretroviral drugs and had greater than 10 000 viral copies per mL of plasma. Twenty five of the patients were evaluated following a change in or initiation of a new treatment. The initial change in treatment led to a +0.7 to -2.88 log change in plasma RNA (mean -0.9 log) and a mean of 6.9 cells per mm3 increase in CD4+ cells. Saquinavir was added to two reverse transcriptase (RT) inhibitors in 11 patients with a resulting mean of 0.23 log fall in RNA levels (range +0.70 log to -0.78 log). Saquinavir plus one RT inhibitor were added to one RT inhibitor in six patients with a subsequent mean of 0.65 log reduction in viral load (range +0.24 to -2.26 log). Saquinavir plus two RT inhibitors were given to four antiretroviral naive patients with a resulting mean of 2.37 log reduction in viral load (range -1.8 log to -2.67 log). Conclusions: 1. In a mixed cohort of RT inhibitor ... |
author2 |
Rannsóknastofa Landspítalans í veirufræði, 2) lyflækningadeild Landspítalans, 3) smitsjúkdómadeild Sjúkrahúss Reykjavíkur. |
format |
Article in Journal/Newspaper |
author |
Gunnar Gunnarsson Barbara M. Stanzeit Haraldur Briem Hugrún Ríkarðsdóttir Már Kristjánsson Sigurður Guðmundsson Sigurður B. Þorsteinsson Arthur Löve |
author_facet |
Gunnar Gunnarsson Barbara M. Stanzeit Haraldur Briem Hugrún Ríkarðsdóttir Már Kristjánsson Sigurður Guðmundsson Sigurður B. Þorsteinsson Arthur Löve |
author_sort |
Gunnar Gunnarsson |
title |
Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi |
title_short |
Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi |
title_full |
Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi |
title_fullStr |
Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi |
title_full_unstemmed |
Mælingar á magni alnæmisveiru í plasma HIV smitaðra á Íslandi |
title_sort |
mælingar á magni alnæmisveiru í plasma hiv smitaðra á íslandi |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/49393 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Smella |
geographic_facet |
Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is Læknablaðið 1998, 84(6):483-9 0023-7213 http://hdl.handle.net/2336/49393 Læknablaðið |
_version_ |
1766038409880535040 |