Operative mortality after nephrectomy for renal cell carcinoma
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To study the rate and causes of operative and treatment-related mortality after nephrectomy for renal cell carcinoma (RCC) in Iceland. MATERIAL AND METHODS: This retrospective po...
Published in: | Scandinavian Journal of Urology and Nephrology |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/4641 2023-05-15T16:46:56+02:00 Operative mortality after nephrectomy for renal cell carcinoma Thoroddsen, Asgeir Gudbjartsson, Tomas Jonsson, Eirikur Gislason, Thorsteinn Einarsson, Gudmundur Vikar 2003 YES http://hdl.handle.net/2336/4641 https://doi.org/10.1080/00365590310015732 en eng Taylor & Francis http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11692363&site=ehost-live Scand J Urol Nephrol 2003, 37(6):507-11 0036-5599 14675926 doi:10.1080/00365590310015732 URO12 http://hdl.handle.net/2336/4641 Survival Rate Statistics Nonparametric Sex Distribution Risk Assessment Research Support Non-U.S. Gov't Probability Nephrectomy Neoplasm Staging Middle Aged Male Kidney Neoplasms Iceland Hospital Mortality Carcinoma Renal Cell Age Distribution Article 2003 ftlandspitaliuni https://doi.org/10.1080/00365590310015732 2022-05-29T08:20:53Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To study the rate and causes of operative and treatment-related mortality after nephrectomy for renal cell carcinoma (RCC) in Iceland. MATERIAL AND METHODS: This retrospective population-based study included all patients who underwent nephrectomy for RCC in Iceland between 1971 and 2000. Patients who died <30 days after the operation were analyzed and compared to those who survived surgery. Disease stage, tumor size, patient age and preoperative American Society of Anesthesiologists classification were compared between the two groups. Autopsy records were examined to determine the causes of death. RESULTS: During the study period 880 patients were diagnosed with RCC and 575 (65%) of them underwent a nephrectomy, 116 (20%) with palliative intent. Operative mortality (OM) was 2.8% and did not change during the 30-year period. Patients with OM were significantly older than those without (73 vs 64 years, respectively) but disease stage, tumor size, ASA classification and gender were comparable between the groups. OM was comparable for patients operated on with palliative (3.4%) vs. curative (2.6%) intent (ns). Median time of death was 10 days postoperatively but no patient died intraoperatively. Causes of death were peri- and postoperative bleeding in five patients, infection/sepsis in four, arrhythmia in three, acute renal failure in two, pulmonary embolism in one and multiorgan failure in one. CONCLUSIONS: OM after nephrectomy for RCC has remained low during the past three decades in Iceland. It is most often caused by perioperative bleeding and infections. We find that the low OM in patients with metastases gives support to the use of palliative nephrectomy as a treatment option when other forms of treatment have failed. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Urology and Nephrology 37 6 507 511 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Survival Rate Statistics Nonparametric Sex Distribution Risk Assessment Research Support Non-U.S. Gov't Probability Nephrectomy Neoplasm Staging Middle Aged Male Kidney Neoplasms Iceland Hospital Mortality Carcinoma Renal Cell Age Distribution |
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Survival Rate Statistics Nonparametric Sex Distribution Risk Assessment Research Support Non-U.S. Gov't Probability Nephrectomy Neoplasm Staging Middle Aged Male Kidney Neoplasms Iceland Hospital Mortality Carcinoma Renal Cell Age Distribution Thoroddsen, Asgeir Gudbjartsson, Tomas Jonsson, Eirikur Gislason, Thorsteinn Einarsson, Gudmundur Vikar Operative mortality after nephrectomy for renal cell carcinoma |
topic_facet |
Survival Rate Statistics Nonparametric Sex Distribution Risk Assessment Research Support Non-U.S. Gov't Probability Nephrectomy Neoplasm Staging Middle Aged Male Kidney Neoplasms Iceland Hospital Mortality Carcinoma Renal Cell Age Distribution |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To study the rate and causes of operative and treatment-related mortality after nephrectomy for renal cell carcinoma (RCC) in Iceland. MATERIAL AND METHODS: This retrospective population-based study included all patients who underwent nephrectomy for RCC in Iceland between 1971 and 2000. Patients who died <30 days after the operation were analyzed and compared to those who survived surgery. Disease stage, tumor size, patient age and preoperative American Society of Anesthesiologists classification were compared between the two groups. Autopsy records were examined to determine the causes of death. RESULTS: During the study period 880 patients were diagnosed with RCC and 575 (65%) of them underwent a nephrectomy, 116 (20%) with palliative intent. Operative mortality (OM) was 2.8% and did not change during the 30-year period. Patients with OM were significantly older than those without (73 vs 64 years, respectively) but disease stage, tumor size, ASA classification and gender were comparable between the groups. OM was comparable for patients operated on with palliative (3.4%) vs. curative (2.6%) intent (ns). Median time of death was 10 days postoperatively but no patient died intraoperatively. Causes of death were peri- and postoperative bleeding in five patients, infection/sepsis in four, arrhythmia in three, acute renal failure in two, pulmonary embolism in one and multiorgan failure in one. CONCLUSIONS: OM after nephrectomy for RCC has remained low during the past three decades in Iceland. It is most often caused by perioperative bleeding and infections. We find that the low OM in patients with metastases gives support to the use of palliative nephrectomy as a treatment option when other forms of treatment have failed. |
format |
Article in Journal/Newspaper |
author |
Thoroddsen, Asgeir Gudbjartsson, Tomas Jonsson, Eirikur Gislason, Thorsteinn Einarsson, Gudmundur Vikar |
author_facet |
Thoroddsen, Asgeir Gudbjartsson, Tomas Jonsson, Eirikur Gislason, Thorsteinn Einarsson, Gudmundur Vikar |
author_sort |
Thoroddsen, Asgeir |
title |
Operative mortality after nephrectomy for renal cell carcinoma |
title_short |
Operative mortality after nephrectomy for renal cell carcinoma |
title_full |
Operative mortality after nephrectomy for renal cell carcinoma |
title_fullStr |
Operative mortality after nephrectomy for renal cell carcinoma |
title_full_unstemmed |
Operative mortality after nephrectomy for renal cell carcinoma |
title_sort |
operative mortality after nephrectomy for renal cell carcinoma |
publisher |
Taylor & Francis |
publishDate |
2003 |
url |
http://hdl.handle.net/2336/4641 https://doi.org/10.1080/00365590310015732 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11692363&site=ehost-live Scand J Urol Nephrol 2003, 37(6):507-11 0036-5599 14675926 doi:10.1080/00365590310015732 URO12 http://hdl.handle.net/2336/4641 |
op_doi |
https://doi.org/10.1080/00365590310015732 |
container_title |
Scandinavian Journal of Urology and Nephrology |
container_volume |
37 |
container_issue |
6 |
container_start_page |
507 |
op_container_end_page |
511 |
_version_ |
1766037036811157504 |