Localization of cortical cataract in subjects of diverse races and latitude
PURPOSE. To compare the characteristics of early cortical cataract localization in three groups in cataract epidemiologic surveys performed in Reykjavík, Melbourne, and Singapore. METHODS. Individuals who had right eyes with an area of cortical opacity less than 20% of the pupil when dilated 7 mm or...
Published in: | Investigative Opthalmology & Visual Science |
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Association For Research In Vision And Ophthalmology (Arvo)
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Online Access: | http://hdl.handle.net/2336/4630 https://doi.org/10.1167/iovs.01-1221 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/4630 2023-05-15T16:51:49+02:00 Localization of cortical cataract in subjects of diverse races and latitude Sasaki, Hiroshi Kawakami, Yutaka Ono, Masaji Jonasson, Fridbert Shui, Ying Bo Cheng, Hong-Ming Robman, Luba McCarty, Cathy Chew, Sek Jin Sasaki, Kazuyuki 2003-10-01 YES http://hdl.handle.net/2336/4630 https://doi.org/10.1167/iovs.01-1221 en eng Association For Research In Vision And Ophthalmology (Arvo) http://www.iovs.org/cgi/content/full/44/10/4210 Invest. Ophthalmol. Vis. Sci. 2003, 44(10):4210-4 0146-0404 14507863 doi:10.1167/iovs.01-1221 OPH12 http://hdl.handle.net/2336/4630 Aged 80 and over Cataract Climate Ethnic Groups Iceland/epidemiology Lens Cortex Crystalline Prevalence Radiation Injuries Research Support Non-U.S. Gov't Singapore/epidemiology Ultraviolet Rays Article 2003 ftlandspitaliuni https://doi.org/10.1167/iovs.01-1221 2022-05-29T08:20:53Z PURPOSE. To compare the characteristics of early cortical cataract localization in three groups in cataract epidemiologic surveys performed in Reykjavík, Melbourne, and Singapore. METHODS. Individuals who had right eyes with an area of cortical opacity less than 20% of the pupil when dilated 7 mm or more were selected as subjects. This included 197 subjects from the Reykjavík Eye Study, 231 from the Vitamin E, Cataract, and Age-Related Maculopathy (VECAT) study in Melbourne, and 92 from the Singapore-Japan Cooperative Cataract Study, all showing early-stage cataract in pupils dilated to 7 mm or more. Scheimpflug and retroilluminated photographs were used to locate opacities. Localization of cortical cataract was determined by dividing the retroillumination image into seven concentric circles with diameters of 1 through 7 mm, and eight sections of 45 degrees radial octants. The positive rate of opacification was then calculated for each quadrant. RESULTS. The highest positive rate of opacification was observed in the lower nasal quadrant in all groups. The relative risk of the prevalence of cortical opacity in the lower nasal oblique hemisphere to the upper temporal oblique hemisphere was the highest in the Singaporean subjects followed by those of Melbourne and then of Reykjavík. CONCLUSIONS. The prevalence of cortical cataract was higher in the lower nasal quadrant than in the other quadrants for all subjects of diverse race in three climatically different locations. This higher prevalence was most pronounced in subjects living at low latitude. These results support the view that solar UV exposure is a possible risk factor for development of human cortical cataract. Article in Journal/Newspaper Iceland Reykjavík Reykjavík Hirsla - Landspítali University Hospital research archive Reykjavík Investigative Opthalmology & Visual Science 44 10 4210 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Cataract Climate Ethnic Groups Iceland/epidemiology Lens Cortex Crystalline Prevalence Radiation Injuries Research Support Non-U.S. Gov't Singapore/epidemiology Ultraviolet Rays |
spellingShingle |
Aged 80 and over Cataract Climate Ethnic Groups Iceland/epidemiology Lens Cortex Crystalline Prevalence Radiation Injuries Research Support Non-U.S. Gov't Singapore/epidemiology Ultraviolet Rays Sasaki, Hiroshi Kawakami, Yutaka Ono, Masaji Jonasson, Fridbert Shui, Ying Bo Cheng, Hong-Ming Robman, Luba McCarty, Cathy Chew, Sek Jin Sasaki, Kazuyuki Localization of cortical cataract in subjects of diverse races and latitude |
topic_facet |
Aged 80 and over Cataract Climate Ethnic Groups Iceland/epidemiology Lens Cortex Crystalline Prevalence Radiation Injuries Research Support Non-U.S. Gov't Singapore/epidemiology Ultraviolet Rays |
description |
PURPOSE. To compare the characteristics of early cortical cataract localization in three groups in cataract epidemiologic surveys performed in Reykjavík, Melbourne, and Singapore. METHODS. Individuals who had right eyes with an area of cortical opacity less than 20% of the pupil when dilated 7 mm or more were selected as subjects. This included 197 subjects from the Reykjavík Eye Study, 231 from the Vitamin E, Cataract, and Age-Related Maculopathy (VECAT) study in Melbourne, and 92 from the Singapore-Japan Cooperative Cataract Study, all showing early-stage cataract in pupils dilated to 7 mm or more. Scheimpflug and retroilluminated photographs were used to locate opacities. Localization of cortical cataract was determined by dividing the retroillumination image into seven concentric circles with diameters of 1 through 7 mm, and eight sections of 45 degrees radial octants. The positive rate of opacification was then calculated for each quadrant. RESULTS. The highest positive rate of opacification was observed in the lower nasal quadrant in all groups. The relative risk of the prevalence of cortical opacity in the lower nasal oblique hemisphere to the upper temporal oblique hemisphere was the highest in the Singaporean subjects followed by those of Melbourne and then of Reykjavík. CONCLUSIONS. The prevalence of cortical cataract was higher in the lower nasal quadrant than in the other quadrants for all subjects of diverse race in three climatically different locations. This higher prevalence was most pronounced in subjects living at low latitude. These results support the view that solar UV exposure is a possible risk factor for development of human cortical cataract. |
format |
Article in Journal/Newspaper |
author |
Sasaki, Hiroshi Kawakami, Yutaka Ono, Masaji Jonasson, Fridbert Shui, Ying Bo Cheng, Hong-Ming Robman, Luba McCarty, Cathy Chew, Sek Jin Sasaki, Kazuyuki |
author_facet |
Sasaki, Hiroshi Kawakami, Yutaka Ono, Masaji Jonasson, Fridbert Shui, Ying Bo Cheng, Hong-Ming Robman, Luba McCarty, Cathy Chew, Sek Jin Sasaki, Kazuyuki |
author_sort |
Sasaki, Hiroshi |
title |
Localization of cortical cataract in subjects of diverse races and latitude |
title_short |
Localization of cortical cataract in subjects of diverse races and latitude |
title_full |
Localization of cortical cataract in subjects of diverse races and latitude |
title_fullStr |
Localization of cortical cataract in subjects of diverse races and latitude |
title_full_unstemmed |
Localization of cortical cataract in subjects of diverse races and latitude |
title_sort |
localization of cortical cataract in subjects of diverse races and latitude |
publisher |
Association For Research In Vision And Ophthalmology (Arvo) |
publishDate |
2003 |
url |
http://hdl.handle.net/2336/4630 https://doi.org/10.1167/iovs.01-1221 |
geographic |
Reykjavík |
geographic_facet |
Reykjavík |
genre |
Iceland Reykjavík Reykjavík |
genre_facet |
Iceland Reykjavík Reykjavík |
op_relation |
http://www.iovs.org/cgi/content/full/44/10/4210 Invest. Ophthalmol. Vis. Sci. 2003, 44(10):4210-4 0146-0404 14507863 doi:10.1167/iovs.01-1221 OPH12 http://hdl.handle.net/2336/4630 |
op_doi |
https://doi.org/10.1167/iovs.01-1221 |
container_title |
Investigative Opthalmology & Visual Science |
container_volume |
44 |
container_issue |
10 |
container_start_page |
4210 |
_version_ |
1766041908123009024 |