Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria
OBJECTIVE: To find the incidence of juvenile arthritis according to the ILAR and EULAR criteria within defined areas in the Nordic countries, and to study the validity of the ILAR and EULAR criteria from this perspective. METHOD: A longitudinal, prospective, population based study with patients enro...
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2003
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/4586 2023-05-15T16:48:18+02:00 Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria Berntson, Lillemor Andersson Gäre, Boel Fasth, Anders Herlin, Troels Kristinsson, Jon Lahdenne, Pekka Marhaug, Gudmund Nielsen, Susan Pelkonen, Pirkko Rygg, Marite 2003-10-01 YES http://hdl.handle.net/2336/4586 en eng Journal Of Rheumatology Publishing Co http://jrheum.com/subscribers/03/10/2275.html J. Rheumatol. 2003, 30(10):2275-82 0315-162X 14528529 PED12 http://hdl.handle.net/2336/4586 Journal of rheumatology Adolescent Antibodies Antinuclear Age of Onset Arthritis Juvenile Rheumatoid Child Preschool Comparative Study Female Finland/epidemiology Humans Iceland/epidemiology Incidence Infant Male Prospective Studies Research Support Non-U.S. Gov't Scandinavia/epidemiology Article 2003 ftlandspitaliuni 2022-05-29T08:20:53Z OBJECTIVE: To find the incidence of juvenile arthritis according to the ILAR and EULAR criteria within defined areas in the Nordic countries, and to study the validity of the ILAR and EULAR criteria from this perspective. METHOD: A longitudinal, prospective, population based study with patients enrolled according to the ILAR and EULAR criteria. Twenty doctors in Iceland, Norway, Sweden, Denmark, and Finland collected data from the incidence cases within their catchment areas over a period of 1.5 years, beginning July 1, 1997. Clinical and serological data from the first year of the disease were collected. RESULTS: In the whole group of 315 patients, the incidence rate was 15 per 100,000 children/year (95% CI 13-17) according to the ILAR criteria, varying from 7 (1-13) in Iceland, 19 (7-31) and 23 (10-36) from 2 different regions in Norway, and 9 (5-12) and 16 (9-23) from 2 different areas in Denmark, to 15 (12-18) in Sweden and 21/100,000/year (15-26) in the Helsinki region in Finland. An early peak in distribution for age of onset was found in girls but not in boys. The number of antinuclear antibody (ANA) positive children in the whole group, made up of children who had undergone at least one analyzed ANA test, was 123/315 (39%). Girls were ANA positive in 83/197 (42%) and boys in 40/118 (34%). Uveitis developed in 27/315 (8.6%) children during the first 6 months of the disease. CONCLUSION: Incidence rates of juvenile arthritis for areas within the Nordic countries were in accord with previous data. The ILAR criteria present slightly higher incidence rates, with a shorter disease duration for inclusion, compared to the EULAR criteria. Patients in one subgroup in either of the criteria sets do not necessarily belong to the expected subgroup in the other set of criteria; e.g., for juvenile ankylosing spondylitis (EULAR) and enthesitis related arthritis (ILAR). Our epidemiological findings are a reminder to be aware of possible new subgroups in children with juvenile arthritis. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Norway |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Antibodies Antinuclear Age of Onset Arthritis Juvenile Rheumatoid Child Preschool Comparative Study Female Finland/epidemiology Humans Iceland/epidemiology Incidence Infant Male Prospective Studies Research Support Non-U.S. Gov't Scandinavia/epidemiology |
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Adolescent Antibodies Antinuclear Age of Onset Arthritis Juvenile Rheumatoid Child Preschool Comparative Study Female Finland/epidemiology Humans Iceland/epidemiology Incidence Infant Male Prospective Studies Research Support Non-U.S. Gov't Scandinavia/epidemiology Berntson, Lillemor Andersson Gäre, Boel Fasth, Anders Herlin, Troels Kristinsson, Jon Lahdenne, Pekka Marhaug, Gudmund Nielsen, Susan Pelkonen, Pirkko Rygg, Marite Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria |
topic_facet |
Adolescent Antibodies Antinuclear Age of Onset Arthritis Juvenile Rheumatoid Child Preschool Comparative Study Female Finland/epidemiology Humans Iceland/epidemiology Incidence Infant Male Prospective Studies Research Support Non-U.S. Gov't Scandinavia/epidemiology |
description |
OBJECTIVE: To find the incidence of juvenile arthritis according to the ILAR and EULAR criteria within defined areas in the Nordic countries, and to study the validity of the ILAR and EULAR criteria from this perspective. METHOD: A longitudinal, prospective, population based study with patients enrolled according to the ILAR and EULAR criteria. Twenty doctors in Iceland, Norway, Sweden, Denmark, and Finland collected data from the incidence cases within their catchment areas over a period of 1.5 years, beginning July 1, 1997. Clinical and serological data from the first year of the disease were collected. RESULTS: In the whole group of 315 patients, the incidence rate was 15 per 100,000 children/year (95% CI 13-17) according to the ILAR criteria, varying from 7 (1-13) in Iceland, 19 (7-31) and 23 (10-36) from 2 different regions in Norway, and 9 (5-12) and 16 (9-23) from 2 different areas in Denmark, to 15 (12-18) in Sweden and 21/100,000/year (15-26) in the Helsinki region in Finland. An early peak in distribution for age of onset was found in girls but not in boys. The number of antinuclear antibody (ANA) positive children in the whole group, made up of children who had undergone at least one analyzed ANA test, was 123/315 (39%). Girls were ANA positive in 83/197 (42%) and boys in 40/118 (34%). Uveitis developed in 27/315 (8.6%) children during the first 6 months of the disease. CONCLUSION: Incidence rates of juvenile arthritis for areas within the Nordic countries were in accord with previous data. The ILAR criteria present slightly higher incidence rates, with a shorter disease duration for inclusion, compared to the EULAR criteria. Patients in one subgroup in either of the criteria sets do not necessarily belong to the expected subgroup in the other set of criteria; e.g., for juvenile ankylosing spondylitis (EULAR) and enthesitis related arthritis (ILAR). Our epidemiological findings are a reminder to be aware of possible new subgroups in children with juvenile arthritis. |
format |
Article in Journal/Newspaper |
author |
Berntson, Lillemor Andersson Gäre, Boel Fasth, Anders Herlin, Troels Kristinsson, Jon Lahdenne, Pekka Marhaug, Gudmund Nielsen, Susan Pelkonen, Pirkko Rygg, Marite |
author_facet |
Berntson, Lillemor Andersson Gäre, Boel Fasth, Anders Herlin, Troels Kristinsson, Jon Lahdenne, Pekka Marhaug, Gudmund Nielsen, Susan Pelkonen, Pirkko Rygg, Marite |
author_sort |
Berntson, Lillemor |
title |
Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria |
title_short |
Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria |
title_full |
Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria |
title_fullStr |
Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria |
title_full_unstemmed |
Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria |
title_sort |
incidence of juvenile idiopathic arthritis in the nordic countries. a population based study with special reference to the validity of the ilar and eular criteria |
publisher |
Journal Of Rheumatology Publishing Co |
publishDate |
2003 |
url |
http://hdl.handle.net/2336/4586 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://jrheum.com/subscribers/03/10/2275.html J. Rheumatol. 2003, 30(10):2275-82 0315-162X 14528529 PED12 http://hdl.handle.net/2336/4586 Journal of rheumatology |
_version_ |
1766038408446083072 |