Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study.
OBJECTIVE: We estimated the prevalence, incidence and risk factors of left ventricular hypertrophy (LVH) in a prospective cohort study of 26 489 participants. MATERIAL AND METHODS: The LVH was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was define...
Published in: | Journal of Internal Medicine |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Blackwell Publishing
2003
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/4494 https://doi.org/10.1046/j.1365-2796.2003.01111.x |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/4494 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/4494 2023-05-15T16:52:47+02:00 Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. Thrainsdottir, I S Hardarson, Th Thorgeirsson, G Sigvaldason, H Sigfusson, N 2003-04-01 YES http://hdl.handle.net/2336/4494 https://doi.org/10.1046/j.1365-2796.2003.01111.x en eng Blackwell Publishing http://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2796.2003.01111.x http://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2796.2003.01111.x?cookieSet=1 J. Intern. Med. 2003, 253(4):418-24 0954-6820 12653870 doi:10.1046/j.1365-2796.2003.01111.x CAR12 http://hdl.handle.net/2336/4494 Age Factors Aged Cohort Studies Female Humans Hypertrophy Left Ventricular/epidemiology/*mortality Iceland/epidemiology Incidence Male Prospective Studies Risk Factors Sex Distribution Survival Analysis Article 2003 ftlandspitaliuni https://doi.org/10.1046/j.1365-2796.2003.01111.x 2022-05-29T08:20:53Z OBJECTIVE: We estimated the prevalence, incidence and risk factors of left ventricular hypertrophy (LVH) in a prospective cohort study of 26 489 participants. MATERIAL AND METHODS: The LVH was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. The comparison cohort were all other participants in the Reykjavik Study stages I-V. RESULTS: A total of 297 men and 49 women were found to have LVH of 3.2% and 0.5%, respectively. The incidence was 25 per 1000 per year amongst men and six per 1000 per year amongst women. Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure [odds ratio (OR) per mmHg 1.02; 95% confidence interval (CI): 1.01-1.03], age (OR per year 1.04; 95% CI: 1.02-1.05), silent myocardial infarction (MI) (OR 3.18; 95% CI: 1.39-7.27) and ST-T changes (OR 3.06; 95% CI: 2.14-4.38) amongst men and systolic blood pressure and age for women with similar odds ratio. Predictive factors for acquiring LVH were systolic blood pressure [incidence ratio (IR) 1.01; 95% CI: 1.01-1.02] and angina with ECG changes (IR 2.33; 95% CI: 1.08-5.02) amongst men and systolic blood pressure amongst women (IR 1.03; 95% CI: 1.01-1.04). The risk for coronary mortality was significantly increased amongst women with hypertrophy [hazard ratio (HR) 3.07; 95% CI: 1.5-6.31] and their total survival was poorer with increasing time from diagnosis of LVH (HR 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of LVH and its appearance is associated with age and increased blood pressure amongst both genders. Women with LVH have poorer survival than other women and they are at threefold risk of dying of ischaemic heart disease. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Journal of Internal Medicine 253 4 418 424 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Age Factors Aged Cohort Studies Female Humans Hypertrophy Left Ventricular/epidemiology/*mortality Iceland/epidemiology Incidence Male Prospective Studies Risk Factors Sex Distribution Survival Analysis |
spellingShingle |
Age Factors Aged Cohort Studies Female Humans Hypertrophy Left Ventricular/epidemiology/*mortality Iceland/epidemiology Incidence Male Prospective Studies Risk Factors Sex Distribution Survival Analysis Thrainsdottir, I S Hardarson, Th Thorgeirsson, G Sigvaldason, H Sigfusson, N Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. |
topic_facet |
Age Factors Aged Cohort Studies Female Humans Hypertrophy Left Ventricular/epidemiology/*mortality Iceland/epidemiology Incidence Male Prospective Studies Risk Factors Sex Distribution Survival Analysis |
description |
OBJECTIVE: We estimated the prevalence, incidence and risk factors of left ventricular hypertrophy (LVH) in a prospective cohort study of 26 489 participants. MATERIAL AND METHODS: The LVH was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. The comparison cohort were all other participants in the Reykjavik Study stages I-V. RESULTS: A total of 297 men and 49 women were found to have LVH of 3.2% and 0.5%, respectively. The incidence was 25 per 1000 per year amongst men and six per 1000 per year amongst women. Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure [odds ratio (OR) per mmHg 1.02; 95% confidence interval (CI): 1.01-1.03], age (OR per year 1.04; 95% CI: 1.02-1.05), silent myocardial infarction (MI) (OR 3.18; 95% CI: 1.39-7.27) and ST-T changes (OR 3.06; 95% CI: 2.14-4.38) amongst men and systolic blood pressure and age for women with similar odds ratio. Predictive factors for acquiring LVH were systolic blood pressure [incidence ratio (IR) 1.01; 95% CI: 1.01-1.02] and angina with ECG changes (IR 2.33; 95% CI: 1.08-5.02) amongst men and systolic blood pressure amongst women (IR 1.03; 95% CI: 1.01-1.04). The risk for coronary mortality was significantly increased amongst women with hypertrophy [hazard ratio (HR) 3.07; 95% CI: 1.5-6.31] and their total survival was poorer with increasing time from diagnosis of LVH (HR 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of LVH and its appearance is associated with age and increased blood pressure amongst both genders. Women with LVH have poorer survival than other women and they are at threefold risk of dying of ischaemic heart disease. |
format |
Article in Journal/Newspaper |
author |
Thrainsdottir, I S Hardarson, Th Thorgeirsson, G Sigvaldason, H Sigfusson, N |
author_facet |
Thrainsdottir, I S Hardarson, Th Thorgeirsson, G Sigvaldason, H Sigfusson, N |
author_sort |
Thrainsdottir, I S |
title |
Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. |
title_short |
Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. |
title_full |
Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. |
title_fullStr |
Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. |
title_full_unstemmed |
Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study. |
title_sort |
survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: the reykjavik study. |
publisher |
Blackwell Publishing |
publishDate |
2003 |
url |
http://hdl.handle.net/2336/4494 https://doi.org/10.1046/j.1365-2796.2003.01111.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2796.2003.01111.x http://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2796.2003.01111.x?cookieSet=1 J. Intern. Med. 2003, 253(4):418-24 0954-6820 12653870 doi:10.1046/j.1365-2796.2003.01111.x CAR12 http://hdl.handle.net/2336/4494 |
op_doi |
https://doi.org/10.1046/j.1365-2796.2003.01111.x |
container_title |
Journal of Internal Medicine |
container_volume |
253 |
container_issue |
4 |
container_start_page |
418 |
op_container_end_page |
424 |
_version_ |
1766043162255556608 |