Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional c...
Published in: | Nature Genetics |
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Online Access: | http://hdl.handle.net/2336/42077 https://doi.org/10.1038/ng.229 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/42077 2023-05-15T16:50:09+02:00 Sequence variant on 8q24 confers susceptibility to urinary bladder cancer Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K H Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. 2008-12-09 http://hdl.handle.net/2336/42077 https://doi.org/10.1038/ng.229 en eng Nature Pub. Co. http://dx.doi.org/10.1038/ng.229 Nat. Genet. 2008, 40(11):1307-12 1061-4036 18794855 doi:10.1038/ng.229 http://hdl.handle.net/2336/42077 1546-1718 Nature genetics PubMed - in process Urinary Bladder Neoplasms Article 2008 ftlandspitaliuni https://doi.org/10.1038/ng.229 2022-05-29T08:21:13Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)). Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 40 11 1307 1312 |
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PubMed - in process Urinary Bladder Neoplasms |
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PubMed - in process Urinary Bladder Neoplasms Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K H Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
topic_facet |
PubMed - in process Urinary Bladder Neoplasms |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)). |
author2 |
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. |
format |
Article in Journal/Newspaper |
author |
Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K H Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I |
author_facet |
Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K H Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I |
author_sort |
Kiemeney, Lambertus A |
title |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_short |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_full |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_fullStr |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_full_unstemmed |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_sort |
sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
publisher |
Nature Pub. Co. |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/42077 https://doi.org/10.1038/ng.229 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/ng.229 Nat. Genet. 2008, 40(11):1307-12 1061-4036 18794855 doi:10.1038/ng.229 http://hdl.handle.net/2336/42077 1546-1718 Nature genetics |
op_doi |
https://doi.org/10.1038/ng.229 |
container_title |
Nature Genetics |
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40 |
container_issue |
11 |
container_start_page |
1307 |
op_container_end_page |
1312 |
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1766040334186315776 |