Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu
Neðst á síðunni er að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open INTRODUCTION: SHPT is a consequence of decreased concentration of ionized calcium in blood, which may have many causes. The purpose of this study was to assess the prevalence and contributing factors of SHPT...
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Læknafélag Íslands, Læknafélag Reykjavíkur
2005
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/3638 2023-05-15T16:53:01+02:00 Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu Prevalence of secondary hyperparathyroidism (SHPT) and causal factors in adult population in Reykjavík area Snorri Laxdal Karlsson Ólafur Skúli Indriðason Leifur Franzson Gunnar Sigurðsson 2005-02-01 YES http://hdl.handle.net/2336/3638 ice is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://laeknabladid.is Læknablaðið 2005, 91(2):161-9 0023-7213 16155312 http://hdl.handle.net/2336/3638 Læknablaðið Kalsíum Faraldsfræði D-vítamín Fullorðnir LBL12 Fræðigreinar Calcium Dietary Vitamin D Deficiency Parathyroid Hormone Body Composition Hyperparathyroidism Secondary Smoking/adverse effects Iceland/epidemiology Article 2005 ftlandspitaliuni 2022-05-29T08:20:51Z Neðst á síðunni er að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open INTRODUCTION: SHPT is a consequence of decreased concentration of ionized calcium in blood, which may have many causes. The purpose of this study was to assess the prevalence and contributing factors of SHPT in an adult Icelandic population and explore the relationship between PTH and other variables which might explain age related increase in PTH. Such knowledge might be helpful in evaluating the results of PTH measurements. METHODS AND STUDY GROUP: The study group was a random sample of men and women in the Reykjavik area, 30-85 years of age. Serum PTH was measured by ECLIA (Roche Diagnostics), serum 25(OH)D by RIA (DiaSorin), and body composition by DXA. SHPT was defined as PTH >65 ng/l and ionized calcium <1.25 mmol/l. Inadequate vitamin D was defined as serum 25(OH)D 25-45 nmol/l and vitamin D deficiency <25 nmol/l, inadequate calcium intake <800 mg/day (from questionnaire) and reduced kidney function as serum cystatin-C >1.55 ng/l. The relationship between PTH and other variables was assessed by Spearman?s correlation coefficient and linear regression. RESULTS: Of 2,310 individuals invited 1,630 attended (70%), 586 men and 1,023 women. Further 21 were excluded because of primary hyperparathyroidism. Of the total group 6.6% did have SHPT, 7.7% of the women and 4.6% of men (p<0.01 by gender). Underlying causes were identified in 90% of cases, most commonly inadequate vitamin D (73%). Other important causes were obesity, inadequate calcium intake, reduced kidney function and furosemide intake. Many individuals did have more than one possible underlying cause. The concentration of PTH was found in a multivariate linear regression to be associated with age, ionized calcium, 25(OH)D, cystatin-C, smoking, and BMI, especially fat mass. Testosterone did have a weak negative relationship with PTH in men. CONCLUSIONS: Most cases of SHPT could be explained by known causes and far the commonest was inadequate ... Article in Journal/Newspaper Iceland Reykjavík Reykjavík Hirsla - Landspítali University Hospital research archive Reykjavík Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Kalsíum Faraldsfræði D-vítamín Fullorðnir LBL12 Fræðigreinar Calcium Dietary Vitamin D Deficiency Parathyroid Hormone Body Composition Hyperparathyroidism Secondary Smoking/adverse effects Iceland/epidemiology |
spellingShingle |
Kalsíum Faraldsfræði D-vítamín Fullorðnir LBL12 Fræðigreinar Calcium Dietary Vitamin D Deficiency Parathyroid Hormone Body Composition Hyperparathyroidism Secondary Smoking/adverse effects Iceland/epidemiology Snorri Laxdal Karlsson Ólafur Skúli Indriðason Leifur Franzson Gunnar Sigurðsson Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
topic_facet |
Kalsíum Faraldsfræði D-vítamín Fullorðnir LBL12 Fræðigreinar Calcium Dietary Vitamin D Deficiency Parathyroid Hormone Body Composition Hyperparathyroidism Secondary Smoking/adverse effects Iceland/epidemiology |
description |
Neðst á síðunni er að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open INTRODUCTION: SHPT is a consequence of decreased concentration of ionized calcium in blood, which may have many causes. The purpose of this study was to assess the prevalence and contributing factors of SHPT in an adult Icelandic population and explore the relationship between PTH and other variables which might explain age related increase in PTH. Such knowledge might be helpful in evaluating the results of PTH measurements. METHODS AND STUDY GROUP: The study group was a random sample of men and women in the Reykjavik area, 30-85 years of age. Serum PTH was measured by ECLIA (Roche Diagnostics), serum 25(OH)D by RIA (DiaSorin), and body composition by DXA. SHPT was defined as PTH >65 ng/l and ionized calcium <1.25 mmol/l. Inadequate vitamin D was defined as serum 25(OH)D 25-45 nmol/l and vitamin D deficiency <25 nmol/l, inadequate calcium intake <800 mg/day (from questionnaire) and reduced kidney function as serum cystatin-C >1.55 ng/l. The relationship between PTH and other variables was assessed by Spearman?s correlation coefficient and linear regression. RESULTS: Of 2,310 individuals invited 1,630 attended (70%), 586 men and 1,023 women. Further 21 were excluded because of primary hyperparathyroidism. Of the total group 6.6% did have SHPT, 7.7% of the women and 4.6% of men (p<0.01 by gender). Underlying causes were identified in 90% of cases, most commonly inadequate vitamin D (73%). Other important causes were obesity, inadequate calcium intake, reduced kidney function and furosemide intake. Many individuals did have more than one possible underlying cause. The concentration of PTH was found in a multivariate linear regression to be associated with age, ionized calcium, 25(OH)D, cystatin-C, smoking, and BMI, especially fat mass. Testosterone did have a weak negative relationship with PTH in men. CONCLUSIONS: Most cases of SHPT could be explained by known causes and far the commonest was inadequate ... |
format |
Article in Journal/Newspaper |
author |
Snorri Laxdal Karlsson Ólafur Skúli Indriðason Leifur Franzson Gunnar Sigurðsson |
author_facet |
Snorri Laxdal Karlsson Ólafur Skúli Indriðason Leifur Franzson Gunnar Sigurðsson |
author_sort |
Snorri Laxdal Karlsson |
title |
Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
title_short |
Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
title_full |
Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
title_fullStr |
Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
title_full_unstemmed |
Algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
title_sort |
algengi og orsakir afleidds kalkvakaóhófs meðal fullorðinna á höfuðborgarsvæðinu |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/3638 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Reykjavík Smella |
geographic_facet |
Reykjavík Smella |
genre |
Iceland Reykjavík Reykjavík |
genre_facet |
Iceland Reykjavík Reykjavík |
op_relation |
http://laeknabladid.is Læknablaðið 2005, 91(2):161-9 0023-7213 16155312 http://hdl.handle.net/2336/3638 Læknablaðið |
_version_ |
1766043518325751808 |