Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Compelling evidence suggests that childhood leukemia often originates in utero. Birth weight is one of the few pregnancy-related risk factors that has been associated with leuke...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/3511 2023-05-15T16:48:03+02:00 Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Hjalgrim, Henrik Westergaard, Tine Thomassen, Harald Forestier, Erik Gustafsson, Göran Kristinsson, Jon Melbye, Mads Schmiegelow, Kjeld 2004 YES http://hdl.handle.net/2336/3511 https://doi.org/10.1093/jnci/djh287 en eng Oxford University Press http://jnci.oxfordjournals.org/cgi/content/abstract/jnci;96/20/1549 J. Natl. Cancer Inst. 2004, 96(20):1549-56 1460-2105 15494605 doi:10.1093/jnci/djh287 http://hdl.handle.net/2336/3511 Journal of the National Cancer Institute Adolescent Birth Order Birth Weight Case-Control Studies Child Preschool Denmark Gestational Age Iceland Infant Newborn Leukemia Lymphocytic Acute L1 Myelocytic Norway Research Support Non-U.S. Gov't Risk Assessment Risk Factors Sweden Article 2004 ftlandspitaliuni https://doi.org/10.1093/jnci/djh287 2022-05-29T08:20:51Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Compelling evidence suggests that childhood leukemia often originates in utero. Birth weight is one of the few pregnancy-related risk factors that has been associated with leukemia risk, but the association has remained poorly characterized. We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia. METHODS: Overall, 1905 children (aged 0-14 years) with acute lymphoblastic leukemia (ALL) and 299 children with acute myeloid leukemia (AML) diagnosed between January 1, 1984, and December 31, 1999, were identified in the Nordic Society of Paediatric Haematology and Oncology acute leukemia database. Each case patient was matched to five population control subjects (n = 10745) on nationality, age, and sex. All live-born siblings of case patients (n = 3812) and control subjects (n = 17,937) were also identified in population registers. Information on birth weight and gestational age at birth was ascertained from the national Medical Birth Registers. The association between various birth characteristics and leukemia risk was assessed by conditional logistic regression. All statistical tests were two-sided. RESULTS: Risk of ALL overall was statistically significantly associated with birth weight (odds ratio [OR] = 1.26 per 1-kg increase in birth weight, 95% confidence interval [CI] = 1.13 to 1.41). The association was similar for B- and T-lineage ALL and across all diagnostic ages (0-14 years). However, children with ALL did not weigh more at birth than their siblings. Statistically significantly reduced risks of B-precursor ALL were observed with increasing position in the birth order (OR = 0.90 per position increase, 95% CI = 0.84 to 0.96) and increasing gestational age (OR = 0.87 per 2-week increase in gestational age, 95% CI = 0.81 to 0.94). ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Norway JNCI Journal of the National Cancer Institute 96 20 1549 1556 |
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Hirsla - Landspítali University Hospital research archive |
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English |
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Adolescent Birth Order Birth Weight Case-Control Studies Child Preschool Denmark Gestational Age Iceland Infant Newborn Leukemia Lymphocytic Acute L1 Myelocytic Norway Research Support Non-U.S. Gov't Risk Assessment Risk Factors Sweden |
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Adolescent Birth Order Birth Weight Case-Control Studies Child Preschool Denmark Gestational Age Iceland Infant Newborn Leukemia Lymphocytic Acute L1 Myelocytic Norway Research Support Non-U.S. Gov't Risk Assessment Risk Factors Sweden Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Hjalgrim, Henrik Westergaard, Tine Thomassen, Harald Forestier, Erik Gustafsson, Göran Kristinsson, Jon Melbye, Mads Schmiegelow, Kjeld Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland |
topic_facet |
Adolescent Birth Order Birth Weight Case-Control Studies Child Preschool Denmark Gestational Age Iceland Infant Newborn Leukemia Lymphocytic Acute L1 Myelocytic Norway Research Support Non-U.S. Gov't Risk Assessment Risk Factors Sweden |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Compelling evidence suggests that childhood leukemia often originates in utero. Birth weight is one of the few pregnancy-related risk factors that has been associated with leukemia risk, but the association has remained poorly characterized. We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia. METHODS: Overall, 1905 children (aged 0-14 years) with acute lymphoblastic leukemia (ALL) and 299 children with acute myeloid leukemia (AML) diagnosed between January 1, 1984, and December 31, 1999, were identified in the Nordic Society of Paediatric Haematology and Oncology acute leukemia database. Each case patient was matched to five population control subjects (n = 10745) on nationality, age, and sex. All live-born siblings of case patients (n = 3812) and control subjects (n = 17,937) were also identified in population registers. Information on birth weight and gestational age at birth was ascertained from the national Medical Birth Registers. The association between various birth characteristics and leukemia risk was assessed by conditional logistic regression. All statistical tests were two-sided. RESULTS: Risk of ALL overall was statistically significantly associated with birth weight (odds ratio [OR] = 1.26 per 1-kg increase in birth weight, 95% confidence interval [CI] = 1.13 to 1.41). The association was similar for B- and T-lineage ALL and across all diagnostic ages (0-14 years). However, children with ALL did not weigh more at birth than their siblings. Statistically significantly reduced risks of B-precursor ALL were observed with increasing position in the birth order (OR = 0.90 per position increase, 95% CI = 0.84 to 0.96) and increasing gestational age (OR = 0.87 per 2-week increase in gestational age, 95% CI = 0.81 to 0.94). ... |
format |
Article in Journal/Newspaper |
author |
Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Hjalgrim, Henrik Westergaard, Tine Thomassen, Harald Forestier, Erik Gustafsson, Göran Kristinsson, Jon Melbye, Mads Schmiegelow, Kjeld |
author_facet |
Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Hjalgrim, Henrik Westergaard, Tine Thomassen, Harald Forestier, Erik Gustafsson, Göran Kristinsson, Jon Melbye, Mads Schmiegelow, Kjeld |
author_sort |
Hjalgrim, Lisa Lyngsie |
title |
Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland |
title_short |
Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland |
title_full |
Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland |
title_fullStr |
Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland |
title_full_unstemmed |
Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland |
title_sort |
birth weight and risk for childhood leukemia in denmark, sweden, norway, and iceland |
publisher |
Oxford University Press |
publishDate |
2004 |
url |
http://hdl.handle.net/2336/3511 https://doi.org/10.1093/jnci/djh287 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://jnci.oxfordjournals.org/cgi/content/abstract/jnci;96/20/1549 J. Natl. Cancer Inst. 2004, 96(20):1549-56 1460-2105 15494605 doi:10.1093/jnci/djh287 http://hdl.handle.net/2336/3511 Journal of the National Cancer Institute |
op_doi |
https://doi.org/10.1093/jnci/djh287 |
container_title |
JNCI Journal of the National Cancer Institute |
container_volume |
96 |
container_issue |
20 |
container_start_page |
1549 |
op_container_end_page |
1556 |
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1766038141518479360 |