Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive slee...
Published in: | International Journal of Obesity |
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Online Access: | http://hdl.handle.net/2336/346707 https://doi.org/10.1038/ijo.2014.123 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/346707 2023-05-15T16:52:20+02:00 Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. Pak, V M Keenan, B T Jackson, N Grandner, M A Maislin, G Teff, K Schwab, R J Arnardottir, E S Júlíusson, S Benediktsdottir, B Gislason, T Pack, A I Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 2 Biobehavioral Research Center, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA. 2Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 3Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 41 Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 2 Division of Sleep Medicine/Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 5Monell Chemical Senses Center, Philadelphia, PA, USA. 61 University of Iceland, Medical Faculty, Reykjavik, Iceland 2 Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 2015 http://hdl.handle.net/2336/346707 https://doi.org/10.1038/ijo.2014.123 en eng Nature http://dx.doi.org/10.1038/ijo.2014.123 http://www.nature.com/ijo/journal/v39/n3/pdf/ijo2014123a.pdf Int J Obes (Lond) 2015, 39 (3):472-9 1476-5497 25042863 http://hdl.handle.net/2336/346707 International journal of obesity Archived with thanks to International journal of obesity (2005) Landspitali Access - LSH-aðgangur Kæfisvefn Offita Cell Adhesion Molecules Obesity/complications Sleep Apnea Obstructive Article 2015 ftlandspitaliuni https://doi.org/10.1038/ijo.2014.123 2022-05-29T08:22:02Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear. Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes. The mean body mass index (BMI) was 32.4±5.1 kg m(-)(2); subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79% were male. There were 177 full PAP users (⩾4 h per night and ⩾20 of last 28 nights), 44 partial (<4 h per night or <20 nights) and 88 nonusers. ICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, nonusers had increased ICAM-1 compared with decreased levels in full users. All groups had increased VCAM-1, but nonusers had a significantly larger increase than full users. Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease. Eimskip Fund of the University of Iceland, Landspitali University Hospital Research Fund. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive International Journal of Obesity 39 3 472 479 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Kæfisvefn Offita Cell Adhesion Molecules Obesity/complications Sleep Apnea Obstructive |
spellingShingle |
Kæfisvefn Offita Cell Adhesion Molecules Obesity/complications Sleep Apnea Obstructive Pak, V M Keenan, B T Jackson, N Grandner, M A Maislin, G Teff, K Schwab, R J Arnardottir, E S Júlíusson, S Benediktsdottir, B Gislason, T Pack, A I Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
topic_facet |
Kæfisvefn Offita Cell Adhesion Molecules Obesity/complications Sleep Apnea Obstructive |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear. Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes. The mean body mass index (BMI) was 32.4±5.1 kg m(-)(2); subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79% were male. There were 177 full PAP users (⩾4 h per night and ⩾20 of last 28 nights), 44 partial (<4 h per night or <20 nights) and 88 nonusers. ICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, nonusers had increased ICAM-1 compared with decreased levels in full users. All groups had increased VCAM-1, but nonusers had a significantly larger increase than full users. Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease. Eimskip Fund of the University of Iceland, Landspitali University Hospital Research Fund. |
author2 |
Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 2 Biobehavioral Research Center, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA. 2Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 3Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 41 Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 2 Division of Sleep Medicine/Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 5Monell Chemical Senses Center, Philadelphia, PA, USA. 61 University of Iceland, Medical Faculty, Reykjavik, Iceland 2 Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Pak, V M Keenan, B T Jackson, N Grandner, M A Maislin, G Teff, K Schwab, R J Arnardottir, E S Júlíusson, S Benediktsdottir, B Gislason, T Pack, A I |
author_facet |
Pak, V M Keenan, B T Jackson, N Grandner, M A Maislin, G Teff, K Schwab, R J Arnardottir, E S Júlíusson, S Benediktsdottir, B Gislason, T Pack, A I |
author_sort |
Pak, V M |
title |
Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
title_short |
Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
title_full |
Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
title_fullStr |
Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
title_full_unstemmed |
Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
title_sort |
adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. |
publisher |
Nature |
publishDate |
2015 |
url |
http://hdl.handle.net/2336/346707 https://doi.org/10.1038/ijo.2014.123 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/ijo.2014.123 http://www.nature.com/ijo/journal/v39/n3/pdf/ijo2014123a.pdf Int J Obes (Lond) 2015, 39 (3):472-9 1476-5497 25042863 http://hdl.handle.net/2336/346707 International journal of obesity |
op_rights |
Archived with thanks to International journal of obesity (2005) Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1038/ijo.2014.123 |
container_title |
International Journal of Obesity |
container_volume |
39 |
container_issue |
3 |
container_start_page |
472 |
op_container_end_page |
479 |
_version_ |
1766042505106685952 |