Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: The aim of the study was to assess the relationship between size at birth and obesity as well as truncal fat, and its contribution to cardiovascular risk in a high birth weight p...
Published in: | European Journal of Clinical Nutrition |
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Language: | English |
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Nature Publishing Group
2004
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Online Access: | http://hdl.handle.net/2336/3454 https://doi.org/10.1038/sj.ejcn.1601881 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/3454 2023-05-15T16:50:01+02:00 Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. Gunnarsdottir, I Birgisdottir, B E Benediktsson, R Gudnason, V Thorsdottir, I 2004 YES http://hdl.handle.net/2336/3454 https://doi.org/10.1038/sj.ejcn.1601881 en eng Nature Publishing Group http://dx.doi.org/10.1038/sj.ejcn.1601881 Eur J Clin Nutr 2004, 58(5):812-8 0954-3007 15116085 doi:10.1038/sj.ejcn.1601881 http://hdl.handle.net/2336/3454 European journal of clinical nutrition Abdomen Adipose Tissue Adult Aged Birth Weight Body Constitution Body Mass Index Body Weight Cohort Studies Coronary Disease Female Hypertension/epidemiology/*etiology Iceland/epidemiology Infant Newborn Male Middle Aged Obesity Research Support Non-U.S. Gov't Retrospective Studies Skinfold Thickness Article 2004 ftlandspitaliuni https://doi.org/10.1038/sj.ejcn.1601881 2022-05-29T08:20:51Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: The aim of the study was to assess the relationship between size at birth and obesity as well as truncal fat, and its contribution to cardiovascular risk in a high birth weight population. DESIGN: Cohort-study with retrospectively collected data on size at birth. SETTING: Reykjavik, Iceland. SUBJECTS: A total of 1874 men and 1833 women born in Reykjavik during 1914-1935. MAIN OUTCOME MEASURES: Size at birth. Adult weight, height and skinfold thickness measurements, systolic and diastolic blood pressure, fatal and nonfatal coronary heart disease (CHD). RESULTS: Birth weight was positively related to adult body mass index (BMI) in both genders (B=0.35+/-0.14 kg/m(2), adj. R(2)=0.015, P=0.012 and B=0.34+/-0.17 kg/m(2), adj. R(2)=0.055, P=0.043 in men and women, respectively). However, high birth weight was not a risk factor for adult obesity (BMI>/=30 kg/m(2)). In the highest birth weight quartile, the odds ratio (95% CI) for being above the 90th percentile of truncal fat was 0.7 (0.6-1.0, P=0.021) for men and 0.4 (0.3-0.8, P=0.002) for women, compared with the lowest birth weight quartile. Truncal fat and BMI were positively related to blood pressure in both genders (P<0.05), but not to CHD. The regression coefficient for the inverse association between birth weight and blood pressure hardly changed when adding truncal fat to the model. CONCLUSION: In this high birth weight population, high birth weight was related to higher BMI in adulthood without being a risk factor for adult obesity. The inverse association between birth weight and truncal fat in adulthood suggests a role for foetal development in determining adult fat distribution. The inverse relationship of birth weight to blood pressure seems not to be mediated through the same pathway as to truncal fat. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive European Journal of Clinical Nutrition 58 5 812 818 |
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Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Abdomen Adipose Tissue Adult Aged Birth Weight Body Constitution Body Mass Index Body Weight Cohort Studies Coronary Disease Female Hypertension/epidemiology/*etiology Iceland/epidemiology Infant Newborn Male Middle Aged Obesity Research Support Non-U.S. Gov't Retrospective Studies Skinfold Thickness |
spellingShingle |
Abdomen Adipose Tissue Adult Aged Birth Weight Body Constitution Body Mass Index Body Weight Cohort Studies Coronary Disease Female Hypertension/epidemiology/*etiology Iceland/epidemiology Infant Newborn Male Middle Aged Obesity Research Support Non-U.S. Gov't Retrospective Studies Skinfold Thickness Gunnarsdottir, I Birgisdottir, B E Benediktsson, R Gudnason, V Thorsdottir, I Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
topic_facet |
Abdomen Adipose Tissue Adult Aged Birth Weight Body Constitution Body Mass Index Body Weight Cohort Studies Coronary Disease Female Hypertension/epidemiology/*etiology Iceland/epidemiology Infant Newborn Male Middle Aged Obesity Research Support Non-U.S. Gov't Retrospective Studies Skinfold Thickness |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: The aim of the study was to assess the relationship between size at birth and obesity as well as truncal fat, and its contribution to cardiovascular risk in a high birth weight population. DESIGN: Cohort-study with retrospectively collected data on size at birth. SETTING: Reykjavik, Iceland. SUBJECTS: A total of 1874 men and 1833 women born in Reykjavik during 1914-1935. MAIN OUTCOME MEASURES: Size at birth. Adult weight, height and skinfold thickness measurements, systolic and diastolic blood pressure, fatal and nonfatal coronary heart disease (CHD). RESULTS: Birth weight was positively related to adult body mass index (BMI) in both genders (B=0.35+/-0.14 kg/m(2), adj. R(2)=0.015, P=0.012 and B=0.34+/-0.17 kg/m(2), adj. R(2)=0.055, P=0.043 in men and women, respectively). However, high birth weight was not a risk factor for adult obesity (BMI>/=30 kg/m(2)). In the highest birth weight quartile, the odds ratio (95% CI) for being above the 90th percentile of truncal fat was 0.7 (0.6-1.0, P=0.021) for men and 0.4 (0.3-0.8, P=0.002) for women, compared with the lowest birth weight quartile. Truncal fat and BMI were positively related to blood pressure in both genders (P<0.05), but not to CHD. The regression coefficient for the inverse association between birth weight and blood pressure hardly changed when adding truncal fat to the model. CONCLUSION: In this high birth weight population, high birth weight was related to higher BMI in adulthood without being a risk factor for adult obesity. The inverse association between birth weight and truncal fat in adulthood suggests a role for foetal development in determining adult fat distribution. The inverse relationship of birth weight to blood pressure seems not to be mediated through the same pathway as to truncal fat. |
format |
Article in Journal/Newspaper |
author |
Gunnarsdottir, I Birgisdottir, B E Benediktsson, R Gudnason, V Thorsdottir, I |
author_facet |
Gunnarsdottir, I Birgisdottir, B E Benediktsson, R Gudnason, V Thorsdottir, I |
author_sort |
Gunnarsdottir, I |
title |
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
title_short |
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
title_full |
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
title_fullStr |
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
title_full_unstemmed |
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
title_sort |
association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population. |
publisher |
Nature Publishing Group |
publishDate |
2004 |
url |
http://hdl.handle.net/2336/3454 https://doi.org/10.1038/sj.ejcn.1601881 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/sj.ejcn.1601881 Eur J Clin Nutr 2004, 58(5):812-8 0954-3007 15116085 doi:10.1038/sj.ejcn.1601881 http://hdl.handle.net/2336/3454 European journal of clinical nutrition |
op_doi |
https://doi.org/10.1038/sj.ejcn.1601881 |
container_title |
European Journal of Clinical Nutrition |
container_volume |
58 |
container_issue |
5 |
container_start_page |
812 |
op_container_end_page |
818 |
_version_ |
1766040194376531968 |