Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearl...
Published in: | Scandinavian Journal of Rheumatology |
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Online Access: | http://hdl.handle.net/2336/34292 https://doi.org/10.1080/030097400750002094 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/34292 2023-05-15T16:50:09+02:00 Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study Jonsson, T Thorsteinsson, J Valdimarsson, H Department of Immunology, National University Hospital, Landspítalinn Reykjavík, Iceland. 2008-08-05 http://hdl.handle.net/2336/34292 https://doi.org/10.1080/030097400750002094 en eng Taylor & Francis http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=4347879&site=ehost-live Scand. J. Rheumatol. 2000, 29(3):190-1 0300-9742 10898074 doi:10.1080/030097400750002094 http://hdl.handle.net/2336/34292 Scandinavian journal of rheumatology Adult Aged Arthritis Rheumatoid Enzyme-Linked Immunosorbent Assay Female Humans Iceland Immunoglobulin A Immunoglobulin Isotypes Immunoglobulin M Male Middle Aged Prevalence Prospective Studies Rheumatoid Factor Article 2008 ftlandspitaliuni https://doi.org/10.1080/030097400750002094 2022-05-29T08:21:12Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearly 14,000 randomly selected individuals, were screened for elevation of RF. In 1987, 173 RF positive and 156 matched RF negative participants were evaluated clinically. RESULTS: Participants with elevation of only one RF isotype, most commonly IgM, did not have significantly higher prevalence of RA than the RF negative controls. Of the 17 RF positive individuals who were diagnosed with RA, 14 (82%) had a combined elevation of IgM and IgA RF. CONCLUSION: In contrast to a combined elevation of IgM and IgA RF, elevation of only one RF isotype may not be a significant risk factor for the development of RA. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Rheumatology 29 3 190 191 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adult Aged Arthritis Rheumatoid Enzyme-Linked Immunosorbent Assay Female Humans Iceland Immunoglobulin A Immunoglobulin Isotypes Immunoglobulin M Male Middle Aged Prevalence Prospective Studies Rheumatoid Factor |
spellingShingle |
Adult Aged Arthritis Rheumatoid Enzyme-Linked Immunosorbent Assay Female Humans Iceland Immunoglobulin A Immunoglobulin Isotypes Immunoglobulin M Male Middle Aged Prevalence Prospective Studies Rheumatoid Factor Jonsson, T Thorsteinsson, J Valdimarsson, H Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
topic_facet |
Adult Aged Arthritis Rheumatoid Enzyme-Linked Immunosorbent Assay Female Humans Iceland Immunoglobulin A Immunoglobulin Isotypes Immunoglobulin M Male Middle Aged Prevalence Prospective Studies Rheumatoid Factor |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearly 14,000 randomly selected individuals, were screened for elevation of RF. In 1987, 173 RF positive and 156 matched RF negative participants were evaluated clinically. RESULTS: Participants with elevation of only one RF isotype, most commonly IgM, did not have significantly higher prevalence of RA than the RF negative controls. Of the 17 RF positive individuals who were diagnosed with RA, 14 (82%) had a combined elevation of IgM and IgA RF. CONCLUSION: In contrast to a combined elevation of IgM and IgA RF, elevation of only one RF isotype may not be a significant risk factor for the development of RA. |
author2 |
Department of Immunology, National University Hospital, Landspítalinn Reykjavík, Iceland. |
format |
Article in Journal/Newspaper |
author |
Jonsson, T Thorsteinsson, J Valdimarsson, H |
author_facet |
Jonsson, T Thorsteinsson, J Valdimarsson, H |
author_sort |
Jonsson, T |
title |
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
title_short |
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
title_full |
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
title_fullStr |
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
title_full_unstemmed |
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
title_sort |
elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study |
publisher |
Taylor & Francis |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/34292 https://doi.org/10.1080/030097400750002094 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=4347879&site=ehost-live Scand. J. Rheumatol. 2000, 29(3):190-1 0300-9742 10898074 doi:10.1080/030097400750002094 http://hdl.handle.net/2336/34292 Scandinavian journal of rheumatology |
op_doi |
https://doi.org/10.1080/030097400750002094 |
container_title |
Scandinavian Journal of Rheumatology |
container_volume |
29 |
container_issue |
3 |
container_start_page |
190 |
op_container_end_page |
191 |
_version_ |
1766040333848674304 |