Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearl...

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Bibliographic Details
Published in:Scandinavian Journal of Rheumatology
Main Authors: Jonsson, T, Thorsteinsson, J, Valdimarsson, H
Other Authors: Department of Immunology, National University Hospital, Landspítalinn Reykjavík, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Taylor & Francis 2008
Subjects:
Adult
Aged
Arthritis
Rheumatoid
Enzyme-Linked Immunosorbent Assay
Female
Humans
Iceland
Immunoglobulin A
Immunoglobulin Isotypes
Immunoglobulin M
Male
Middle Aged
Prevalence
Prospective Studies
Rheumatoid Factor
Online Access:http://hdl.handle.net/2336/34292
https://doi.org/10.1080/030097400750002094
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearly 14,000 randomly selected individuals, were screened for elevation of RF. In 1987, 173 RF positive and 156 matched RF negative participants were evaluated clinically. RESULTS: Participants with elevation of only one RF isotype, most commonly IgM, did not have significantly higher prevalence of RA than the RF negative controls. Of the 17 RF positive individuals who were diagnosed with RA, 14 (82%) had a combined elevation of IgM and IgA RF. CONCLUSION: In contrast to a combined elevation of IgM and IgA RF, elevation of only one RF isotype may not be a significant risk factor for the development of RA.

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