Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field To investigate the association between age-related macular degeneration (AMD) and mortality in older persons. Population-based prospective cohort study. Participants 67 to 96 years o...
Published in: | Ophthalmology |
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Main Authors: | , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Elsevier
2015
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Online Access: | http://hdl.handle.net/2336/338545 https://doi.org/10.1016/j.ophtha.2014.08.006 |
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Hirsla - Landspítali University Hospital research archive |
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English |
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Sjónhimna Hrörnunarsjúkdómar Aldraðir Macular Degeneration/mortality* Aged Cause of Death Cardiovascular Diseases Age Factors 80 and over Cohort Studies Disease Susceptibility Female Follow-Up Studies Gene-Environment Interaction* Humans Iceland/epidemiology Incidence Male Proportional Hazards Models Prospective Studies Risk Factors |
spellingShingle |
Sjónhimna Hrörnunarsjúkdómar Aldraðir Macular Degeneration/mortality* Aged Cause of Death Cardiovascular Diseases Age Factors 80 and over Cohort Studies Disease Susceptibility Female Follow-Up Studies Gene-Environment Interaction* Humans Iceland/epidemiology Incidence Male Proportional Hazards Models Prospective Studies Risk Factors Fisher, Diana E Jonasson, Fridbert Eiriksdottir, Gudny Sigurdsson, Sigurdur Klein, Ronald Launer, Lenore J Gudnason, Vilmundur Cotch, Mary Frances Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. |
topic_facet |
Sjónhimna Hrörnunarsjúkdómar Aldraðir Macular Degeneration/mortality* Aged Cause of Death Cardiovascular Diseases Age Factors 80 and over Cohort Studies Disease Susceptibility Female Follow-Up Studies Gene-Environment Interaction* Humans Iceland/epidemiology Incidence Male Proportional Hazards Models Prospective Studies Risk Factors |
description |
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field To investigate the association between age-related macular degeneration (AMD) and mortality in older persons. Population-based prospective cohort study. Participants 67 to 96 years of age (43.1% male) enrolled between 2002 and 2006 in the Age, Gene/Environment Susceptibility-Reykjavik Study. Retinal photographs of the macula were acquired digitally and evaluated for the presence of AMID lesions using the Wisconsin Age-Related Maculopathy grading scheme. Mortality was assessed prospectively through 2013 with cause of death available through 2009. The association between AMD and death, resulting from any cause and specifically cardiovascular disease (CVD), was examined using Cox proportional hazards regression with age as the time scale, adjusted for significant risk factors and comorbid conditions. To address a violation in the proportional hazards assumption, analyses were stratified into 2 groups based on the mean age at death (83 years). Mortality resulting from all causes and CVD. Among 4910 participants, after a median follow-up of 8.6 years, 1742 died (35.5%), of whom 614 (35.2%) had signs of AMD at baseline. Cardiovascular disease was the cause of death for 357 people who died before the end of 2009, of whom 144 (40%) had AMD (101 with early disease and 43 with late disease). After considering covariates, including comorbid conditions, having early AMD at any age or having late AMD in individuals younger than 83 years (n = 4179) were not associated with all-cause or CVD mortality. In individuals 83 years of age and older (n = 731), late AMD was associated significantly with increased risk of all-cause mortality (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.20-2.57) and CVD-related mortality (HR, 2.37; 95% CI, 1.41-3.98). In addition to having AMD, older individuals who died were more likely to be male and to have low body mass index, impaired cognition, and ... |
author2 |
1Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: diana.fisher@nih.gov. 2Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3Icelandic Heart Association, Kopavogur, Iceland. 4Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin. 5Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute of Aging, National Institutes of Health, Bethesda, Maryland. 6Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland. 7Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. |
format |
Article in Journal/Newspaper |
author |
Fisher, Diana E Jonasson, Fridbert Eiriksdottir, Gudny Sigurdsson, Sigurdur Klein, Ronald Launer, Lenore J Gudnason, Vilmundur Cotch, Mary Frances |
author_facet |
Fisher, Diana E Jonasson, Fridbert Eiriksdottir, Gudny Sigurdsson, Sigurdur Klein, Ronald Launer, Lenore J Gudnason, Vilmundur Cotch, Mary Frances |
author_sort |
Fisher, Diana E |
title |
Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. |
title_short |
Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. |
title_full |
Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. |
title_fullStr |
Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. |
title_full_unstemmed |
Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. |
title_sort |
age-related macular degeneration and mortality in community-dwelling elders: the age, gene/environment susceptibility reykjavik study. |
publisher |
Elsevier |
publishDate |
2015 |
url |
http://hdl.handle.net/2336/338545 https://doi.org/10.1016/j.ophtha.2014.08.006 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/j.ophtha.2014.08.006 Ophthalmology 2015,122(2):382-90 1549-4713 25264026 doi:10.1016/j.ophtha.2014.08.006 http://hdl.handle.net/2336/338545 Ophthalmology |
op_rights |
Archived with thanks to Ophthalmology Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1016/j.ophtha.2014.08.006 |
container_title |
Ophthalmology |
container_volume |
122 |
container_issue |
2 |
container_start_page |
382 |
op_container_end_page |
390 |
_version_ |
1766043528286175232 |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/338545 2023-05-15T16:53:01+02:00 Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study. Fisher, Diana E Jonasson, Fridbert Eiriksdottir, Gudny Sigurdsson, Sigurdur Klein, Ronald Launer, Lenore J Gudnason, Vilmundur Cotch, Mary Frances 1Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: diana.fisher@nih.gov. 2Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3Icelandic Heart Association, Kopavogur, Iceland. 4Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin. 5Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute of Aging, National Institutes of Health, Bethesda, Maryland. 6Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland. 7Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. 2015 http://hdl.handle.net/2336/338545 https://doi.org/10.1016/j.ophtha.2014.08.006 ENG en eng Elsevier http://dx.doi.org/10.1016/j.ophtha.2014.08.006 Ophthalmology 2015,122(2):382-90 1549-4713 25264026 doi:10.1016/j.ophtha.2014.08.006 http://hdl.handle.net/2336/338545 Ophthalmology Archived with thanks to Ophthalmology Landspitali Access - LSH-aðgangur Sjónhimna Hrörnunarsjúkdómar Aldraðir Macular Degeneration/mortality* Aged Cause of Death Cardiovascular Diseases Age Factors 80 and over Cohort Studies Disease Susceptibility Female Follow-Up Studies Gene-Environment Interaction* Humans Iceland/epidemiology Incidence Male Proportional Hazards Models Prospective Studies Risk Factors Article 2015 ftlandspitaliuni https://doi.org/10.1016/j.ophtha.2014.08.006 2022-05-29T08:22:02Z To access publisher's full text version of this article, please click on the hyperlink in Additional Links field To investigate the association between age-related macular degeneration (AMD) and mortality in older persons. Population-based prospective cohort study. Participants 67 to 96 years of age (43.1% male) enrolled between 2002 and 2006 in the Age, Gene/Environment Susceptibility-Reykjavik Study. Retinal photographs of the macula were acquired digitally and evaluated for the presence of AMID lesions using the Wisconsin Age-Related Maculopathy grading scheme. Mortality was assessed prospectively through 2013 with cause of death available through 2009. The association between AMD and death, resulting from any cause and specifically cardiovascular disease (CVD), was examined using Cox proportional hazards regression with age as the time scale, adjusted for significant risk factors and comorbid conditions. To address a violation in the proportional hazards assumption, analyses were stratified into 2 groups based on the mean age at death (83 years). Mortality resulting from all causes and CVD. Among 4910 participants, after a median follow-up of 8.6 years, 1742 died (35.5%), of whom 614 (35.2%) had signs of AMD at baseline. Cardiovascular disease was the cause of death for 357 people who died before the end of 2009, of whom 144 (40%) had AMD (101 with early disease and 43 with late disease). After considering covariates, including comorbid conditions, having early AMD at any age or having late AMD in individuals younger than 83 years (n = 4179) were not associated with all-cause or CVD mortality. In individuals 83 years of age and older (n = 731), late AMD was associated significantly with increased risk of all-cause mortality (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.20-2.57) and CVD-related mortality (HR, 2.37; 95% CI, 1.41-3.98). In addition to having AMD, older individuals who died were more likely to be male and to have low body mass index, impaired cognition, and ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Ophthalmology 122 2 382 390 |