A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To describe a large kinship with inherited hip osteoarthritis (OA) and its associated susceptibility locus. METHODS: Four generations of a kinship with familial hip OA were ident...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/33393 2023-05-15T16:51:49+02:00 A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. Ingvarsson, T Stefánsson, SE Gulcher, JR Jónsson, HH Jónsson, H Frigge, ML Pálsdóttir, E Olafsdóttir, G Jónsdóttir, T Walters, GB Lohmander, LS Stefánsson, K University Hospital, Akureyri, Iceland. thi@fsa.is 2008-07-28 http://hdl.handle.net/2336/33393 https://doi.org/10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S en eng Wiley-Liss, Inc. http://dx.doi.org/10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S Arthritis Rheum. 2001, 44(11):2548-55 0004-3591 11710711 doi:10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S http://hdl.handle.net/2336/33393 Arthritis and rheumatism Adolescent Adult Arthroplasty Replacement Hip Chromosomes Human Pair 16 Female Femur Head Genetic Predisposition to Disease Humans Iceland Lod Score Male Middle Aged Osteoarthritis Knee Pedigree Phenotype Article 2008 ftlandspitaliuni https://doi.org/10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S 2022-05-29T08:21:12Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To describe a large kinship with inherited hip osteoarthritis (OA) and its associated susceptibility locus. METHODS: Four generations of a kinship with familial hip OA were identified and characterized by family history and by clinical, radiographic, and histopathologic examination. In the genome-wide search for a susceptibility locus, OA cases were defined as those who had undergone total hip replacement associated with a clinical and radiographic diagnosis of hip OA. A genome-wide scan was performed using a framework set of microsatellite markers with an average spacing of 10 cM. RESULTS: The hip OA of this family was indistinguishable from that of idiopathic, nonfamilial hip OA. There was no apparent evidence of spondyloepiphyseal dysplasia or other dysplasias usually associated with mutations in collagen genes. The genome-wide scan revealed a locus on chromosome 16p between 28 cM and 47 cM from the telomere, and this locus met the criteria for suggestive linkage (multipoint allele-sharing logarithm of odds [LOD] score 2.58, P = 1.6 x 10(-4)). Two additional regions with LOD scores of >1.5 were obtained. CONCLUSION: We have identified and described the largest kinship with familial hip OA reported to date. Evidence for linkage in this family suggests that a gene for susceptibility to hip OA exists on chromosome 16p. This represents an independent identification of a susceptibility locus previously reported for hip OA in this geographic region. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Arthroplasty Replacement Hip Chromosomes Human Pair 16 Female Femur Head Genetic Predisposition to Disease Humans Iceland Lod Score Male Middle Aged Osteoarthritis Knee Pedigree Phenotype |
spellingShingle |
Adolescent Adult Arthroplasty Replacement Hip Chromosomes Human Pair 16 Female Femur Head Genetic Predisposition to Disease Humans Iceland Lod Score Male Middle Aged Osteoarthritis Knee Pedigree Phenotype Ingvarsson, T Stefánsson, SE Gulcher, JR Jónsson, HH Jónsson, H Frigge, ML Pálsdóttir, E Olafsdóttir, G Jónsdóttir, T Walters, GB Lohmander, LS Stefánsson, K A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
topic_facet |
Adolescent Adult Arthroplasty Replacement Hip Chromosomes Human Pair 16 Female Femur Head Genetic Predisposition to Disease Humans Iceland Lod Score Male Middle Aged Osteoarthritis Knee Pedigree Phenotype |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To describe a large kinship with inherited hip osteoarthritis (OA) and its associated susceptibility locus. METHODS: Four generations of a kinship with familial hip OA were identified and characterized by family history and by clinical, radiographic, and histopathologic examination. In the genome-wide search for a susceptibility locus, OA cases were defined as those who had undergone total hip replacement associated with a clinical and radiographic diagnosis of hip OA. A genome-wide scan was performed using a framework set of microsatellite markers with an average spacing of 10 cM. RESULTS: The hip OA of this family was indistinguishable from that of idiopathic, nonfamilial hip OA. There was no apparent evidence of spondyloepiphyseal dysplasia or other dysplasias usually associated with mutations in collagen genes. The genome-wide scan revealed a locus on chromosome 16p between 28 cM and 47 cM from the telomere, and this locus met the criteria for suggestive linkage (multipoint allele-sharing logarithm of odds [LOD] score 2.58, P = 1.6 x 10(-4)). Two additional regions with LOD scores of >1.5 were obtained. CONCLUSION: We have identified and described the largest kinship with familial hip OA reported to date. Evidence for linkage in this family suggests that a gene for susceptibility to hip OA exists on chromosome 16p. This represents an independent identification of a susceptibility locus previously reported for hip OA in this geographic region. |
author2 |
University Hospital, Akureyri, Iceland. thi@fsa.is |
format |
Article in Journal/Newspaper |
author |
Ingvarsson, T Stefánsson, SE Gulcher, JR Jónsson, HH Jónsson, H Frigge, ML Pálsdóttir, E Olafsdóttir, G Jónsdóttir, T Walters, GB Lohmander, LS Stefánsson, K |
author_facet |
Ingvarsson, T Stefánsson, SE Gulcher, JR Jónsson, HH Jónsson, H Frigge, ML Pálsdóttir, E Olafsdóttir, G Jónsdóttir, T Walters, GB Lohmander, LS Stefánsson, K |
author_sort |
Ingvarsson, T |
title |
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
title_short |
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
title_full |
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
title_fullStr |
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
title_full_unstemmed |
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
title_sort |
large icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. |
publisher |
Wiley-Liss, Inc. |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/33393 https://doi.org/10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S Arthritis Rheum. 2001, 44(11):2548-55 0004-3591 11710711 doi:10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S http://hdl.handle.net/2336/33393 Arthritis and rheumatism |
op_doi |
https://doi.org/10.1002/1529-0131(200111)44:11<2548::AID-ART435>3.0.CO;2-S |
_version_ |
1766041913488572416 |