Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page The first penicillin-non-susceptible pneumococci (PNSP) were identified in Iceland in 1988. A rapid increase followed, associated with expansion of a single multiresistant clone, Spain(6B)-2...
Published in: | Journal of Antimicrobial Chemotherapy |
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2014
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Online Access: | http://hdl.handle.net/2336/326091 https://doi.org/10.1093/jac/dkt470 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/326091 2023-05-15T16:47:14+02:00 Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. Hjálmarsdóttir, M Á Kristinsson, K G a Department of Clinical Microbiology, Landspitali University Hospital, Baronsstig, 101 Reykjavik, Iceland b University of Iceland, Stapi v/Hringbraut, 101 Reykjavik, Iceland 2014 http://hdl.handle.net/2336/326091 https://doi.org/10.1093/jac/dkt470 en eng Oxford University Press http://dx.doi.org/10.1093/jac/dkt470 J. Antimicrob. Chemother. 2014, 69 (4):940-6 1460-2091 24311742 doi:10.1093/jac/dkt470 http://hdl.handle.net/2336/326091 The Journal of antimicrobial chemotherapy Archived with thanks to The Journal of antimicrobial chemotherapy Closed - Lokað Lungnabólga Lyfjagjöf Streptococcus pneumoniae/drug effects* Erythromycin Tetracycline Drug Resistance Bacterial Adolescent Adult Aged 80 and over Child Preschool Electrophoresis Gel Pulsed-Field Female Genotype Humans Iceland/epidemiology Infant Newborn Male Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Penicillin Resistance* Pneumococcal Infections/epidemiology* Pneumococcal Infections/microbiology* Prevalence Serotyping Streptococcus pneumoniae/isolation & purification Young Adult Article 2014 ftlandspitaliuni https://doi.org/10.1093/jac/dkt470 2022-05-29T08:22:00Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page The first penicillin-non-susceptible pneumococci (PNSP) were identified in Iceland in 1988. A rapid increase followed, associated with expansion of a single multiresistant clone, Spain(6B)-2, peaking at 19.8% in 1993. After interventions led to reduced antimicrobial use in children, the prevalence of PNSP decreased until 1995. The aim of this study was to follow the evolution of PNSP from 1995 to 2010, the period preceding the introduction of conjugated pneumococcal vaccines into the vaccination programme. The laboratory at the Landspitali University Hospital serves ∼ 85% of the Icelandic population. All pneumococci isolated from 1995 to 2010 (n = 13,937) were stored (-80 °C). Oxacillin-resistant isolates were serotyped and penicillin MICs were determined. Selected strains were genotyped by PFGE and multilocus sequence typing. In 1995, the rate of PNSP was 24.2%, declining to 13.6% in 2001, and then increasing to 38.6% in 2010. Similar changes were observed for resistance to erythromycin and tetracycline. In 1995, 60.7% of PNSP were serotype 6B, mainly the Spain(6B)-2 clone, declining to 5.7% in 2010. PNSP of serotype 19F rapidly increased after 2004 to comprise 85.8% of all serogrouped PNSP in 2010, with most isolates belonging to a single multiresistant PFGE clone identified as sequence type (ST) 271 and ST1968, representing single- and double-locus variants of the international clone Taiwan(19F)-14, respectively. PNSP were most common among young children, from the nasopharynx, middle ear and lower respiratory tract. The epidemiology of PNSP was dominated by two multiresistant clones. The second expanded rapidly when the first one was disappearing, causing higher antibiotic resistance rates among pneumococci than seen before in Iceland. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Journal of Antimicrobial Chemotherapy 69 4 940 946 |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Lungnabólga Lyfjagjöf Streptococcus pneumoniae/drug effects* Erythromycin Tetracycline Drug Resistance Bacterial Adolescent Adult Aged 80 and over Child Preschool Electrophoresis Gel Pulsed-Field Female Genotype Humans Iceland/epidemiology Infant Newborn Male Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Penicillin Resistance* Pneumococcal Infections/epidemiology* Pneumococcal Infections/microbiology* Prevalence Serotyping Streptococcus pneumoniae/isolation & purification Young Adult |
spellingShingle |
Lungnabólga Lyfjagjöf Streptococcus pneumoniae/drug effects* Erythromycin Tetracycline Drug Resistance Bacterial Adolescent Adult Aged 80 and over Child Preschool Electrophoresis Gel Pulsed-Field Female Genotype Humans Iceland/epidemiology Infant Newborn Male Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Penicillin Resistance* Pneumococcal Infections/epidemiology* Pneumococcal Infections/microbiology* Prevalence Serotyping Streptococcus pneumoniae/isolation & purification Young Adult Hjálmarsdóttir, M Á Kristinsson, K G Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. |
topic_facet |
Lungnabólga Lyfjagjöf Streptococcus pneumoniae/drug effects* Erythromycin Tetracycline Drug Resistance Bacterial Adolescent Adult Aged 80 and over Child Preschool Electrophoresis Gel Pulsed-Field Female Genotype Humans Iceland/epidemiology Infant Newborn Male Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Penicillin Resistance* Pneumococcal Infections/epidemiology* Pneumococcal Infections/microbiology* Prevalence Serotyping Streptococcus pneumoniae/isolation & purification Young Adult |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page The first penicillin-non-susceptible pneumococci (PNSP) were identified in Iceland in 1988. A rapid increase followed, associated with expansion of a single multiresistant clone, Spain(6B)-2, peaking at 19.8% in 1993. After interventions led to reduced antimicrobial use in children, the prevalence of PNSP decreased until 1995. The aim of this study was to follow the evolution of PNSP from 1995 to 2010, the period preceding the introduction of conjugated pneumococcal vaccines into the vaccination programme. The laboratory at the Landspitali University Hospital serves ∼ 85% of the Icelandic population. All pneumococci isolated from 1995 to 2010 (n = 13,937) were stored (-80 °C). Oxacillin-resistant isolates were serotyped and penicillin MICs were determined. Selected strains were genotyped by PFGE and multilocus sequence typing. In 1995, the rate of PNSP was 24.2%, declining to 13.6% in 2001, and then increasing to 38.6% in 2010. Similar changes were observed for resistance to erythromycin and tetracycline. In 1995, 60.7% of PNSP were serotype 6B, mainly the Spain(6B)-2 clone, declining to 5.7% in 2010. PNSP of serotype 19F rapidly increased after 2004 to comprise 85.8% of all serogrouped PNSP in 2010, with most isolates belonging to a single multiresistant PFGE clone identified as sequence type (ST) 271 and ST1968, representing single- and double-locus variants of the international clone Taiwan(19F)-14, respectively. PNSP were most common among young children, from the nasopharynx, middle ear and lower respiratory tract. The epidemiology of PNSP was dominated by two multiresistant clones. The second expanded rapidly when the first one was disappearing, causing higher antibiotic resistance rates among pneumococci than seen before in Iceland. |
author2 |
a Department of Clinical Microbiology, Landspitali University Hospital, Baronsstig, 101 Reykjavik, Iceland b University of Iceland, Stapi v/Hringbraut, 101 Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Hjálmarsdóttir, M Á Kristinsson, K G |
author_facet |
Hjálmarsdóttir, M Á Kristinsson, K G |
author_sort |
Hjálmarsdóttir, M Á |
title |
Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. |
title_short |
Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. |
title_full |
Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. |
title_fullStr |
Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. |
title_full_unstemmed |
Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010. |
title_sort |
epidemiology of penicillin-non-susceptible pneumococci in iceland, 1995-2010. |
publisher |
Oxford University Press |
publishDate |
2014 |
url |
http://hdl.handle.net/2336/326091 https://doi.org/10.1093/jac/dkt470 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1093/jac/dkt470 J. Antimicrob. Chemother. 2014, 69 (4):940-6 1460-2091 24311742 doi:10.1093/jac/dkt470 http://hdl.handle.net/2336/326091 The Journal of antimicrobial chemotherapy |
op_rights |
Archived with thanks to The Journal of antimicrobial chemotherapy Closed - Lokað |
op_doi |
https://doi.org/10.1093/jac/dkt470 |
container_title |
Journal of Antimicrobial Chemotherapy |
container_volume |
69 |
container_issue |
4 |
container_start_page |
940 |
op_container_end_page |
946 |
_version_ |
1766037316471619584 |