The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Dyspepsia develops in healthy volunteers after withdrawal of proton-pump inhibitors. This phenomenon, attributed to rebound acid hypersecretion, is thought to be mediated by reflex hypergast...
Published in: | Digestive and Liver Disease |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Elsevier Science Ltd.
2014
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Online Access: | http://hdl.handle.net/2336/326077 https://doi.org/10.1016/j.dld.2013.09.021 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/326077 2023-05-15T16:49:08+02:00 The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. Helgadóttir, Hólmfridur Metz, David C Yang, Yu-Xiao Rhim, Andrew D Björnsson, Einar S Univ Iceland, Fac Med, Reykjavik, Iceland, Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA, Natl Univ Hosp Iceland, Dept Internal Med, Div Gastroenterol & Hepatol, Reykjavik, Iceland 2014 http://hdl.handle.net/2336/326077 https://doi.org/10.1016/j.dld.2013.09.021 en eng Elsevier Science Ltd. http://dx.doi.org/10.1016/j.dld.2013.09.021 Dig Liver Dis. 2014, 46 (2):125-30 1878-3562 24210828 doi:10.1016/j.dld.2013.09.021 http://hdl.handle.net/2336/326077 Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Archived with thanks to Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver National Consortium - Landsaðgangur Meltingarfærasjúkdómar Lyfjagjöf Dyspepsia/etiology Proton Pump Inhibitors/adverse effects* Esophagitis Peptic/complications Gastrins/blood* Aged Case-Control Studies Chromogranin A Cross-Sectional Studies Dyspepsia/blood Peptic/drug therapy* Female Helicobacter Infections/complications Helicobacter pylori Humans Male Middle Aged Postprandial Period* Sex Factors Substance Withdrawal Syndrome/etiology* Article 2014 ftlandspitaliuni https://doi.org/10.1016/j.dld.2013.09.021 2022-05-29T08:22:00Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page Dyspepsia develops in healthy volunteers after withdrawal of proton-pump inhibitors. This phenomenon, attributed to rebound acid hypersecretion, is thought to be mediated by reflex hypergastrinemia. To measure fasting and postprandial gastrin in patients on long-term proton-pump inhibitor treatment and correlate gastrin levels with the duration of treatment and other potential predictors. In this cross sectional study patients, with erosive esophagitis, on long-term proton-pump inhibitor treatment and healthy controls underwent gastrin measurements at baseline and four times following a meal and Helicobacter pylori status was determined. A total of 100 patients and 50 controls were studied. Pre- and postprandial gastrin levels were higher in patients (p<0.001). No significant correlation was found between the area under the gastrin-curve and the treatment duration. Female patients had significantly higher gastrin levels than males pre- and postprandial, whereas such differences was not found in the control group. Female gender was the only independent predictor of s-gastrin levels (OR 2.50 compared to males, 95% CI: 1.08-5.76, p=0.032) in the patient group. Gastrin values were higher in patients compared to controls. There was no correlation between gastrin levels and treatment duration. Female patients had significantly higher gastrin values than males. National Institutes of Health/DK088945 DK19525 Penn Radioimmunoassay and Biomarkers Core of the Diabetes Research Center/DK050306 Penn Center for Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core (ADR) Research Fund of the National University Hospital of Iceland University of Iceland Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Digestive and Liver Disease 46 2 125 130 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Meltingarfærasjúkdómar Lyfjagjöf Dyspepsia/etiology Proton Pump Inhibitors/adverse effects* Esophagitis Peptic/complications Gastrins/blood* Aged Case-Control Studies Chromogranin A Cross-Sectional Studies Dyspepsia/blood Peptic/drug therapy* Female Helicobacter Infections/complications Helicobacter pylori Humans Male Middle Aged Postprandial Period* Sex Factors Substance Withdrawal Syndrome/etiology* |
spellingShingle |
Meltingarfærasjúkdómar Lyfjagjöf Dyspepsia/etiology Proton Pump Inhibitors/adverse effects* Esophagitis Peptic/complications Gastrins/blood* Aged Case-Control Studies Chromogranin A Cross-Sectional Studies Dyspepsia/blood Peptic/drug therapy* Female Helicobacter Infections/complications Helicobacter pylori Humans Male Middle Aged Postprandial Period* Sex Factors Substance Withdrawal Syndrome/etiology* Helgadóttir, Hólmfridur Metz, David C Yang, Yu-Xiao Rhim, Andrew D Björnsson, Einar S The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
topic_facet |
Meltingarfærasjúkdómar Lyfjagjöf Dyspepsia/etiology Proton Pump Inhibitors/adverse effects* Esophagitis Peptic/complications Gastrins/blood* Aged Case-Control Studies Chromogranin A Cross-Sectional Studies Dyspepsia/blood Peptic/drug therapy* Female Helicobacter Infections/complications Helicobacter pylori Humans Male Middle Aged Postprandial Period* Sex Factors Substance Withdrawal Syndrome/etiology* |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Dyspepsia develops in healthy volunteers after withdrawal of proton-pump inhibitors. This phenomenon, attributed to rebound acid hypersecretion, is thought to be mediated by reflex hypergastrinemia. To measure fasting and postprandial gastrin in patients on long-term proton-pump inhibitor treatment and correlate gastrin levels with the duration of treatment and other potential predictors. In this cross sectional study patients, with erosive esophagitis, on long-term proton-pump inhibitor treatment and healthy controls underwent gastrin measurements at baseline and four times following a meal and Helicobacter pylori status was determined. A total of 100 patients and 50 controls were studied. Pre- and postprandial gastrin levels were higher in patients (p<0.001). No significant correlation was found between the area under the gastrin-curve and the treatment duration. Female patients had significantly higher gastrin levels than males pre- and postprandial, whereas such differences was not found in the control group. Female gender was the only independent predictor of s-gastrin levels (OR 2.50 compared to males, 95% CI: 1.08-5.76, p=0.032) in the patient group. Gastrin values were higher in patients compared to controls. There was no correlation between gastrin levels and treatment duration. Female patients had significantly higher gastrin values than males. National Institutes of Health/DK088945 DK19525 Penn Radioimmunoassay and Biomarkers Core of the Diabetes Research Center/DK050306 Penn Center for Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core (ADR) Research Fund of the National University Hospital of Iceland University of Iceland Research Fund |
author2 |
Univ Iceland, Fac Med, Reykjavik, Iceland, Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA, Natl Univ Hosp Iceland, Dept Internal Med, Div Gastroenterol & Hepatol, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Helgadóttir, Hólmfridur Metz, David C Yang, Yu-Xiao Rhim, Andrew D Björnsson, Einar S |
author_facet |
Helgadóttir, Hólmfridur Metz, David C Yang, Yu-Xiao Rhim, Andrew D Björnsson, Einar S |
author_sort |
Helgadóttir, Hólmfridur |
title |
The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
title_short |
The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
title_full |
The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
title_fullStr |
The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
title_full_unstemmed |
The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
title_sort |
effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. |
publisher |
Elsevier Science Ltd. |
publishDate |
2014 |
url |
http://hdl.handle.net/2336/326077 https://doi.org/10.1016/j.dld.2013.09.021 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/j.dld.2013.09.021 Dig Liver Dis. 2014, 46 (2):125-30 1878-3562 24210828 doi:10.1016/j.dld.2013.09.021 http://hdl.handle.net/2336/326077 Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver |
op_rights |
Archived with thanks to Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1016/j.dld.2013.09.021 |
container_title |
Digestive and Liver Disease |
container_volume |
46 |
container_issue |
2 |
container_start_page |
125 |
op_container_end_page |
130 |
_version_ |
1766039214882816000 |