Monoclonal gammopathy in Iceland: a population-based registry and follow-up
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The term monoclonal gammopathy (MG) signifies the benign or malignant clonal growth of B lymphocytes. In the present study, monoclonal gammopathy of unknown significance (MGUS) was defined...
Published in: | British Journal of Haematology |
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Online Access: | http://hdl.handle.net/2336/32582 https://doi.org/10.1046/j.1365-2141.2002.03589.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/32582 2023-05-15T16:47:43+02:00 Monoclonal gammopathy in Iceland: a population-based registry and follow-up Ogmundsdottir, Helga M Haraldsdottir, Vilhelmina Johannesson, Gudmundur M Olafsdottir, Gudridur Bjarnadottir, Kristin Sigvaldason, Helgi Tulinius, Hrafn Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Reykjavík, Iceland. helgam@krabb.is 2008-07-21 http://hdl.handle.net/2336/32582 https://doi.org/10.1046/j.1365-2141.2002.03589.x en eng Blackwell Scientific Publications http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=6911350&site=ehost-live Br. J. Haematol. 2002, 118(1):166-73 0007-1048 12100144 doi:10.1046/j.1365-2141.2002.03589.x http://hdl.handle.net/2336/32582 British journal of haematology Adult Age Distribution Aged 80 and over Female Follow-Up Studies Humans Iceland Incidence Male Middle Aged Monoclonal Gammopathies Benign Multiple Myeloma Registries Risk Sex Distribution Waldenstrom Macroglobulinemia Article 2008 ftlandspitaliuni https://doi.org/10.1046/j.1365-2141.2002.03589.x 2022-05-29T08:21:10Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The term monoclonal gammopathy (MG) signifies the benign or malignant clonal growth of B lymphocytes. In the present study, monoclonal gammopathy of unknown significance (MGUS) was defined as those patients with no identified haematological malignancy. A database was constructed of all 713 MG patients in Iceland between 1976 and 1997 and compared with the Icelandic Cancer Registry. The age-standardized incidence per 100 000 of MG was 10.3 for males and 8.6 for females, calculated for the whole period, rising steadily from 5.8 (men) and 4.9 (women) during the 5-year period 1976-80 to 14.7 (men) and 12.5 (women) during the last 5 year period. Age-standardized incidence rates were very low for subjects under 50 years of age, then increased with age from 11 and 17 per 100 000 at 50-54, to 169 and 119 per 100 000 at age 80-84, for men and women respectively. No association was detected between MG and non-haematological malignancies, neither retrospectively nor prospectively. Haematological malignancy was diagnosed in 209 (29.3%) cases before the recorded finding of MG or within the same calendar year, leaving 504 (70.7%) patients diagnosed with MGUS. Of these, 51 (10%) progressed to multiple myeloma or Waldenström's macroglobulinaemia after a mean interval of 3.8 years; mean follow-up was 7.4 years, median 6 years. The most common immunoglobulin (Ig) class was IgG (55%), followed by IgM (32%) and IgA (13%). MGUS was a highly significant risk factor for developing haematological malignancies and the risk was significantly greater for MG of the IgA class compared with either IgG or IgM. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive British Journal of Haematology 118 1 166 173 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adult Age Distribution Aged 80 and over Female Follow-Up Studies Humans Iceland Incidence Male Middle Aged Monoclonal Gammopathies Benign Multiple Myeloma Registries Risk Sex Distribution Waldenstrom Macroglobulinemia |
spellingShingle |
Adult Age Distribution Aged 80 and over Female Follow-Up Studies Humans Iceland Incidence Male Middle Aged Monoclonal Gammopathies Benign Multiple Myeloma Registries Risk Sex Distribution Waldenstrom Macroglobulinemia Ogmundsdottir, Helga M Haraldsdottir, Vilhelmina Johannesson, Gudmundur M Olafsdottir, Gudridur Bjarnadottir, Kristin Sigvaldason, Helgi Tulinius, Hrafn Monoclonal gammopathy in Iceland: a population-based registry and follow-up |
topic_facet |
Adult Age Distribution Aged 80 and over Female Follow-Up Studies Humans Iceland Incidence Male Middle Aged Monoclonal Gammopathies Benign Multiple Myeloma Registries Risk Sex Distribution Waldenstrom Macroglobulinemia |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The term monoclonal gammopathy (MG) signifies the benign or malignant clonal growth of B lymphocytes. In the present study, monoclonal gammopathy of unknown significance (MGUS) was defined as those patients with no identified haematological malignancy. A database was constructed of all 713 MG patients in Iceland between 1976 and 1997 and compared with the Icelandic Cancer Registry. The age-standardized incidence per 100 000 of MG was 10.3 for males and 8.6 for females, calculated for the whole period, rising steadily from 5.8 (men) and 4.9 (women) during the 5-year period 1976-80 to 14.7 (men) and 12.5 (women) during the last 5 year period. Age-standardized incidence rates were very low for subjects under 50 years of age, then increased with age from 11 and 17 per 100 000 at 50-54, to 169 and 119 per 100 000 at age 80-84, for men and women respectively. No association was detected between MG and non-haematological malignancies, neither retrospectively nor prospectively. Haematological malignancy was diagnosed in 209 (29.3%) cases before the recorded finding of MG or within the same calendar year, leaving 504 (70.7%) patients diagnosed with MGUS. Of these, 51 (10%) progressed to multiple myeloma or Waldenström's macroglobulinaemia after a mean interval of 3.8 years; mean follow-up was 7.4 years, median 6 years. The most common immunoglobulin (Ig) class was IgG (55%), followed by IgM (32%) and IgA (13%). MGUS was a highly significant risk factor for developing haematological malignancies and the risk was significantly greater for MG of the IgA class compared with either IgG or IgM. |
author2 |
Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Reykjavík, Iceland. helgam@krabb.is |
format |
Article in Journal/Newspaper |
author |
Ogmundsdottir, Helga M Haraldsdottir, Vilhelmina Johannesson, Gudmundur M Olafsdottir, Gudridur Bjarnadottir, Kristin Sigvaldason, Helgi Tulinius, Hrafn |
author_facet |
Ogmundsdottir, Helga M Haraldsdottir, Vilhelmina Johannesson, Gudmundur M Olafsdottir, Gudridur Bjarnadottir, Kristin Sigvaldason, Helgi Tulinius, Hrafn |
author_sort |
Ogmundsdottir, Helga M |
title |
Monoclonal gammopathy in Iceland: a population-based registry and follow-up |
title_short |
Monoclonal gammopathy in Iceland: a population-based registry and follow-up |
title_full |
Monoclonal gammopathy in Iceland: a population-based registry and follow-up |
title_fullStr |
Monoclonal gammopathy in Iceland: a population-based registry and follow-up |
title_full_unstemmed |
Monoclonal gammopathy in Iceland: a population-based registry and follow-up |
title_sort |
monoclonal gammopathy in iceland: a population-based registry and follow-up |
publisher |
Blackwell Scientific Publications |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/32582 https://doi.org/10.1046/j.1365-2141.2002.03589.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=6911350&site=ehost-live Br. J. Haematol. 2002, 118(1):166-73 0007-1048 12100144 doi:10.1046/j.1365-2141.2002.03589.x http://hdl.handle.net/2336/32582 British journal of haematology |
op_doi |
https://doi.org/10.1046/j.1365-2141.2002.03589.x |
container_title |
British Journal of Haematology |
container_volume |
118 |
container_issue |
1 |
container_start_page |
166 |
op_container_end_page |
173 |
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1766037806533050368 |