Oximetry in glaucoma: correlation of metabolic change with structural and functional damage.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated with structural optic disc and retinal nerve fibre layer (RNFL) changes and visual fiel...
Published in: | Acta Ophthalmologica |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Wiley-Blackwell
2014
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Online Access: | http://hdl.handle.net/2336/325545 https://doi.org/10.1111/aos.12011 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/325545 2023-05-15T16:52:47+02:00 Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. Vandewalle, Evelien Abegão Pinto, L Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg KULeuven, Lab Ophthalmol, Leuven, Belgium Univ Hosp Leuven, Dept Ophthalmol, B-3000 Leuven, Belgium Univ Lisbon, Fac Med, Dept Pharmacol & Neurosci, P-1699 Lisbon, Portugal Ctr Hosp Lisboa Cent, Dept Ophthalmol, Lisbon, Portugal Univ Iceland, Dept Ophthalmol, Reykjavik, Iceland 2014-08-29 http://hdl.handle.net/2336/325545 https://doi.org/10.1111/aos.12011 en eng Wiley-Blackwell http://dx.doi.org/10.1111/aos.12011 http://onlinelibrary.wiley.com/doi/10.1111/aos.12011/pdf Acta Ophthalmol 2014, 92(2):105-10 1755-3768 23323611 doi:10.1111/aos.12011 http://hdl.handle.net/2336/325545 Acta ophthalmologica Archived with thanks to Acta ophthalmologica National Consortium - Landsaðgangur Blood Pressure Female Glaucoma Open-Angle Humans Intraocular Pressure Male Middle Aged Nerve Fibers Optic Disk Oximetry Oxygen Oxygen Consumption Partial Pressure Prospective Studies Retinal Ganglion Cells Retinal Vessels Tomography Tonometry Ocular Vision Disorders Visual Field Tests Visual Fields Article 2014 ftlandspitaliuni https://doi.org/10.1111/aos.12011 2022-05-29T08:21:59Z To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated with structural optic disc and retinal nerve fibre layer (RNFL) changes and visual field (VF) defects. Fifty-nine patients with confirmed glaucoma were recruited at University Hospitals Leuven. Retinal oxygen saturation in patients with glaucoma was measured with a noninvasive spectrophotometric retinal oximeter (Oxymap ehf, Reykjavik, Iceland). VF and Heidelberg retinal tomographies (HRTs) were performed on the same day. Statistical analysis was performed using Student's t-test and Pearson's or Spearman correlation coefficient. The mean oxygen saturation in venules was higher in patients with severe VF defects compared to those patients with mild VF defects (69 ± 3% versus 65 ± 6% respectively; p = 0.0003; n = 59). Accordingly, the arteriovenous (AV) difference in oxygen saturation was lower in patients with worse VF compared to those with better VF (29 ± 3% versus 33 ± 6% respectively; p = 0.002). The oxygen saturation in venules correlated with the VF mean defects (r = -0.42; p = 0.001; n = 59) as well as with the structural HRT parameters rim area and RNFL thickness (r = -0.39; p = 0.008 and r = -0.26; p = 0.05 respectively; n = 53). The AV difference decreased significantly as the VF defect worsened (r = 0.38; p = 0.003), as the rim area diminished (r = 0.29; p = 0.03) and as the RNFL thickness decreased (r = 0.27; p = 0.05). No correlation was found between the oxygen saturation in retinal arterioles and either of these parameters. Severe glaucomatous damage is associated with increased oxygen saturation in retinal venules and decreased AV difference in oxygen saturation. These data suggest that in eyes with severe glaucomatous damage, reduced retinal oxygen consumption is consistent with tissue loss. FWO 'Fonds Wetenschappelijk Onderzoek - Vlaanderen' MSD Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Acta Ophthalmologica 92 2 105 110 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Blood Pressure Female Glaucoma Open-Angle Humans Intraocular Pressure Male Middle Aged Nerve Fibers Optic Disk Oximetry Oxygen Oxygen Consumption Partial Pressure Prospective Studies Retinal Ganglion Cells Retinal Vessels Tomography Tonometry Ocular Vision Disorders Visual Field Tests Visual Fields |
spellingShingle |
Blood Pressure Female Glaucoma Open-Angle Humans Intraocular Pressure Male Middle Aged Nerve Fibers Optic Disk Oximetry Oxygen Oxygen Consumption Partial Pressure Prospective Studies Retinal Ganglion Cells Retinal Vessels Tomography Tonometry Ocular Vision Disorders Visual Field Tests Visual Fields Vandewalle, Evelien Abegão Pinto, L Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
topic_facet |
Blood Pressure Female Glaucoma Open-Angle Humans Intraocular Pressure Male Middle Aged Nerve Fibers Optic Disk Oximetry Oxygen Oxygen Consumption Partial Pressure Prospective Studies Retinal Ganglion Cells Retinal Vessels Tomography Tonometry Ocular Vision Disorders Visual Field Tests Visual Fields |
description |
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated with structural optic disc and retinal nerve fibre layer (RNFL) changes and visual field (VF) defects. Fifty-nine patients with confirmed glaucoma were recruited at University Hospitals Leuven. Retinal oxygen saturation in patients with glaucoma was measured with a noninvasive spectrophotometric retinal oximeter (Oxymap ehf, Reykjavik, Iceland). VF and Heidelberg retinal tomographies (HRTs) were performed on the same day. Statistical analysis was performed using Student's t-test and Pearson's or Spearman correlation coefficient. The mean oxygen saturation in venules was higher in patients with severe VF defects compared to those patients with mild VF defects (69 ± 3% versus 65 ± 6% respectively; p = 0.0003; n = 59). Accordingly, the arteriovenous (AV) difference in oxygen saturation was lower in patients with worse VF compared to those with better VF (29 ± 3% versus 33 ± 6% respectively; p = 0.002). The oxygen saturation in venules correlated with the VF mean defects (r = -0.42; p = 0.001; n = 59) as well as with the structural HRT parameters rim area and RNFL thickness (r = -0.39; p = 0.008 and r = -0.26; p = 0.05 respectively; n = 53). The AV difference decreased significantly as the VF defect worsened (r = 0.38; p = 0.003), as the rim area diminished (r = 0.29; p = 0.03) and as the RNFL thickness decreased (r = 0.27; p = 0.05). No correlation was found between the oxygen saturation in retinal arterioles and either of these parameters. Severe glaucomatous damage is associated with increased oxygen saturation in retinal venules and decreased AV difference in oxygen saturation. These data suggest that in eyes with severe glaucomatous damage, reduced retinal oxygen consumption is consistent with tissue loss. FWO 'Fonds Wetenschappelijk Onderzoek - Vlaanderen' MSD |
author2 |
KULeuven, Lab Ophthalmol, Leuven, Belgium Univ Hosp Leuven, Dept Ophthalmol, B-3000 Leuven, Belgium Univ Lisbon, Fac Med, Dept Pharmacol & Neurosci, P-1699 Lisbon, Portugal Ctr Hosp Lisboa Cent, Dept Ophthalmol, Lisbon, Portugal Univ Iceland, Dept Ophthalmol, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Vandewalle, Evelien Abegão Pinto, L Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg |
author_facet |
Vandewalle, Evelien Abegão Pinto, L Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg |
author_sort |
Vandewalle, Evelien |
title |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
title_short |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
title_full |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
title_fullStr |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
title_full_unstemmed |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
title_sort |
oximetry in glaucoma: correlation of metabolic change with structural and functional damage. |
publisher |
Wiley-Blackwell |
publishDate |
2014 |
url |
http://hdl.handle.net/2336/325545 https://doi.org/10.1111/aos.12011 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/aos.12011 http://onlinelibrary.wiley.com/doi/10.1111/aos.12011/pdf Acta Ophthalmol 2014, 92(2):105-10 1755-3768 23323611 doi:10.1111/aos.12011 http://hdl.handle.net/2336/325545 Acta ophthalmologica |
op_rights |
Archived with thanks to Acta ophthalmologica National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1111/aos.12011 |
container_title |
Acta Ophthalmologica |
container_volume |
92 |
container_issue |
2 |
container_start_page |
105 |
op_container_end_page |
110 |
_version_ |
1766043190296576000 |