Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Open heart surgery is associated with a systemic inflammatory response. The n-3 long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA),...

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Published in:Prostaglandins, Leukotrienes and Essential Fatty Acids
Main Authors: Bjorgvinsdottir, L, Indridason, O S, Heidarsdottir, R, Skogstrand, K, Arnar, D O, Torfason, B, Hougaard, D M, Palsson, R, Skuladottir, G V
Other Authors: Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Internal Med Serv, IS-101 Reykjavik, Iceland, Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark, Landspitali Natl Univ Hosp Iceland, Cardiovasc Res Ctr, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier Science 2013
Subjects:
Online Access:http://hdl.handle.net/2336/324722
https://doi.org/10.1016/j.plefa.2013.07.007
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spelling ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/324722 2023-05-15T16:48:32+02:00 Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. Bjorgvinsdottir, L Indridason, O S Heidarsdottir, R Skogstrand, K Arnar, D O Torfason, B Hougaard, D M Palsson, R Skuladottir, G V Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Internal Med Serv, IS-101 Reykjavik, Iceland, Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark, Landspitali Natl Univ Hosp Iceland, Cardiovasc Res Ctr, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland 2013 http://hdl.handle.net/2336/324722 https://doi.org/10.1016/j.plefa.2013.07.007 en eng Elsevier Science http://dx.doi.org/10.1016/j.plefa.2013.07.007 http://ac.els-cdn.com/S0952327813001579/1-s2.0-S0952327813001579-main.pdf?_tid=4708f0f4-222c-11e4-b5ac-00000aacb35f&acdnat=1407853609_5dc339ee7a7a0cb1edbec315f969dff9 Prostaglandins Leukot. Essent. Fatty Acids 2013, 89 (4):189-94 1532-2823 23999253 doi:10.1016/j.plefa.2013.07.007 http://hdl.handle.net/2336/324722 Prostaglandins, leukotrienes, and essential fatty acids Archived with thanks to Prostaglandins, leukotrienes, and essential fatty acids National Consortium - Landsaðgangur Hjartasjúkdómar Hjartaaðgerðir Gáttatif Adult Aged 80 and over Arachidonic Acid Atrial Fibrillation Cardiac Surgical Procedures Cell Membrane Chemokines Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid Erythrocytes Fatty Acids Omega-3 Female Heart Diseases Humans Male Middle Aged Phospholipids Postoperative Complications Postoperative Period Preoperative Period Randomized Controlled Trials as Topic Treatment Outcome Article 2013 ftlandspitaliuni https://doi.org/10.1016/j.plefa.2013.07.007 2022-05-29T08:21:58Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page Open heart surgery is associated with a systemic inflammatory response. The n-3 long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the n-6 LC-PUFA arachidonic acid (AA) may contribute to modulation of the inflammatory response. We investigated whether the preoperative levels of EPA, DHA and AA in plasma phospholipids (PL) and red blood cell (RBC) membrane lipids in patients (n=168) undergoing open heart surgery were associated with changes in the plasma concentration of selected inflammatory mediators in the immediate postoperative period. The postoperative concentration of TNF-β was lower (P<0.05) and those of hs-CRP, IL-6, IL-8, IL-18 and IL-10 higher (P<0.05) than the respective preoperative concentrations. We observed that the preoperative levels of EPA and AA in plasma PL and RBC membrane lipids were associated with changes in the concentration of pro-inflammatory and anti-inflammatory mediators, suggesting a complex role in the postoperative inflammatory process. Icelandic Research Fund (RANNIS)/080411021 University of Iceland Research Fund Landspitali-The National University Hospital of Iceland Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Prostaglandins, Leukotrienes and Essential Fatty Acids 89 4 189 194
institution Open Polar
collection Hirsla - Landspítali University Hospital research archive
op_collection_id ftlandspitaliuni
language English
topic Hjartasjúkdómar
Hjartaaðgerðir
Gáttatif
Adult
Aged
80 and over
Arachidonic Acid
Atrial Fibrillation
Cardiac Surgical Procedures
Cell Membrane
Chemokines
Docosahexaenoic Acids
Double-Blind Method
Eicosapentaenoic Acid
Erythrocytes
Fatty Acids
Omega-3
Female
Heart Diseases
Humans
Male
Middle Aged
Phospholipids
Postoperative Complications
Postoperative Period
Preoperative Period
Randomized Controlled Trials as Topic
Treatment Outcome
spellingShingle Hjartasjúkdómar
Hjartaaðgerðir
Gáttatif
Adult
Aged
80 and over
Arachidonic Acid
Atrial Fibrillation
Cardiac Surgical Procedures
Cell Membrane
Chemokines
Docosahexaenoic Acids
Double-Blind Method
Eicosapentaenoic Acid
Erythrocytes
Fatty Acids
Omega-3
Female
Heart Diseases
Humans
Male
Middle Aged
Phospholipids
Postoperative Complications
Postoperative Period
Preoperative Period
Randomized Controlled Trials as Topic
Treatment Outcome
Bjorgvinsdottir, L
Indridason, O S
Heidarsdottir, R
Skogstrand, K
Arnar, D O
Torfason, B
Hougaard, D M
Palsson, R
Skuladottir, G V
Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
topic_facet Hjartasjúkdómar
Hjartaaðgerðir
Gáttatif
Adult
Aged
80 and over
Arachidonic Acid
Atrial Fibrillation
Cardiac Surgical Procedures
Cell Membrane
Chemokines
Docosahexaenoic Acids
Double-Blind Method
Eicosapentaenoic Acid
Erythrocytes
Fatty Acids
Omega-3
Female
Heart Diseases
Humans
Male
Middle Aged
Phospholipids
Postoperative Complications
Postoperative Period
Preoperative Period
Randomized Controlled Trials as Topic
Treatment Outcome
description To access publisher's full text version of this article click on the hyperlink at the bottom of the page Open heart surgery is associated with a systemic inflammatory response. The n-3 long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the n-6 LC-PUFA arachidonic acid (AA) may contribute to modulation of the inflammatory response. We investigated whether the preoperative levels of EPA, DHA and AA in plasma phospholipids (PL) and red blood cell (RBC) membrane lipids in patients (n=168) undergoing open heart surgery were associated with changes in the plasma concentration of selected inflammatory mediators in the immediate postoperative period. The postoperative concentration of TNF-β was lower (P<0.05) and those of hs-CRP, IL-6, IL-8, IL-18 and IL-10 higher (P<0.05) than the respective preoperative concentrations. We observed that the preoperative levels of EPA and AA in plasma PL and RBC membrane lipids were associated with changes in the concentration of pro-inflammatory and anti-inflammatory mediators, suggesting a complex role in the postoperative inflammatory process. Icelandic Research Fund (RANNIS)/080411021 University of Iceland Research Fund Landspitali-The National University Hospital of Iceland Research Fund
author2 Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Internal Med Serv, IS-101 Reykjavik, Iceland, Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark, Landspitali Natl Univ Hosp Iceland, Cardiovasc Res Ctr, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland
format Article in Journal/Newspaper
author Bjorgvinsdottir, L
Indridason, O S
Heidarsdottir, R
Skogstrand, K
Arnar, D O
Torfason, B
Hougaard, D M
Palsson, R
Skuladottir, G V
author_facet Bjorgvinsdottir, L
Indridason, O S
Heidarsdottir, R
Skogstrand, K
Arnar, D O
Torfason, B
Hougaard, D M
Palsson, R
Skuladottir, G V
author_sort Bjorgvinsdottir, L
title Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
title_short Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
title_full Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
title_fullStr Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
title_full_unstemmed Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
title_sort inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
publisher Elsevier Science
publishDate 2013
url http://hdl.handle.net/2336/324722
https://doi.org/10.1016/j.plefa.2013.07.007
genre Iceland
genre_facet Iceland
op_relation http://dx.doi.org/10.1016/j.plefa.2013.07.007
http://ac.els-cdn.com/S0952327813001579/1-s2.0-S0952327813001579-main.pdf?_tid=4708f0f4-222c-11e4-b5ac-00000aacb35f&acdnat=1407853609_5dc339ee7a7a0cb1edbec315f969dff9
Prostaglandins Leukot. Essent. Fatty Acids 2013, 89 (4):189-94
1532-2823
23999253
doi:10.1016/j.plefa.2013.07.007
http://hdl.handle.net/2336/324722
Prostaglandins, leukotrienes, and essential fatty acids
op_rights Archived with thanks to Prostaglandins, leukotrienes, and essential fatty acids
National Consortium - Landsaðgangur
op_doi https://doi.org/10.1016/j.plefa.2013.07.007
container_title Prostaglandins, Leukotrienes and Essential Fatty Acids
container_volume 89
container_issue 4
container_start_page 189
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