Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Open heart surgery is associated with a systemic inflammatory response. The n-3 long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA),...

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Bibliographic Details
Published in:Prostaglandins, Leukotrienes and Essential Fatty Acids
Main Authors: Bjorgvinsdottir, L, Indridason, O S, Heidarsdottir, R, Skogstrand, K, Arnar, D O, Torfason, B, Hougaard, D M, Palsson, R, Skuladottir, G V
Other Authors: Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Internal Med Serv, IS-101 Reykjavik, Iceland, Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark, Landspitali Natl Univ Hosp Iceland, Cardiovasc Res Ctr, IS-101 Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier Science 2013
Subjects:
Hjartasjúkdómar
Hjartaaðgerðir
Gáttatif
Adult
Aged
80 and over
Arachidonic Acid
Atrial Fibrillation
Cardiac Surgical Procedures
Cell Membrane
Chemokines
Docosahexaenoic Acids
Double-Blind Method
Eicosapentaenoic Acid
Erythrocytes
Fatty Acids
Omega-3
Female
Heart Diseases
Humans
Male
Middle Aged
Phospholipids
Postoperative Complications
Postoperative Period
Preoperative Period
Randomized Controlled Trials as Topic
Treatment Outcome
Iceland
Online Access:http://hdl.handle.net/2336/324722
https://doi.org/10.1016/j.plefa.2013.07.007
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Summary:To access publisher's full text version of this article click on the hyperlink at the bottom of the page Open heart surgery is associated with a systemic inflammatory response. The n-3 long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the n-6 LC-PUFA arachidonic acid (AA) may contribute to modulation of the inflammatory response. We investigated whether the preoperative levels of EPA, DHA and AA in plasma phospholipids (PL) and red blood cell (RBC) membrane lipids in patients (n=168) undergoing open heart surgery were associated with changes in the plasma concentration of selected inflammatory mediators in the immediate postoperative period. The postoperative concentration of TNF-β was lower (P<0.05) and those of hs-CRP, IL-6, IL-8, IL-18 and IL-10 higher (P<0.05) than the respective preoperative concentrations. We observed that the preoperative levels of EPA and AA in plasma PL and RBC membrane lipids were associated with changes in the concentration of pro-inflammatory and anti-inflammatory mediators, suggesting a complex role in the postoperative inflammatory process. Icelandic Research Fund (RANNIS)/080411021 University of Iceland Research Fund Landspitali-The National University Hospital of Iceland Research Fund

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