Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation?
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Postoperative atrial fibrillation (POAF) has been associated with an inflammatory response to the surgical procedure. n-3 long-chain polyunsaturated fatty acids (LC-PUFA) have been proposed...
Published in: | Cardiology |
---|---|
Main Authors: | , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Karger
2013
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/324701 https://doi.org/10.1159/000351432 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/324701 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/324701 2023-05-15T16:49:08+02:00 Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? Bjorgvinsdottir, Lara Arnar, David O Indridason, Olafur S Heidarsdottir, Ragnhildur Skogstrand, Kristin Torfason, Bjarni Hougaard, David M Palsson, Runolfur Skuladottir, Gudrun V School of Health Sciences, University of Iceland, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark 2013 http://hdl.handle.net/2336/324701 https://doi.org/10.1159/000351432 en eng Karger http://dx.doi.org/10.1159/000351432 http://www.karger.com/Article/Pdf/351432 Cardiology 2013, 126 (2):107-14 1421-9751 23948862 doi:10.1159/000351432 http://hdl.handle.net/2336/324701 Cardiology Archived with thanks to Cardiology National Consortium - Landsaðgangur Hjartaaðgerðir Gáttatif Aged Atrial Fibrillation Cardiopulmonary Bypass Cytokines Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid Erythrocyte Membrane Fatty Acids Omega-3 Female Humans Male Middle Aged Postoperative Complications Preoperative Care Prospective Studies Risk Factors Article 2013 ftlandspitaliuni https://doi.org/10.1159/000351432 2022-05-29T08:21:58Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page Postoperative atrial fibrillation (POAF) has been associated with an inflammatory response to the surgical procedure. n-3 long-chain polyunsaturated fatty acids (LC-PUFA) have been proposed for the prevention of POAF. We investigated the relationship between the plasma concentration of inflammatory mediators, levels of n-3 LC-PUFA in red blood cell (RBC) membrane lipids, and the risk of POAF after coronary artery bypass grafting (CABG). A total of 125 patients who underwent CABG were studied. Inflammatory mediators in plasma and the content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in RBC membranes were assessed. Sixty-two patients (49.6%) developed POAF. The POAF group had higher RBC levels of total n-3 LC-PUFA and DHA than did patients remaining in sinus rhythm (p < 0.05). Of the inflammatory mediators, only postoperative interleukin-6 levels differed, being higher in the POAF group (p < 0.05). Inflammatory mediators were not independent predictors of POAF by multivariable logistic regression analysis. Higher levels of DHA and total n-3 LC-PUFA in RBC membranes, measured immediately prior to CABG and on postoperative day 3, were linearly associated with an increased risk of POAF (p < 0.05). Our findings suggest that inflammatory mediators are not associated with the occurrence of POAF. Interestingly, high n-3 LC-PUFA levels in RBC membranes appear to increase the risk of POAF. Icelandic Centre for Research (RANNIS/080411021, University of Iceland Research Fund, Landspitali - The National University Hospital of Iceland Research Fund. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Cardiology 126 2 107 114 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Hjartaaðgerðir Gáttatif Aged Atrial Fibrillation Cardiopulmonary Bypass Cytokines Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid Erythrocyte Membrane Fatty Acids Omega-3 Female Humans Male Middle Aged Postoperative Complications Preoperative Care Prospective Studies Risk Factors |
spellingShingle |
Hjartaaðgerðir Gáttatif Aged Atrial Fibrillation Cardiopulmonary Bypass Cytokines Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid Erythrocyte Membrane Fatty Acids Omega-3 Female Humans Male Middle Aged Postoperative Complications Preoperative Care Prospective Studies Risk Factors Bjorgvinsdottir, Lara Arnar, David O Indridason, Olafur S Heidarsdottir, Ragnhildur Skogstrand, Kristin Torfason, Bjarni Hougaard, David M Palsson, Runolfur Skuladottir, Gudrun V Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
topic_facet |
Hjartaaðgerðir Gáttatif Aged Atrial Fibrillation Cardiopulmonary Bypass Cytokines Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid Erythrocyte Membrane Fatty Acids Omega-3 Female Humans Male Middle Aged Postoperative Complications Preoperative Care Prospective Studies Risk Factors |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Postoperative atrial fibrillation (POAF) has been associated with an inflammatory response to the surgical procedure. n-3 long-chain polyunsaturated fatty acids (LC-PUFA) have been proposed for the prevention of POAF. We investigated the relationship between the plasma concentration of inflammatory mediators, levels of n-3 LC-PUFA in red blood cell (RBC) membrane lipids, and the risk of POAF after coronary artery bypass grafting (CABG). A total of 125 patients who underwent CABG were studied. Inflammatory mediators in plasma and the content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in RBC membranes were assessed. Sixty-two patients (49.6%) developed POAF. The POAF group had higher RBC levels of total n-3 LC-PUFA and DHA than did patients remaining in sinus rhythm (p < 0.05). Of the inflammatory mediators, only postoperative interleukin-6 levels differed, being higher in the POAF group (p < 0.05). Inflammatory mediators were not independent predictors of POAF by multivariable logistic regression analysis. Higher levels of DHA and total n-3 LC-PUFA in RBC membranes, measured immediately prior to CABG and on postoperative day 3, were linearly associated with an increased risk of POAF (p < 0.05). Our findings suggest that inflammatory mediators are not associated with the occurrence of POAF. Interestingly, high n-3 LC-PUFA levels in RBC membranes appear to increase the risk of POAF. Icelandic Centre for Research (RANNIS/080411021, University of Iceland Research Fund, Landspitali - The National University Hospital of Iceland Research Fund. |
author2 |
School of Health Sciences, University of Iceland, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark |
format |
Article in Journal/Newspaper |
author |
Bjorgvinsdottir, Lara Arnar, David O Indridason, Olafur S Heidarsdottir, Ragnhildur Skogstrand, Kristin Torfason, Bjarni Hougaard, David M Palsson, Runolfur Skuladottir, Gudrun V |
author_facet |
Bjorgvinsdottir, Lara Arnar, David O Indridason, Olafur S Heidarsdottir, Ragnhildur Skogstrand, Kristin Torfason, Bjarni Hougaard, David M Palsson, Runolfur Skuladottir, Gudrun V |
author_sort |
Bjorgvinsdottir, Lara |
title |
Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
title_short |
Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
title_full |
Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
title_fullStr |
Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
title_full_unstemmed |
Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
title_sort |
do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? |
publisher |
Karger |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/324701 https://doi.org/10.1159/000351432 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1159/000351432 http://www.karger.com/Article/Pdf/351432 Cardiology 2013, 126 (2):107-14 1421-9751 23948862 doi:10.1159/000351432 http://hdl.handle.net/2336/324701 Cardiology |
op_rights |
Archived with thanks to Cardiology National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1159/000351432 |
container_title |
Cardiology |
container_volume |
126 |
container_issue |
2 |
container_start_page |
107 |
op_container_end_page |
114 |
_version_ |
1766039214342799360 |