Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Atrial fibrillation (AF) has been associated with cognitive decline independent of stroke,...
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Lippincott Williams & Wilkins
2013
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Online Access: | http://hdl.handle.net/2336/324518 https://doi.org/10.1161/STROKEAHA.12.679381 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/324518 2023-05-15T16:52:47+02:00 Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. Stefansdottir, Hrafnhildur Arnar, David O Aspelund, Thor Sigurdsson, Sigurdur Jonsdottir, Maria K Hjaltason, Haukur Launer, Lenore J Gudnason, Vilmundur Univ Iceland, Fac Med, Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Dept Med, Cardiovasc Res Ctr, IS-101 Reykjavik, Iceland, Iceland Heart Assoc, Kopavogur, Iceland, Univ Iceland, Fac Psychol, Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Dept Neurol, IS-101 Reykjavik, Iceland, NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA, Univ Iowa Hosp & Clin, Dept Internal Med, Iowa City, IA 52242 USA 2013 http://hdl.handle.net/2336/324518 https://doi.org/10.1161/STROKEAHA.12.679381 en eng Lippincott Williams & Wilkins http://dx.doi.org/10.1161/STROKEAHA.12.679381 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632359/ Stroke 2013, 44 (4):1020-5 1524-4628 23444303 doi:10.1161/STROKEAHA.12.679381 http://hdl.handle.net/2336/324518 Stroke; a journal of cerebral circulation openAccess Open Access Gáttatif Heilablóðfall Minni Heilabilun Aged 80 and over Atrial Fibrillation Brain Cerebral Infarction Cognition Cognition Disorders Cohort Studies Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Magnetic Resonance Imaging Male Outcome Assessment (Health Care) Regression Analysis Risk Factors Article 2013 ftlandspitaliuni https://doi.org/10.1161/STROKEAHA.12.679381 2022-05-29T08:21:58Z To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Atrial fibrillation (AF) has been associated with cognitive decline independent of stroke, suggesting additional effects of AF on the brain. We aimed to assess the association between AF and brain function and structure in a general elderly population. This is a cross-sectional analysis of 4251 nondemented participants (mean age, 76 ± 5 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study. Medical record data were collected for the presence, subtype, and time from first diagnosis of AF; 330 participants had AF. Brain volume measurements, adjusted for intracranial volume, and presence of cerebral infarcts were determined with magnetic resonance imaging. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. In a multivariable linear regression model, adjustments were made for demographic factors, cardiovascular risk factors, and cerebral infarcts. Participants with AF had lower total brain volume compared with those without AF (P<0.001). The association was stronger with persistent/permanent than paroxysmal AF and with increased time from the first diagnosis of the disease. Of the brain tissue volumes, AF was associated with lower volume of gray and white matter hyperintensities (P<0.001 and P = 0.008, respectively), but not of white matter hyperintensities (P = 0.49). Participants with AF scored lower on tests of memory. AF is associated with smaller brain volume, and the association is stronger with increasing burden of the arrhythmia. These findings suggest that AF has a cumulative negative effect on the brain independent of cerebral infarcts. Landspitali National University Hospital of Iceland Science Fund Helga Jonsdottir and Sigvaldi Kristjansson Memorial Fund National Institutes of Health/N01-AG-1-2100 ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Stroke 44 4 1020 1025 |
institution |
Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Gáttatif Heilablóðfall Minni Heilabilun Aged 80 and over Atrial Fibrillation Brain Cerebral Infarction Cognition Cognition Disorders Cohort Studies Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Magnetic Resonance Imaging Male Outcome Assessment (Health Care) Regression Analysis Risk Factors |
spellingShingle |
Gáttatif Heilablóðfall Minni Heilabilun Aged 80 and over Atrial Fibrillation Brain Cerebral Infarction Cognition Cognition Disorders Cohort Studies Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Magnetic Resonance Imaging Male Outcome Assessment (Health Care) Regression Analysis Risk Factors Stefansdottir, Hrafnhildur Arnar, David O Aspelund, Thor Sigurdsson, Sigurdur Jonsdottir, Maria K Hjaltason, Haukur Launer, Lenore J Gudnason, Vilmundur Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
topic_facet |
Gáttatif Heilablóðfall Minni Heilabilun Aged 80 and over Atrial Fibrillation Brain Cerebral Infarction Cognition Cognition Disorders Cohort Studies Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Magnetic Resonance Imaging Male Outcome Assessment (Health Care) Regression Analysis Risk Factors |
description |
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Atrial fibrillation (AF) has been associated with cognitive decline independent of stroke, suggesting additional effects of AF on the brain. We aimed to assess the association between AF and brain function and structure in a general elderly population. This is a cross-sectional analysis of 4251 nondemented participants (mean age, 76 ± 5 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study. Medical record data were collected for the presence, subtype, and time from first diagnosis of AF; 330 participants had AF. Brain volume measurements, adjusted for intracranial volume, and presence of cerebral infarcts were determined with magnetic resonance imaging. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. In a multivariable linear regression model, adjustments were made for demographic factors, cardiovascular risk factors, and cerebral infarcts. Participants with AF had lower total brain volume compared with those without AF (P<0.001). The association was stronger with persistent/permanent than paroxysmal AF and with increased time from the first diagnosis of the disease. Of the brain tissue volumes, AF was associated with lower volume of gray and white matter hyperintensities (P<0.001 and P = 0.008, respectively), but not of white matter hyperintensities (P = 0.49). Participants with AF scored lower on tests of memory. AF is associated with smaller brain volume, and the association is stronger with increasing burden of the arrhythmia. These findings suggest that AF has a cumulative negative effect on the brain independent of cerebral infarcts. Landspitali National University Hospital of Iceland Science Fund Helga Jonsdottir and Sigvaldi Kristjansson Memorial Fund National Institutes of Health/N01-AG-1-2100 ... |
author2 |
Univ Iceland, Fac Med, Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Dept Med, Cardiovasc Res Ctr, IS-101 Reykjavik, Iceland, Iceland Heart Assoc, Kopavogur, Iceland, Univ Iceland, Fac Psychol, Reykjavik, Iceland, Landspitali Natl Univ Hosp Iceland, Dept Neurol, IS-101 Reykjavik, Iceland, NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA, Univ Iowa Hosp & Clin, Dept Internal Med, Iowa City, IA 52242 USA |
format |
Article in Journal/Newspaper |
author |
Stefansdottir, Hrafnhildur Arnar, David O Aspelund, Thor Sigurdsson, Sigurdur Jonsdottir, Maria K Hjaltason, Haukur Launer, Lenore J Gudnason, Vilmundur |
author_facet |
Stefansdottir, Hrafnhildur Arnar, David O Aspelund, Thor Sigurdsson, Sigurdur Jonsdottir, Maria K Hjaltason, Haukur Launer, Lenore J Gudnason, Vilmundur |
author_sort |
Stefansdottir, Hrafnhildur |
title |
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
title_short |
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
title_full |
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
title_fullStr |
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
title_full_unstemmed |
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
title_sort |
atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/324518 https://doi.org/10.1161/STROKEAHA.12.679381 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1161/STROKEAHA.12.679381 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632359/ Stroke 2013, 44 (4):1020-5 1524-4628 23444303 doi:10.1161/STROKEAHA.12.679381 http://hdl.handle.net/2336/324518 Stroke; a journal of cerebral circulation |
op_rights |
openAccess Open Access |
op_doi |
https://doi.org/10.1161/STROKEAHA.12.679381 |
container_title |
Stroke |
container_volume |
44 |
container_issue |
4 |
container_start_page |
1020 |
op_container_end_page |
1025 |
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1766043189780676608 |