Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Studies on coronary risk factors in men and women are mainly based on mortality data and few compare results of both sexes with consistent study design and diagnostic criteria....
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2008
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/32434 2023-05-15T16:52:47+02:00 Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. Jonsdottir, Lilja S Sigfusson, Nikulas Gudnason, Vilmundur Sigvaldason, Helgi Thorgeirsson, Gudmundur Heart Preventive Clinic, Icelandic Heart Association, Holtasmári 1, 201 Kópavogur, Iceland, University Hospital, Hringbraut, 101 Reykjavík, Iceland. 2008-07-18 http://hdl.handle.net/2336/32434 en eng Lippincott Williams & Wilkins http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00043798-200204000-00001&LSLINK=80&D=ovft J Cardiovasc Risk. 2002, 9(2):67-76 1350-6277 12006913 http://hdl.handle.net/2336/32434 Journal of cardiovascular risk Adult Age Factors Biological Markers Blood Glucose Blood Pressure Cohort Studies Diabetes Complications Diabetes Mellitus Electrocardiography Endpoint Determination Female Follow-Up Studies Humans Hypertrophy Left Ventricular Iceland Lipids Male Middle Aged Multivariate Analysis Myocardial Infarction Prospective Studies Risk Factors Sex Factors Smoking Women's Health Article 2008 ftlandspitaliuni 2022-05-29T08:21:10Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Studies on coronary risk factors in men and women are mainly based on mortality data and few compare results of both sexes with consistent study design and diagnostic criteria. This study assesses the major risk factors for coronary events in men and women from the Reykjavik Study. DESIGN: Within a prospective, population-based cohort study individuals without history of myocardial infarction were identified and the relative risk of baseline variables was assessed in relation to verified myocardial infarction or coronary death during follow-up. METHODS: Of the 9681 women and 8888 men who attended risk assessment from 1967-1991, with follow-up period of up to 28 years, 706 women and 1700 men suffered a non-fatal myocardial infarction or coronary death. RESULTS: Serum cholesterol was a significant risk factor for both sexes, with hazard ratios (HR) decreasing with age. Systolic blood pressure was a stronger risk factor for women as was ECG-confirmed left ventricular hypertrophy (women HR 2.89, 95% confidence interval [CI] 1.67-5.01; men HR 1.11 [CI 0.86-1.43]). Fasting blood glucose > or =6.7 mmol/L identified significantly higher risk for women (HR 2.65) than men (HR 2.08) as did self-reported diabetes. Triglyceride risk was significantly higher for women and decreased significantly with age. Smoking increased risk two- to five-fold, increasing with dose, for women, which was significantly higher than the doubling in risk for men. CONCLUSIONS: This large study of the major risk factors compared between the sexes demonstrates similar relative risk of myocardial infarction associated with cholesterol for both sexes, however, the relative risk is higher in women for many other risk factors such as smoking, diabetes, elevated triglycerides and left ventricular hypertrophy. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Age Factors Biological Markers Blood Glucose Blood Pressure Cohort Studies Diabetes Complications Diabetes Mellitus Electrocardiography Endpoint Determination Female Follow-Up Studies Humans Hypertrophy Left Ventricular Iceland Lipids Male Middle Aged Multivariate Analysis Myocardial Infarction Prospective Studies Risk Factors Sex Factors Smoking Women's Health |
spellingShingle |
Adult Age Factors Biological Markers Blood Glucose Blood Pressure Cohort Studies Diabetes Complications Diabetes Mellitus Electrocardiography Endpoint Determination Female Follow-Up Studies Humans Hypertrophy Left Ventricular Iceland Lipids Male Middle Aged Multivariate Analysis Myocardial Infarction Prospective Studies Risk Factors Sex Factors Smoking Women's Health Jonsdottir, Lilja S Sigfusson, Nikulas Gudnason, Vilmundur Sigvaldason, Helgi Thorgeirsson, Gudmundur Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. |
topic_facet |
Adult Age Factors Biological Markers Blood Glucose Blood Pressure Cohort Studies Diabetes Complications Diabetes Mellitus Electrocardiography Endpoint Determination Female Follow-Up Studies Humans Hypertrophy Left Ventricular Iceland Lipids Male Middle Aged Multivariate Analysis Myocardial Infarction Prospective Studies Risk Factors Sex Factors Smoking Women's Health |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Studies on coronary risk factors in men and women are mainly based on mortality data and few compare results of both sexes with consistent study design and diagnostic criteria. This study assesses the major risk factors for coronary events in men and women from the Reykjavik Study. DESIGN: Within a prospective, population-based cohort study individuals without history of myocardial infarction were identified and the relative risk of baseline variables was assessed in relation to verified myocardial infarction or coronary death during follow-up. METHODS: Of the 9681 women and 8888 men who attended risk assessment from 1967-1991, with follow-up period of up to 28 years, 706 women and 1700 men suffered a non-fatal myocardial infarction or coronary death. RESULTS: Serum cholesterol was a significant risk factor for both sexes, with hazard ratios (HR) decreasing with age. Systolic blood pressure was a stronger risk factor for women as was ECG-confirmed left ventricular hypertrophy (women HR 2.89, 95% confidence interval [CI] 1.67-5.01; men HR 1.11 [CI 0.86-1.43]). Fasting blood glucose > or =6.7 mmol/L identified significantly higher risk for women (HR 2.65) than men (HR 2.08) as did self-reported diabetes. Triglyceride risk was significantly higher for women and decreased significantly with age. Smoking increased risk two- to five-fold, increasing with dose, for women, which was significantly higher than the doubling in risk for men. CONCLUSIONS: This large study of the major risk factors compared between the sexes demonstrates similar relative risk of myocardial infarction associated with cholesterol for both sexes, however, the relative risk is higher in women for many other risk factors such as smoking, diabetes, elevated triglycerides and left ventricular hypertrophy. |
author2 |
Heart Preventive Clinic, Icelandic Heart Association, Holtasmári 1, 201 Kópavogur, Iceland, University Hospital, Hringbraut, 101 Reykjavík, Iceland. |
format |
Article in Journal/Newspaper |
author |
Jonsdottir, Lilja S Sigfusson, Nikulas Gudnason, Vilmundur Sigvaldason, Helgi Thorgeirsson, Gudmundur |
author_facet |
Jonsdottir, Lilja S Sigfusson, Nikulas Gudnason, Vilmundur Sigvaldason, Helgi Thorgeirsson, Gudmundur |
author_sort |
Jonsdottir, Lilja S |
title |
Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. |
title_short |
Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. |
title_full |
Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. |
title_fullStr |
Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. |
title_full_unstemmed |
Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. |
title_sort |
do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? the reykjavik study. |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/32434 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00043798-200204000-00001&LSLINK=80&D=ovft J Cardiovasc Risk. 2002, 9(2):67-76 1350-6277 12006913 http://hdl.handle.net/2336/32434 Journal of cardiovascular risk |
_version_ |
1766043168367706112 |