Linkage of essential hypertension to chromosome 18q

• Main Authors: Kristjansson, Kristleifur, Manolescu, Andrei, Kristinsson, Arni, Hardarson, Thordur, Knudsen, Helga, Ingason, Sigurdur, Thorleifsson, Gudmar, Frigge, Michael L, Kong, Augustine, Gulcher, Jeffrey R, Stefansson, Kari
• Other Authors: deCODE genetics, Inc, Reykjavik, Iceland. kris@ decode.is
• Format: Article in Journal/Newspaper
• Language: English
• Published: American Heart Association 2008
• Subjects: Adult; Aged; Chromosomes; Human; Pair 18; Family Health; Female; Genetic Predisposition to Disease; Genome; Humans; Hypertension; Iceland; Linkage (Genetics); Male; Middle Aged
• Online Access: http://hdl.handle.net/2336/32052

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.