Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. The aim of the present study was to evaluate whether certain HLA antigens were risk factors for developing sarcoid arthritis and whether HLA antigens appear to account for the pheno...
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Clinical And Experimental Rheumatology S.A.S
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/317146 2023-05-15T16:49:08+02:00 Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. Petursdottir, Dyrleif Haraldsdottir, Sigridur Olina Bjarnadottir, Kristjana Jonsson, Thorbjorn Gislason, Thorarinn Gudmundsson, Sveinn Gudbjornsson, Bjorn Landspitali Univ Hosp, Ctr Rheumatol Res, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Dept Resp Med, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Iceland Blood Bank, IS-101 Reykjavik, Iceland Univ Iceland, Fac Med, Reykjavik, Iceland 2014-05-19 http://hdl.handle.net/2336/317146 en eng Clinical And Experimental Rheumatology S.A.S Clin. Exp. Rheumatol. 2013, 31 (5):711-6 0392-856X 23711303 http://hdl.handle.net/2336/317146 Clinical and experimental rheumatology Archived with thanks to Clinical and experimental rheumatology Closed - Lokað Adult Arthritis Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease HLA-A Antigens HLA-B Antigens Humans Iceland Male Middle Aged Phenotype Risk Factors Sarcoidosis Article 2014 ftlandspitaliuni 2022-05-29T08:21:56Z To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. The aim of the present study was to evaluate whether certain HLA antigens were risk factors for developing sarcoid arthritis and whether HLA antigens appear to account for the phenotype and the resolution of the arthritis condition in an unselected nationwide cohort. The Icelandic Sarcoidosis Study (ISS) contains all tissue-verified cases of sarcoidosis in Iceland since 1981. Of a total of 234 cases, 39 patients were identified with arthritis and of those 36 delivered a biosample for the study. The patient cohort has previously been described in detail. DNA was isolated from EDTA blood and HLA antigen typing was performed. A total of 544 Icelandic stem cell donors acted as controls. HLA-B8 and HLA-B14 antigens were more common among those who suffered from sarcoid arthritis (24% vs. 11%, p<0.01; 6.5% vs. 2.4%, p<0.05). DRB1*03 was also found more frequently in patients with sarcoid arthritis compared to controls (28% vs. 11%, p<0.001), while DRB1*04 was less frequently reported (5.6% vs. 17%, p<0.01). No differences were found in the HLA-A distribution between the groups. A higher proportion of patients with chronic arthritis had HLA-A11 than those with resolving joint problems (60% vs. 3.8%). Our nationwide study of patients with sarcoid arthritis further supports the conclusion that genetics may strongly influence the development and the clinical course of the disease. Furthermore, some HLA antigens may even be protective for the disease. Thus, classification of the major histocompatibility complex may have clinical implications. Icelandic Society for Rheumatology University Hospital Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Arthritis Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease HLA-A Antigens HLA-B Antigens Humans Iceland Male Middle Aged Phenotype Risk Factors Sarcoidosis |
spellingShingle |
Adult Arthritis Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease HLA-A Antigens HLA-B Antigens Humans Iceland Male Middle Aged Phenotype Risk Factors Sarcoidosis Petursdottir, Dyrleif Haraldsdottir, Sigridur Olina Bjarnadottir, Kristjana Jonsson, Thorbjorn Gislason, Thorarinn Gudmundsson, Sveinn Gudbjornsson, Bjorn Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. |
topic_facet |
Adult Arthritis Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease HLA-A Antigens HLA-B Antigens Humans Iceland Male Middle Aged Phenotype Risk Factors Sarcoidosis |
description |
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. The aim of the present study was to evaluate whether certain HLA antigens were risk factors for developing sarcoid arthritis and whether HLA antigens appear to account for the phenotype and the resolution of the arthritis condition in an unselected nationwide cohort. The Icelandic Sarcoidosis Study (ISS) contains all tissue-verified cases of sarcoidosis in Iceland since 1981. Of a total of 234 cases, 39 patients were identified with arthritis and of those 36 delivered a biosample for the study. The patient cohort has previously been described in detail. DNA was isolated from EDTA blood and HLA antigen typing was performed. A total of 544 Icelandic stem cell donors acted as controls. HLA-B8 and HLA-B14 antigens were more common among those who suffered from sarcoid arthritis (24% vs. 11%, p<0.01; 6.5% vs. 2.4%, p<0.05). DRB1*03 was also found more frequently in patients with sarcoid arthritis compared to controls (28% vs. 11%, p<0.001), while DRB1*04 was less frequently reported (5.6% vs. 17%, p<0.01). No differences were found in the HLA-A distribution between the groups. A higher proportion of patients with chronic arthritis had HLA-A11 than those with resolving joint problems (60% vs. 3.8%). Our nationwide study of patients with sarcoid arthritis further supports the conclusion that genetics may strongly influence the development and the clinical course of the disease. Furthermore, some HLA antigens may even be protective for the disease. Thus, classification of the major histocompatibility complex may have clinical implications. Icelandic Society for Rheumatology University Hospital Research Fund |
author2 |
Landspitali Univ Hosp, Ctr Rheumatol Res, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Dept Resp Med, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Iceland Blood Bank, IS-101 Reykjavik, Iceland Univ Iceland, Fac Med, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Petursdottir, Dyrleif Haraldsdottir, Sigridur Olina Bjarnadottir, Kristjana Jonsson, Thorbjorn Gislason, Thorarinn Gudmundsson, Sveinn Gudbjornsson, Bjorn |
author_facet |
Petursdottir, Dyrleif Haraldsdottir, Sigridur Olina Bjarnadottir, Kristjana Jonsson, Thorbjorn Gislason, Thorarinn Gudmundsson, Sveinn Gudbjornsson, Bjorn |
author_sort |
Petursdottir, Dyrleif |
title |
Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. |
title_short |
Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. |
title_full |
Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. |
title_fullStr |
Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. |
title_full_unstemmed |
Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. |
title_sort |
sarcoid arthropathy and the association with the human leukocyte antigen. the icelandic sarcoidosis study. |
publisher |
Clinical And Experimental Rheumatology S.A.S |
publishDate |
2014 |
url |
http://hdl.handle.net/2336/317146 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Clin. Exp. Rheumatol. 2013, 31 (5):711-6 0392-856X 23711303 http://hdl.handle.net/2336/317146 Clinical and experimental rheumatology |
op_rights |
Archived with thanks to Clinical and experimental rheumatology Closed - Lokað |
_version_ |
1766039213624524800 |