Intra-individual change over time in DNA methylation with familial clustering.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field CONTEXT: Changes over time in epigenetic marks, which are modifications of DNA such as by DNA methylation, may help explain the late onset of common human diseases. However, changes in meth...
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Online Access: | http://hdl.handle.net/2336/31572 https://doi.org/10.1001/jama.299.24.2877 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/31572 2023-05-15T16:51:28+02:00 Intra-individual change over time in DNA methylation with familial clustering. Bjornsson, Hans T Sigurdsson, Martin I Fallin, M Daniele Irizarry, Rafael A Aspelund, Thor Cui, Hengmi Yu, Wenqiang Rongione, Michael A Ekström, Tomas J Harris, Tamara B Launer, Lenore J Eiriksdottir, Gudny Leppert, Mark F Sapienza, Carmen Gudnason, Vilmundur Feinberg, Andrew P Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. 2008-07-10 http://hdl.handle.net/2336/31572 https://doi.org/10.1001/jama.299.24.2877 en eng American Medical Association http://jama.ama-assn.org/cgi/content/abstract/299/24/2877 JAMA. 2008, 299(24):2877-83 0098-7484 18577732 doi:10.1001/jama.299.24.2877 http://hdl.handle.net/2336/31572 1538-3598 JAMA : the journal of the American Medical Association Aged 80 and over DNA Methylation Epigenesis Genetic Female Humans Iceland Longitudinal Studies Luminescent Measurements Male Pedigree Time Factors Utah Article 2008 ftlandspitaliuni https://doi.org/10.1001/jama.299.24.2877 2022-05-29T08:21:10Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field CONTEXT: Changes over time in epigenetic marks, which are modifications of DNA such as by DNA methylation, may help explain the late onset of common human diseases. However, changes in methylation or other epigenetic marks over time in a given individual have not yet been investigated. OBJECTIVES: To determine whether there are longitudinal changes in global DNA methylation in individuals and to evaluate whether methylation maintenance demonstrates familial clustering. DESIGN, SETTING, AND PARTICIPANTS: We measured global DNA methylation by luminometric methylation assay, a quantitative measurement of genome-wide DNA methylation, on DNA sampled at 2 visits on average 11 years apart in 111 individuals from an Icelandic cohort (1991 and 2002-2005) and on average 16 years apart in 126 individuals from a Utah sample (1982-1985 and 1997-2005). MAIN OUTCOME MEASURE: Global methylation changes over time. RESULTS: Twenty-nine percent of Icelandic individuals showed greater than 10% methylation change over time (P < .001). The family-based Utah sample also showed intra-individual changes over time, and further demonstrated familial clustering of methylation change (P = .003). The family showing the greatest global methylation loss also demonstrated the greatest loss of gene-specific methylation by a separate methylation assay. CONCLUSION: These data indicate that methylation changes over time and suggest that methylation maintenance may be under genetic control. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive JAMA 299 24 2877 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over DNA Methylation Epigenesis Genetic Female Humans Iceland Longitudinal Studies Luminescent Measurements Male Pedigree Time Factors Utah |
spellingShingle |
Aged 80 and over DNA Methylation Epigenesis Genetic Female Humans Iceland Longitudinal Studies Luminescent Measurements Male Pedigree Time Factors Utah Bjornsson, Hans T Sigurdsson, Martin I Fallin, M Daniele Irizarry, Rafael A Aspelund, Thor Cui, Hengmi Yu, Wenqiang Rongione, Michael A Ekström, Tomas J Harris, Tamara B Launer, Lenore J Eiriksdottir, Gudny Leppert, Mark F Sapienza, Carmen Gudnason, Vilmundur Feinberg, Andrew P Intra-individual change over time in DNA methylation with familial clustering. |
topic_facet |
Aged 80 and over DNA Methylation Epigenesis Genetic Female Humans Iceland Longitudinal Studies Luminescent Measurements Male Pedigree Time Factors Utah |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field CONTEXT: Changes over time in epigenetic marks, which are modifications of DNA such as by DNA methylation, may help explain the late onset of common human diseases. However, changes in methylation or other epigenetic marks over time in a given individual have not yet been investigated. OBJECTIVES: To determine whether there are longitudinal changes in global DNA methylation in individuals and to evaluate whether methylation maintenance demonstrates familial clustering. DESIGN, SETTING, AND PARTICIPANTS: We measured global DNA methylation by luminometric methylation assay, a quantitative measurement of genome-wide DNA methylation, on DNA sampled at 2 visits on average 11 years apart in 111 individuals from an Icelandic cohort (1991 and 2002-2005) and on average 16 years apart in 126 individuals from a Utah sample (1982-1985 and 1997-2005). MAIN OUTCOME MEASURE: Global methylation changes over time. RESULTS: Twenty-nine percent of Icelandic individuals showed greater than 10% methylation change over time (P < .001). The family-based Utah sample also showed intra-individual changes over time, and further demonstrated familial clustering of methylation change (P = .003). The family showing the greatest global methylation loss also demonstrated the greatest loss of gene-specific methylation by a separate methylation assay. CONCLUSION: These data indicate that methylation changes over time and suggest that methylation maintenance may be under genetic control. |
author2 |
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. |
format |
Article in Journal/Newspaper |
author |
Bjornsson, Hans T Sigurdsson, Martin I Fallin, M Daniele Irizarry, Rafael A Aspelund, Thor Cui, Hengmi Yu, Wenqiang Rongione, Michael A Ekström, Tomas J Harris, Tamara B Launer, Lenore J Eiriksdottir, Gudny Leppert, Mark F Sapienza, Carmen Gudnason, Vilmundur Feinberg, Andrew P |
author_facet |
Bjornsson, Hans T Sigurdsson, Martin I Fallin, M Daniele Irizarry, Rafael A Aspelund, Thor Cui, Hengmi Yu, Wenqiang Rongione, Michael A Ekström, Tomas J Harris, Tamara B Launer, Lenore J Eiriksdottir, Gudny Leppert, Mark F Sapienza, Carmen Gudnason, Vilmundur Feinberg, Andrew P |
author_sort |
Bjornsson, Hans T |
title |
Intra-individual change over time in DNA methylation with familial clustering. |
title_short |
Intra-individual change over time in DNA methylation with familial clustering. |
title_full |
Intra-individual change over time in DNA methylation with familial clustering. |
title_fullStr |
Intra-individual change over time in DNA methylation with familial clustering. |
title_full_unstemmed |
Intra-individual change over time in DNA methylation with familial clustering. |
title_sort |
intra-individual change over time in dna methylation with familial clustering. |
publisher |
American Medical Association |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/31572 https://doi.org/10.1001/jama.299.24.2877 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://jama.ama-assn.org/cgi/content/abstract/299/24/2877 JAMA. 2008, 299(24):2877-83 0098-7484 18577732 doi:10.1001/jama.299.24.2877 http://hdl.handle.net/2336/31572 1538-3598 JAMA : the journal of the American Medical Association |
op_doi |
https://doi.org/10.1001/jama.299.24.2877 |
container_title |
JAMA |
container_volume |
299 |
container_issue |
24 |
container_start_page |
2877 |
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1766041574442008576 |