The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study.

• Published in: International Journal of Obesity
• Main Authors: Arnardottir, E S, Maislin, G, Jackson, N, Schwab, R J, Benediktsdottir, B, Teff, K, Juliusson, S, Pack, A I, Gislason, T
• Other Authors: Landspitali Natl Univ Hosp Iceland, Dept Resp Med & Sleep, Reykjavik, Iceland, Univ Iceland, Fac Med, Reykjavik, Iceland, Univ Penn, Perelman Sch Med, Ctr Sleep & Circadian Neurobiol, Div Sleep Med,Dept Med, Philadelphia, PA 19104 USA, Monell Chem Senses Ctr, Philadelphia, PA 19104 USA, Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA, Landspitali Natl Univ Hosp Iceland, Dept Otolaryngol, Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2013
• Subjects: Offita; Kæfisvefn; Háþrýstingur; Líkamsþyngdarstuðull; Adult; Biological Markers; Body Composition; Body Mass Index; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hypertension; Iceland; Intra-Abdominal Fat; Leptin; Male; Middle Aged; Obesity; Polysomnography; Questionnaires; Severity of Illness Index; Sex Distribution; Sleep Apnea Syndromes; Subcutaneous Fat; Time Factors
• Online Access: http://hdl.handle.net/2336/314186; https://doi.org/10.1038/ijo.2012.138

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. To assess whether sleep apnea severity has an independent relationship with leptin levels in blood after adjusting for different measures of obesity and whether the relationship between obstructive sleep apnea (OSA) severity and leptin levels differs depending on obesity level. Cross-sectional study of 452 untreated OSA patients (377 males and 75 females), in the Icelandic Sleep Apnea Cohort (ISAC), age 54.3±10.6 (mean±s.d.), body mass index (BMI) 32.7±5.3 kg m(-2) and apnea-hypopnea index 40.2±16.1 events per h. A sleep study and magnetic resonance imaging of abdominal visceral and subcutaneous fat volume were performed, as well as fasting serum morning leptin levels were measured. Leptin levels were more highly correlated with BMI, total abdominal and subcutaneous fat volume than visceral fat volume per se. No relationship was found between sleep apnea severity and leptin levels, assessed within three BMI groups (BMI <30, BMI 30-35 and BMI > or =35 kg m(-2)). In a multiple linear regression model, adjusted for gender, BMI explained 38.7% of the variance in leptin levels, gender explained 21.2% but OSA severity did not have a significant role and no interaction was found between OSA severity and BMI on leptin levels. However, hypertension had a significant effect on the interaction between OSA severity and obesity (P=0.04). In post-hoc analysis for nonhypertensive OSA subjects (n=249), the association between leptin levels and OSA severity explained a minor but significant variance (3.2%) in leptin levels. This relationship was greatest for nonobese nonhypertensive subjects (significant interaction with obesity level). No relationship of OSA severity and leptin levels was found for hypertensive subjects (n=199). Obesity and gender are the dominant determinants of leptin levels. OSA severity is not related to leptin levels except to a minor degree in nonhypertensive nonobese OSA ...