Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. The authors aimed to investigate the incidence and outcomes of acute upper gastrointestinal bleeding (AUGIB) and to examine the role of drugs potentially associated with AUGIB. The...
Published in: | Scandinavian Journal of Gastroenterology |
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Online Access: | http://hdl.handle.net/2336/313331 https://doi.org/10.3109/00365521.2012.763174 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/313331 2023-05-15T16:46:57+02:00 Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. Hreinsson, Jóhann P Kalaitzakis, Evangelos Gudmundsson, Sveinn Björnsson, Einar S Natl Univ Hosp Iceland, Dept Internal Med, Sect Gastroenterol & Hepatol, IS-101 Reykjavik, Iceland, Hosp, Dept Gastroenterol, Lund, Sweden, Blood Bank, Natl Univ Hosp, Reykjavik, Iceland 2013 http://hdl.handle.net/2336/313331 https://doi.org/10.3109/00365521.2012.763174 en eng Informa Healthcare http://dx.doi.org/10.3109/00365521.2012.763174 Scand. J. Gastroenterol. 2013, 48 (4):439-47 1502-7708 23356751 doi:10.3109/00365521.2012.763174 http://hdl.handle.net/2336/313331 Scandinavian journal of gastroenterology Archived with thanks to Scandinavian journal of gastroenterology Landspitali Access - LSH-aðgangur Meltingarfærasjúkdómar Aged 80 and over Anti-Inflammatory Agents Non-Steroidal Anticoagulants Female Gastrointestinal Hemorrhage Hematemesis Humans Iceland Incidence Male Melena Middle Aged Prospective Studies Risk Factors Severity of Illness Index Upper Gastrointestinal Tract Warfarin Article 2013 ftlandspitaliuni https://doi.org/10.3109/00365521.2012.763174 2022-05-29T08:21:55Z To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. The authors aimed to investigate the incidence and outcomes of acute upper gastrointestinal bleeding (AUGIB) and to examine the role of drugs potentially associated with AUGIB. The study was prospective, population-based and consisted of all patients who underwent upper gastrointestinal endoscopy (UGE), during the year of 2010 at the National University Hospital of Iceland. Drug intake of NSAIDs, low-dose aspirin (LDA), warfarin, SSRIs and bisphosphonates prior to GIB was prospectively registered and also checked in a Pharmaceutical Database covering all prescriptions in Iceland. An age- and gender-matched control group consisted of patients who underwent UGE during the study period and were without GIB. A total of 1731 patients underwent 2058 UGEs. Overall, 156 patients had AUGIB. The crude incidence for AUGIB was 87/100,000 inhabitants per year. The most common etiologies were duodenal (21%) and gastric ulcers (15%). Use of LDA (40% vs. 30%), NSAIDs (20% vs. 8%), warfarin (15% vs. 7%), combination of NSAIDs + LDA (8% vs. 1%) and SSRIs + LDA (8% vs. 3%) were significantly more common among bleeders than non-bleeders. Three patients (1.9%) had emergency surgery and two patients died of AUGIB. Independent predictors of clinically significant bleeding were gastric ulcer (OR 6.6, p = 0.012) and NSAIDs (OR 6.6, p = 0.004). LDA, NSAIDs and warfarin play an important role in AUGIB etiology and particularly combinations of drugs. Gastric ulcer and NSAIDs were independent predictors of severe bleeding. Mortality and the need for surgery during hospitalization was low in this population-based setting. National University Hospital of Iceland Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Gastroenterology 48 4 439 447 |
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Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Meltingarfærasjúkdómar Aged 80 and over Anti-Inflammatory Agents Non-Steroidal Anticoagulants Female Gastrointestinal Hemorrhage Hematemesis Humans Iceland Incidence Male Melena Middle Aged Prospective Studies Risk Factors Severity of Illness Index Upper Gastrointestinal Tract Warfarin |
spellingShingle |
Meltingarfærasjúkdómar Aged 80 and over Anti-Inflammatory Agents Non-Steroidal Anticoagulants Female Gastrointestinal Hemorrhage Hematemesis Humans Iceland Incidence Male Melena Middle Aged Prospective Studies Risk Factors Severity of Illness Index Upper Gastrointestinal Tract Warfarin Hreinsson, Jóhann P Kalaitzakis, Evangelos Gudmundsson, Sveinn Björnsson, Einar S Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
topic_facet |
Meltingarfærasjúkdómar Aged 80 and over Anti-Inflammatory Agents Non-Steroidal Anticoagulants Female Gastrointestinal Hemorrhage Hematemesis Humans Iceland Incidence Male Melena Middle Aged Prospective Studies Risk Factors Severity of Illness Index Upper Gastrointestinal Tract Warfarin |
description |
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. The authors aimed to investigate the incidence and outcomes of acute upper gastrointestinal bleeding (AUGIB) and to examine the role of drugs potentially associated with AUGIB. The study was prospective, population-based and consisted of all patients who underwent upper gastrointestinal endoscopy (UGE), during the year of 2010 at the National University Hospital of Iceland. Drug intake of NSAIDs, low-dose aspirin (LDA), warfarin, SSRIs and bisphosphonates prior to GIB was prospectively registered and also checked in a Pharmaceutical Database covering all prescriptions in Iceland. An age- and gender-matched control group consisted of patients who underwent UGE during the study period and were without GIB. A total of 1731 patients underwent 2058 UGEs. Overall, 156 patients had AUGIB. The crude incidence for AUGIB was 87/100,000 inhabitants per year. The most common etiologies were duodenal (21%) and gastric ulcers (15%). Use of LDA (40% vs. 30%), NSAIDs (20% vs. 8%), warfarin (15% vs. 7%), combination of NSAIDs + LDA (8% vs. 1%) and SSRIs + LDA (8% vs. 3%) were significantly more common among bleeders than non-bleeders. Three patients (1.9%) had emergency surgery and two patients died of AUGIB. Independent predictors of clinically significant bleeding were gastric ulcer (OR 6.6, p = 0.012) and NSAIDs (OR 6.6, p = 0.004). LDA, NSAIDs and warfarin play an important role in AUGIB etiology and particularly combinations of drugs. Gastric ulcer and NSAIDs were independent predictors of severe bleeding. Mortality and the need for surgery during hospitalization was low in this population-based setting. National University Hospital of Iceland Research Fund |
author2 |
Natl Univ Hosp Iceland, Dept Internal Med, Sect Gastroenterol & Hepatol, IS-101 Reykjavik, Iceland, Hosp, Dept Gastroenterol, Lund, Sweden, Blood Bank, Natl Univ Hosp, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Hreinsson, Jóhann P Kalaitzakis, Evangelos Gudmundsson, Sveinn Björnsson, Einar S |
author_facet |
Hreinsson, Jóhann P Kalaitzakis, Evangelos Gudmundsson, Sveinn Björnsson, Einar S |
author_sort |
Hreinsson, Jóhann P |
title |
Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
title_short |
Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
title_full |
Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
title_fullStr |
Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
title_full_unstemmed |
Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
title_sort |
upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. |
publisher |
Informa Healthcare |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/313331 https://doi.org/10.3109/00365521.2012.763174 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.3109/00365521.2012.763174 Scand. J. Gastroenterol. 2013, 48 (4):439-47 1502-7708 23356751 doi:10.3109/00365521.2012.763174 http://hdl.handle.net/2336/313331 Scandinavian journal of gastroenterology |
op_rights |
Archived with thanks to Scandinavian journal of gastroenterology Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.3109/00365521.2012.763174 |
container_title |
Scandinavian Journal of Gastroenterology |
container_volume |
48 |
container_issue |
4 |
container_start_page |
439 |
op_container_end_page |
447 |
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1766037042353930240 |