CRP is associated with lung function decline in men but not women: a prospective study.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairm...
Published in: | Respiratory Medicine |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Elsevier Science
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Online Access: | http://hdl.handle.net/2336/313306 https://doi.org/10.1016/j.rmed.2012.09.020 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/313306 2023-05-15T18:07:01+02:00 CRP is associated with lung function decline in men but not women: a prospective study. Ólafsdóttir, Inga Sif Gíslason, Thórarinn Gudnason, Vilmundur Benediktsdóttir, Bryndís Ólafsson, Ísleifur Aspelund, Thor Thjódleifsson, Bjarni Janson, Christer Uppsala Univ, Univ Hosp, Dept Med Sci, S-75185 Uppsala, Sweden Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, IS-108 Reykjavik, Iceland Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland Iceland Heart Assoc, IS-201 Kopavogur, Iceland Landspitali Univ Hosp, Dept Clin Biochem, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Dept Gastroenterol, IS-101 Reykjavik, Iceland 2013-02-24 http://hdl.handle.net/2336/313306 https://doi.org/10.1016/j.rmed.2012.09.020 en eng Elsevier Science http//:dx.doi.org/10.1016/j.rmed.2012.09.020 http://www.sciencedirect.com/science/article/pii/S0954611112003617 Respir Med 2013, 107(1):91-7 1532-3064 23083841 doi:10.1016/j.rmed.2012.09.020 http://hdl.handle.net/2336/313306 Respiratory medicine Archived with thanks to Respiratory medicine National Consortium - Landsaðgangur Adult Aging Biological Markers C-Reactive Protein Female Follow-Up Studies Forced Expiratory Volume Humans Inflammation Lung Male Middle Aged Patient Dropouts Prospective Studies Sex Characteristics Smoking Vital Capacity Young Adult Article 2013 ftlandspitaliuni https://doi.org/10.1016/j.rmed.2012.09.020 2022-05-29T08:21:55Z To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairment in men than women. The aim was to evaluate gender differences in the longitudinal association between systemic inflammation and lung function. We used data from randomly chosen residents of Reykjavík, born 1940-54, who were investigated in three stages: Baseline (1973-75; 1983-85) and follow-up (2001-03). The participants (n = 1049, 574 women) had a mean age of 28 ± 6 years at baseline and mean follow-up time of 27 ± 4 years. At each stage lung function (FEV(1) and FVC) and C-reactive protein (CRP) were evaluated. Change in FEV(1) (p = 0.04) and FVC (p = 0.01) was associated with baseline CRP in men but not in women. In the multiple variable analysis, CRP at baseline was associated with a decline in FEV(1) (-3.1 mL/year, 95% CI: -5.1, -0.99) and FVC (-2.5 mL/year, 95% CI: -4.4, -0.65) in men but not in women. Similarly during follow-up, change in CRP, standardised to 1SD, was associated with a decline in FEV(1) (-0.19 mL/year, 95% CI: -0.30, -0.07) and FVC (-0.11 mL/year, 95% CI: -0.22, -0.01)) in men but not in women. This prospective study confirms a stronger association between systemic inflammation and lung function decline in men than in women. This may indicate a gender difference in the mechanisms of lung function decline. Icelandic Research Council 050405011 Landspitali-University Hospital Research Fund Article in Journal/Newspaper Reykjavík Reykjavík Hirsla - Landspítali University Hospital research archive Reykjavík Respiratory Medicine 107 1 91 97 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Aging Biological Markers C-Reactive Protein Female Follow-Up Studies Forced Expiratory Volume Humans Inflammation Lung Male Middle Aged Patient Dropouts Prospective Studies Sex Characteristics Smoking Vital Capacity Young Adult |
spellingShingle |
Adult Aging Biological Markers C-Reactive Protein Female Follow-Up Studies Forced Expiratory Volume Humans Inflammation Lung Male Middle Aged Patient Dropouts Prospective Studies Sex Characteristics Smoking Vital Capacity Young Adult Ólafsdóttir, Inga Sif Gíslason, Thórarinn Gudnason, Vilmundur Benediktsdóttir, Bryndís Ólafsson, Ísleifur Aspelund, Thor Thjódleifsson, Bjarni Janson, Christer CRP is associated with lung function decline in men but not women: a prospective study. |
topic_facet |
Adult Aging Biological Markers C-Reactive Protein Female Follow-Up Studies Forced Expiratory Volume Humans Inflammation Lung Male Middle Aged Patient Dropouts Prospective Studies Sex Characteristics Smoking Vital Capacity Young Adult |
description |
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairment in men than women. The aim was to evaluate gender differences in the longitudinal association between systemic inflammation and lung function. We used data from randomly chosen residents of Reykjavík, born 1940-54, who were investigated in three stages: Baseline (1973-75; 1983-85) and follow-up (2001-03). The participants (n = 1049, 574 women) had a mean age of 28 ± 6 years at baseline and mean follow-up time of 27 ± 4 years. At each stage lung function (FEV(1) and FVC) and C-reactive protein (CRP) were evaluated. Change in FEV(1) (p = 0.04) and FVC (p = 0.01) was associated with baseline CRP in men but not in women. In the multiple variable analysis, CRP at baseline was associated with a decline in FEV(1) (-3.1 mL/year, 95% CI: -5.1, -0.99) and FVC (-2.5 mL/year, 95% CI: -4.4, -0.65) in men but not in women. Similarly during follow-up, change in CRP, standardised to 1SD, was associated with a decline in FEV(1) (-0.19 mL/year, 95% CI: -0.30, -0.07) and FVC (-0.11 mL/year, 95% CI: -0.22, -0.01)) in men but not in women. This prospective study confirms a stronger association between systemic inflammation and lung function decline in men than in women. This may indicate a gender difference in the mechanisms of lung function decline. Icelandic Research Council 050405011 Landspitali-University Hospital Research Fund |
author2 |
Uppsala Univ, Univ Hosp, Dept Med Sci, S-75185 Uppsala, Sweden Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, IS-108 Reykjavik, Iceland Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland Iceland Heart Assoc, IS-201 Kopavogur, Iceland Landspitali Univ Hosp, Dept Clin Biochem, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Dept Gastroenterol, IS-101 Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Ólafsdóttir, Inga Sif Gíslason, Thórarinn Gudnason, Vilmundur Benediktsdóttir, Bryndís Ólafsson, Ísleifur Aspelund, Thor Thjódleifsson, Bjarni Janson, Christer |
author_facet |
Ólafsdóttir, Inga Sif Gíslason, Thórarinn Gudnason, Vilmundur Benediktsdóttir, Bryndís Ólafsson, Ísleifur Aspelund, Thor Thjódleifsson, Bjarni Janson, Christer |
author_sort |
Ólafsdóttir, Inga Sif |
title |
CRP is associated with lung function decline in men but not women: a prospective study. |
title_short |
CRP is associated with lung function decline in men but not women: a prospective study. |
title_full |
CRP is associated with lung function decline in men but not women: a prospective study. |
title_fullStr |
CRP is associated with lung function decline in men but not women: a prospective study. |
title_full_unstemmed |
CRP is associated with lung function decline in men but not women: a prospective study. |
title_sort |
crp is associated with lung function decline in men but not women: a prospective study. |
publisher |
Elsevier Science |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/313306 https://doi.org/10.1016/j.rmed.2012.09.020 |
geographic |
Reykjavík |
geographic_facet |
Reykjavík |
genre |
Reykjavík Reykjavík |
genre_facet |
Reykjavík Reykjavík |
op_relation |
http//:dx.doi.org/10.1016/j.rmed.2012.09.020 http://www.sciencedirect.com/science/article/pii/S0954611112003617 Respir Med 2013, 107(1):91-7 1532-3064 23083841 doi:10.1016/j.rmed.2012.09.020 http://hdl.handle.net/2336/313306 Respiratory medicine |
op_rights |
Archived with thanks to Respiratory medicine National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1016/j.rmed.2012.09.020 |
container_title |
Respiratory Medicine |
container_volume |
107 |
container_issue |
1 |
container_start_page |
91 |
op_container_end_page |
97 |
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1766178858077257728 |