CRP is associated with lung function decline in men but not women: a prospective study.

• Published in: Respiratory Medicine
• Main Authors: Ólafsdóttir, Inga Sif, Gíslason, Thórarinn, Gudnason, Vilmundur, Benediktsdóttir, Bryndís, Ólafsson, Ísleifur, Aspelund, Thor, Thjódleifsson, Bjarni, Janson, Christer
• Other Authors: Uppsala Univ, Univ Hosp, Dept Med Sci, S-75185 Uppsala, Sweden Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, IS-108 Reykjavik, Iceland Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland Iceland Heart Assoc, IS-201 Kopavogur, Iceland Landspitali Univ Hosp, Dept Clin Biochem, IS-101 Reykjavik, Iceland Landspitali Univ Hosp, Dept Gastroenterol, IS-101 Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier Science 2013
• Subjects: Adult; Aging; Biological Markers; C-Reactive Protein; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Inflammation; Lung; Male; Middle Aged; Patient Dropouts; Prospective Studies; Sex Characteristics; Smoking; Vital Capacity; Young Adult; Reykjavík
• Online Access: http://hdl.handle.net/2336/313306; https://doi.org/10.1016/j.rmed.2012.09.020

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairment in men than women. The aim was to evaluate gender differences in the longitudinal association between systemic inflammation and lung function. We used data from randomly chosen residents of Reykjavík, born 1940-54, who were investigated in three stages: Baseline (1973-75; 1983-85) and follow-up (2001-03). The participants (n = 1049, 574 women) had a mean age of 28 ± 6 years at baseline and mean follow-up time of 27 ± 4 years. At each stage lung function (FEV(1) and FVC) and C-reactive protein (CRP) were evaluated. Change in FEV(1) (p = 0.04) and FVC (p = 0.01) was associated with baseline CRP in men but not in women. In the multiple variable analysis, CRP at baseline was associated with a decline in FEV(1) (-3.1 mL/year, 95% CI: -5.1, -0.99) and FVC (-2.5 mL/year, 95% CI: -4.4, -0.65) in men but not in women. Similarly during follow-up, change in CRP, standardised to 1SD, was associated with a decline in FEV(1) (-0.19 mL/year, 95% CI: -0.30, -0.07) and FVC (-0.11 mL/year, 95% CI: -0.22, -0.01)) in men but not in women. This prospective study confirms a stronger association between systemic inflammation and lung function decline in men than in women. This may indicate a gender difference in the mechanisms of lung function decline. Icelandic Research Council 050405011 Landspitali-University Hospital Research Fund