Choroidal oximetry with a noninvasive spectrophotometric oximeter.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. PURPOSE: The purpose of the study was to establish a new technology to measure hemoglobin oxygen saturation in human choroidal vasculature with a noninvasive spectrophotometric oxim...
Published in: | Investigative Opthalmology & Visual Science |
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Association For Research In Vision And Ophthalmology (Arvo)
2013
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Online Access: | http://hdl.handle.net/2336/312612 https://doi.org/10.1167/iovs.12-10507 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/312612 2023-05-15T16:51:49+02:00 Choroidal oximetry with a noninvasive spectrophotometric oximeter. Kristjansdottir, Jona Valgerdur Hardarson, Sveinn Hakon Harvey, Andrew R Olafsdottir, Olof Birna Eliasdottir, Thorunn Scheving Stefánsson, Einar Landspitali Univ Hosp, Dept Ophthalmol, Reykjavik, Iceland 2013-05 http://hdl.handle.net/2336/312612 https://doi.org/10.1167/iovs.12-10507 en eng Association For Research In Vision And Ophthalmology (Arvo) http://dx.doi.org/10.1167/iovs.12-10507 http://www.iovs.org/content/54/5/3234.full.pdf+html Invest. Ophthalmol. Vis. Sci. 2013, 54(5):3234-9 1552-5783 23572109 doi:10.1167/iovs.12-10507 http://hdl.handle.net/2336/312612 Investigative ophthalmology & visual science Archived with thanks to Investigative ophthalmology & visual science Adult Arterioles Choroid Female Humans Hyperoxia Male Oximetry Oxygen Oxygen Consumption Oxyhemoglobins Retinal Artery Retinal Vein Spectrophotometry Venules Article 2013 ftlandspitaliuni https://doi.org/10.1167/iovs.12-10507 2022-05-29T08:21:55Z To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. PURPOSE: The purpose of the study was to establish a new technology to measure hemoglobin oxygen saturation in human choroidal vasculature with a noninvasive spectrophotometric oximeter. METHODS: The fundus camera-based oximeter captures dual-wavelength oximetry images of the fundus and calculates optical density ratio (ODR), which is inversely related to hemoglobin oxygen saturation. Sixteen healthy and lightly pigmented individuals were imaged during normoxia and six during both normoxia and pure oxygen breathing (hyperoxia). ODR was measured for choroidal vessels, vortex veins, and retinal arterioles and venules. RESULTS: ODR was 0.10 ± 0.10 (mean ± SD) for choroidal vessels, 0.13 ± 0.12 for vortex veins, 0.22 ± 0.04 for retinal arterioles, and 0.50 ± 0.09 for retinal venules. Inhalation of pure oxygen lowered ODR levels in all vessel types; the decrease was 0.035 ± 0.028 in choroidal vessels (P = 0.029, paired t-test), 0.022 ± 0.017 in the retinal arterioles (P = 0.022, paired t-test), and 0.246 ± 0.067 in retinal venules (P = 0.0003, paired t-test). CONCLUSIONS: The ODR can be measured noninvasively in the choroidal vessels of lightly pigmented individuals and is significantly lower in choroidal vessels than in retinal arterioles. This may suggest higher oxygen saturation but is also compatible with the reduced contrast of choroidal vessels at both wavelengths that is expected from scattering of light within the choroid. The decrease of ODR during hyperoxia was significant for all vessel types, which confirms that the oximeter is sensitive to changes in oxygen saturation in both choroidal and retinal vessels. Prevention of Blindness Fund Landspitali-University Hospital Research Fund University of Iceland Research Fund Icelandic Center for Research (Rannis) Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Investigative Opthalmology & Visual Science 54 5 3234 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Arterioles Choroid Female Humans Hyperoxia Male Oximetry Oxygen Oxygen Consumption Oxyhemoglobins Retinal Artery Retinal Vein Spectrophotometry Venules |
spellingShingle |
Adult Arterioles Choroid Female Humans Hyperoxia Male Oximetry Oxygen Oxygen Consumption Oxyhemoglobins Retinal Artery Retinal Vein Spectrophotometry Venules Kristjansdottir, Jona Valgerdur Hardarson, Sveinn Hakon Harvey, Andrew R Olafsdottir, Olof Birna Eliasdottir, Thorunn Scheving Stefánsson, Einar Choroidal oximetry with a noninvasive spectrophotometric oximeter. |
topic_facet |
Adult Arterioles Choroid Female Humans Hyperoxia Male Oximetry Oxygen Oxygen Consumption Oxyhemoglobins Retinal Artery Retinal Vein Spectrophotometry Venules |
description |
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. PURPOSE: The purpose of the study was to establish a new technology to measure hemoglobin oxygen saturation in human choroidal vasculature with a noninvasive spectrophotometric oximeter. METHODS: The fundus camera-based oximeter captures dual-wavelength oximetry images of the fundus and calculates optical density ratio (ODR), which is inversely related to hemoglobin oxygen saturation. Sixteen healthy and lightly pigmented individuals were imaged during normoxia and six during both normoxia and pure oxygen breathing (hyperoxia). ODR was measured for choroidal vessels, vortex veins, and retinal arterioles and venules. RESULTS: ODR was 0.10 ± 0.10 (mean ± SD) for choroidal vessels, 0.13 ± 0.12 for vortex veins, 0.22 ± 0.04 for retinal arterioles, and 0.50 ± 0.09 for retinal venules. Inhalation of pure oxygen lowered ODR levels in all vessel types; the decrease was 0.035 ± 0.028 in choroidal vessels (P = 0.029, paired t-test), 0.022 ± 0.017 in the retinal arterioles (P = 0.022, paired t-test), and 0.246 ± 0.067 in retinal venules (P = 0.0003, paired t-test). CONCLUSIONS: The ODR can be measured noninvasively in the choroidal vessels of lightly pigmented individuals and is significantly lower in choroidal vessels than in retinal arterioles. This may suggest higher oxygen saturation but is also compatible with the reduced contrast of choroidal vessels at both wavelengths that is expected from scattering of light within the choroid. The decrease of ODR during hyperoxia was significant for all vessel types, which confirms that the oximeter is sensitive to changes in oxygen saturation in both choroidal and retinal vessels. Prevention of Blindness Fund Landspitali-University Hospital Research Fund University of Iceland Research Fund Icelandic Center for Research (Rannis) |
author2 |
Landspitali Univ Hosp, Dept Ophthalmol, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Kristjansdottir, Jona Valgerdur Hardarson, Sveinn Hakon Harvey, Andrew R Olafsdottir, Olof Birna Eliasdottir, Thorunn Scheving Stefánsson, Einar |
author_facet |
Kristjansdottir, Jona Valgerdur Hardarson, Sveinn Hakon Harvey, Andrew R Olafsdottir, Olof Birna Eliasdottir, Thorunn Scheving Stefánsson, Einar |
author_sort |
Kristjansdottir, Jona Valgerdur |
title |
Choroidal oximetry with a noninvasive spectrophotometric oximeter. |
title_short |
Choroidal oximetry with a noninvasive spectrophotometric oximeter. |
title_full |
Choroidal oximetry with a noninvasive spectrophotometric oximeter. |
title_fullStr |
Choroidal oximetry with a noninvasive spectrophotometric oximeter. |
title_full_unstemmed |
Choroidal oximetry with a noninvasive spectrophotometric oximeter. |
title_sort |
choroidal oximetry with a noninvasive spectrophotometric oximeter. |
publisher |
Association For Research In Vision And Ophthalmology (Arvo) |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/312612 https://doi.org/10.1167/iovs.12-10507 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1167/iovs.12-10507 http://www.iovs.org/content/54/5/3234.full.pdf+html Invest. Ophthalmol. Vis. Sci. 2013, 54(5):3234-9 1552-5783 23572109 doi:10.1167/iovs.12-10507 http://hdl.handle.net/2336/312612 Investigative ophthalmology & visual science |
op_rights |
Archived with thanks to Investigative ophthalmology & visual science |
op_doi |
https://doi.org/10.1167/iovs.12-10507 |
container_title |
Investigative Opthalmology & Visual Science |
container_volume |
54 |
container_issue |
5 |
container_start_page |
3234 |
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1766041925042831360 |