Association of HLA-DRB1*01 with Dupuytren's disease.

• Published in: Scandinavian Journal of Rheumatology
• Main Authors: Jónsson, T, Gudmundsson, K G, Bjarnadóttir, K, Hjálmarsdótti, I B, Gudmundsson, S, Arngrímsson, R
• Other Authors: Landspitali University Hospital, Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Informa Healthcare 2013
• Subjects: Aged; 80 and over; Cohort Studies; Dupuytren Contracture; European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains; Health Surveys; Humans; Iceland; Male; Sex Distribution
• Online Access: http://hdl.handle.net/2336/312374; https://doi.org/10.3109/03009742.2012.713982

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. OBJECTIVES: To explore the human leucocyte antigen (HLA)-DRB1 allele frequency in Dupuytren's disease (DD). METHOD: HLA-DRB1 genotypes were analysed by sequence-specific primers (SSPs) in samples collected from 172 men participating in a nested case-control study on the clinical manifestations and progression of DD. Of those, 121 had signs of DD while 51 did not. Of the 121 men with DD, 49 had contracted fingers or had been operated on, while 72 had nodules or fibrous cords in the palms. Odds ratios (ORs) and 95% confidence interval (CIs) were used to evaluate the results. RESULTS: The HLA-DRB1*01 allele was observed in 26 of the 121 affected men (23.7%) but in only four of the controls (7.8%) (OR 3.22, 95% CI 1.06-9.75). The HLA-DRB1*01 allele frequency in those affected was 11%, while in the control group it was 4% (OR 3.07, 95% CI 1.05-9.03). CONCLUSIONS: This observation indicates a possible association of HLA-DRB1*01 with DD, but further studies are needed for confirmation. Icelandic Heart Association