Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The results of epidemiologic studies have linked birth size to adult glucose intolerance. OBJECTIVE: We investigated this association in a genetically homogeneous population wit...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/30476 2023-05-15T16:49:08+02:00 Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population Birgisdottir, Bryndis E Gunnarsdottir, Ingibjorg Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn Unit for Nutrition Research, Landspitali-University Hospital, Reykjavík, Iceland. beb@hi.is 2008-06-25 http://hdl.handle.net/2336/30476 en eng American Society of Clinical Nutrition http://www.ajcn.org/cgi/content/abstract/76/2/399 Am. J. Clin. Nutr. 2002, 76(2):399-403 0002-9165 12145013 http://hdl.handle.net/2336/30476 American journal of clinical nutrition Adult Aged Birth Weight Blood Glucose Body Mass Index Data Collection Diabetes Mellitus Type 2 Female Glucose Intolerance Humans Iceland Infant Newborn Male Middle Aged Prevalence Randomized Controlled Trials as Topic Article 2008 ftlandspitaliuni 2022-05-29T08:21:09Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The results of epidemiologic studies have linked birth size to adult glucose intolerance. OBJECTIVE: We investigated this association in a genetically homogeneous population with higher birth weights and a lower prevalence of type 2 diabetes than previously studied. DESIGN: The subjects were 2362 men and 2286 women aged 33-65 y. Size at birth was obtained from the National Archives of Iceland. Data for adult anthropometry, fasting blood glucose, and blood glucose after an oral glucose load came from the randomized prospective Reykjavík Study. RESULTS: Postchallenge glucose concentrations were inversely related to birth weight and length in men and inversely related to birth weight and ponderal index in women (P < 0.001). This association was mainly found among those within the highest one-third of adult body mass index values. In men, the prevalence of dysglycemia was lower with increasing weight (P = 0.04) and length (P = 0.003) at birth but there was no relation of dysglycemia to ponderal index. For women, there was no linear trend for dysglycemia in relation to size at birth but the relation with birth length was U shaped. CONCLUSIONS: Greater birth weight and length appear to offer a protective effect against glucose intolerance. Adult overweight or obesity enhances the risk associated with low birth weight and length. Because the population studied has higher birth weights and a lower prevalence of type 2 diabetes than are found in neighboring countries, it is possible that decreasing the number of low-birth weight infants might help to stem the increasing prevalence of type 2 diabetes worldwide. Article in Journal/Newspaper Iceland Reykjavík Reykjavík Hirsla - Landspítali University Hospital research archive Reykjavík |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
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English |
topic |
Adult Aged Birth Weight Blood Glucose Body Mass Index Data Collection Diabetes Mellitus Type 2 Female Glucose Intolerance Humans Iceland Infant Newborn Male Middle Aged Prevalence Randomized Controlled Trials as Topic |
spellingShingle |
Adult Aged Birth Weight Blood Glucose Body Mass Index Data Collection Diabetes Mellitus Type 2 Female Glucose Intolerance Humans Iceland Infant Newborn Male Middle Aged Prevalence Randomized Controlled Trials as Topic Birgisdottir, Bryndis E Gunnarsdottir, Ingibjorg Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
topic_facet |
Adult Aged Birth Weight Blood Glucose Body Mass Index Data Collection Diabetes Mellitus Type 2 Female Glucose Intolerance Humans Iceland Infant Newborn Male Middle Aged Prevalence Randomized Controlled Trials as Topic |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The results of epidemiologic studies have linked birth size to adult glucose intolerance. OBJECTIVE: We investigated this association in a genetically homogeneous population with higher birth weights and a lower prevalence of type 2 diabetes than previously studied. DESIGN: The subjects were 2362 men and 2286 women aged 33-65 y. Size at birth was obtained from the National Archives of Iceland. Data for adult anthropometry, fasting blood glucose, and blood glucose after an oral glucose load came from the randomized prospective Reykjavík Study. RESULTS: Postchallenge glucose concentrations were inversely related to birth weight and length in men and inversely related to birth weight and ponderal index in women (P < 0.001). This association was mainly found among those within the highest one-third of adult body mass index values. In men, the prevalence of dysglycemia was lower with increasing weight (P = 0.04) and length (P = 0.003) at birth but there was no relation of dysglycemia to ponderal index. For women, there was no linear trend for dysglycemia in relation to size at birth but the relation with birth length was U shaped. CONCLUSIONS: Greater birth weight and length appear to offer a protective effect against glucose intolerance. Adult overweight or obesity enhances the risk associated with low birth weight and length. Because the population studied has higher birth weights and a lower prevalence of type 2 diabetes than are found in neighboring countries, it is possible that decreasing the number of low-birth weight infants might help to stem the increasing prevalence of type 2 diabetes worldwide. |
author2 |
Unit for Nutrition Research, Landspitali-University Hospital, Reykjavík, Iceland. beb@hi.is |
format |
Article in Journal/Newspaper |
author |
Birgisdottir, Bryndis E Gunnarsdottir, Ingibjorg Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn |
author_facet |
Birgisdottir, Bryndis E Gunnarsdottir, Ingibjorg Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn |
author_sort |
Birgisdottir, Bryndis E |
title |
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
title_short |
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
title_full |
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
title_fullStr |
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
title_full_unstemmed |
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
title_sort |
size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population |
publisher |
American Society of Clinical Nutrition |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/30476 |
geographic |
Reykjavík |
geographic_facet |
Reykjavík |
genre |
Iceland Reykjavík Reykjavík |
genre_facet |
Iceland Reykjavík Reykjavík |
op_relation |
http://www.ajcn.org/cgi/content/abstract/76/2/399 Am. J. Clin. Nutr. 2002, 76(2):399-403 0002-9165 12145013 http://hdl.handle.net/2336/30476 American journal of clinical nutrition |
_version_ |
1766039199779127296 |