Size at birth and coronary artery disease in a population with high birth weight
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Epidemiologic studies suggest a link between fetal and childhood growth and later coronary artery disease (CAD). The influence of adult body size on the relation between birth s...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/30452 2023-05-15T16:49:08+02:00 Size at birth and coronary artery disease in a population with high birth weight Gunnarsdottir, Ingibjorg Birgisdottir, Bryndis E Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn Unit for Nutrition Research, Landspitali-University Hospital, Reykjavik, Iceland. ingigun@hi.is 2008-06-25 http://hdl.handle.net/2336/30452 en eng American Society of Clinical Nutrition http://www.ajcn.org/cgi/content/abstract/76/6/1290 Am. J. Clin. Nutr. 2002, 76(6):1290-4 0002-9165 12450895 http://hdl.handle.net/2336/30452 American journal of clinical nutrition Aged Birth Weight Body Height Body Mass Index Coronary Disease Female Humans Iceland Male Middle Aged Myocardial Infarction Odds Ratio Article 2008 ftlandspitaliuni 2022-05-29T08:21:09Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Epidemiologic studies suggest a link between fetal and childhood growth and later coronary artery disease (CAD). The influence of adult body size on the relation between birth size and CAD has not been thoroughly studied. OBJECTIVE: We investigated the association between birth and adult sizes and CAD within a population with higher birth weight and a lower incidence of and mortality rate from CAD than those seen in other Scandinavian populations. DESIGN: Fatal or nonfatal CAD was ascertained in 2399 men and 2376 women born in the Greater Reykjavik area between 1914 and 1935. Birth size was obtained from the National Archives. Anthropometric measurements in adults were obtained from the randomized prospective Reykjavik Study. RESULTS: CAD was inversely related to birth length (P for trend = 0.029) in men but was not significantly related to birth weight or ponderal index (kg/m(3)). In men who were born short (< or = 50.5 cm) and who became tall adults (either 175-180.5 or > 180.5 cm), the odds ratios (95% CI) for CAD were 1.9 (1.1, 3.1) and 2.2 (1.2, 4.0), respectively, when compared with men in the reference group (those born 52.5-54.0 cm long). A U-shaped relation between birth size and CAD was found for women. CONCLUSIONS: Size at birth has an effect on CAD, but the effect is modified by adult body size. This confirms that environmental factors operate in both the prenatal and postnatal periods with regard to the development of CAD. The large birth size seen among Icelanders may explain the lower incidence and mortality rate of CAD in Iceland than are seen in other white populations. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged Birth Weight Body Height Body Mass Index Coronary Disease Female Humans Iceland Male Middle Aged Myocardial Infarction Odds Ratio |
spellingShingle |
Aged Birth Weight Body Height Body Mass Index Coronary Disease Female Humans Iceland Male Middle Aged Myocardial Infarction Odds Ratio Gunnarsdottir, Ingibjorg Birgisdottir, Bryndis E Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn Size at birth and coronary artery disease in a population with high birth weight |
topic_facet |
Aged Birth Weight Body Height Body Mass Index Coronary Disease Female Humans Iceland Male Middle Aged Myocardial Infarction Odds Ratio |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Epidemiologic studies suggest a link between fetal and childhood growth and later coronary artery disease (CAD). The influence of adult body size on the relation between birth size and CAD has not been thoroughly studied. OBJECTIVE: We investigated the association between birth and adult sizes and CAD within a population with higher birth weight and a lower incidence of and mortality rate from CAD than those seen in other Scandinavian populations. DESIGN: Fatal or nonfatal CAD was ascertained in 2399 men and 2376 women born in the Greater Reykjavik area between 1914 and 1935. Birth size was obtained from the National Archives. Anthropometric measurements in adults were obtained from the randomized prospective Reykjavik Study. RESULTS: CAD was inversely related to birth length (P for trend = 0.029) in men but was not significantly related to birth weight or ponderal index (kg/m(3)). In men who were born short (< or = 50.5 cm) and who became tall adults (either 175-180.5 or > 180.5 cm), the odds ratios (95% CI) for CAD were 1.9 (1.1, 3.1) and 2.2 (1.2, 4.0), respectively, when compared with men in the reference group (those born 52.5-54.0 cm long). A U-shaped relation between birth size and CAD was found for women. CONCLUSIONS: Size at birth has an effect on CAD, but the effect is modified by adult body size. This confirms that environmental factors operate in both the prenatal and postnatal periods with regard to the development of CAD. The large birth size seen among Icelanders may explain the lower incidence and mortality rate of CAD in Iceland than are seen in other white populations. |
author2 |
Unit for Nutrition Research, Landspitali-University Hospital, Reykjavik, Iceland. ingigun@hi.is |
format |
Article in Journal/Newspaper |
author |
Gunnarsdottir, Ingibjorg Birgisdottir, Bryndis E Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn |
author_facet |
Gunnarsdottir, Ingibjorg Birgisdottir, Bryndis E Thorsdottir, Inga Gudnason, Vilmundur Benediktsson, Rafn |
author_sort |
Gunnarsdottir, Ingibjorg |
title |
Size at birth and coronary artery disease in a population with high birth weight |
title_short |
Size at birth and coronary artery disease in a population with high birth weight |
title_full |
Size at birth and coronary artery disease in a population with high birth weight |
title_fullStr |
Size at birth and coronary artery disease in a population with high birth weight |
title_full_unstemmed |
Size at birth and coronary artery disease in a population with high birth weight |
title_sort |
size at birth and coronary artery disease in a population with high birth weight |
publisher |
American Society of Clinical Nutrition |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/30452 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ajcn.org/cgi/content/abstract/76/6/1290 Am. J. Clin. Nutr. 2002, 76(6):1290-4 0002-9165 12450895 http://hdl.handle.net/2336/30452 American journal of clinical nutrition |
_version_ |
1766039199601917952 |