Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.

• Published in: Age and Ageing
• Main Authors: Siggeirsdottir, Kristin, Aspelund, Thor, Jonsson, Brynjolfur Y, Mogensen, Brynjolfur, Launer, Lenore J, Harris, Tamara B, Sigurdsson, Gunnar, Gudnason, Vilmundur
• Other Authors: Icelandic Heart Association Research Institute, Kopavogur, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oxford University Press 2013
• Subjects: Activities of Daily Living; Age Factors; Aged; 80 and over; Aging; Biomechanics; Comorbidity; Female; Follow-Up Studies; Hospitalization; Humans; Iceland; Linear Models; Male; Muscle Strength; Osteoporosis; Proportional Hazards Models; Prospective Studies; Quality of Life; Risk Assessment; Risk Factors; Spinal Fractures; Time Factors
• Online Access: http://hdl.handle.net/2336/301397; https://doi.org/10.1093/ageing/afs003

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Understanding the determinants of health burden after a fracture in ageing populations is important. Assess the effect of clinical vertebral and other osteoporotic fractures on function and the subsequent risk of hospitalisation. Individuals from the prospective population-based cohort study Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were examined between 2002 and 2006 and followed up for 5.4 years. A total of 5,764 individuals, 57.7% women, born 1907-35, mean age 77. Method: four groups with a verified fracture status were used; vertebral fractures, other osteoporotic fractures excluding vertebral, non-osteoporotic fractures and not-fractured were compared and analysed for the effect on mobility, strength, QoL, ADL, co-morbidity and hospitalisation. Worst performance on functional tests was in the vertebral fracture group for women (P < 0.0001) and the other osteoporotic fractures group for men (P < 0.05). Both vertebral and other osteoporotic fractures, showed an increased risk of hospitalisation, HR = 1.4 (95% CI: 1.3-1.7) and 1.2 (95% CI: 1.1-1.2) respectively (P < 0.0001). Individuals with vertebral fractures had 50% (P < 0.0001) longer hospitalisation than not-fractured and 33% (P < 0.002) longer than the other osteoporotic fractures group. Individuals with a history of clinical vertebral fracture seem to carry the greatest health burden compared with other fracture groups, emphasising the attention which should be given to those individuals. National Institutes of Health, USA N01-AG-12100 National Institute on Aging Hjartavernd (The Icelandic Heart Association) Althingi (The Icelandic Parliament)