Lower mortality following coronary arterial revascularization in patients taking statins.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Numerous studies have suggested that statins have beneficial non-lipid-lowering effects, including reduction of systemic inflammatory response following surgery. We wanted to evalua...
Published in: | Scandinavian Cardiovascular Journal |
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Online Access: | http://hdl.handle.net/2336/301149 https://doi.org/10.3109/14017431.2012.719633 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/301149 2023-05-15T16:47:30+02:00 Lower mortality following coronary arterial revascularization in patients taking statins. Oddsson, Saemundur J Sigurdsson, Martin Ingi Helgadottir, Solveig Sigurjonsson, Hannes Viktorsson, Sindri Arnorsson, Thorarinn Thorgeirsson, Gudmundur Gudbjartsson, Tomas Department of Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland. 2013-09-05 http://hdl.handle.net/2336/301149 https://doi.org/10.3109/14017431.2012.719633 en eng http://dx.doi.org/10.3109/14017431.2012.719633 Scand. Cardiovasc. J. 2012, 46(6):353-8 1651-2006 22873649 doi:10.3109/14017431.2012.719633 http://hdl.handle.net/2336/301149 Scandinavian cardiovascular journal : SCJ Archived with thanks to Scandinavian cardiovascular journal : SCJ National Consortium - Landsaðgangur Aged Chi-Square Distribution Confounding Factors (Epidemiology) Coronary Artery Bypass Off-Pump Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypertension Iceland Incidence Kaplan-Meier Estimate Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Postoperative Complications Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome Article 2013 ftlandspitaliuni https://doi.org/10.3109/14017431.2012.719633 2022-05-29T08:21:52Z To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Numerous studies have suggested that statins have beneficial non-lipid-lowering effects, including reduction of systemic inflammatory response following surgery. We wanted to evaluate the effect of preoperative statin treatment on complications and operative mortality after coronary arterial revascularization. We performed a retrospective study of 720 consecutive patients who underwent on-pump coronary artery bypass grafting (CABG) (n = 513) or off-pump (OPCAB) (n = 207) in Iceland from 2002-2006. Patients taking statins preoperatively (n = 529) were compared with those not taking statins (n = 191). Predictors of complications and operative mortality were evaluated by univariate and multivariate analysis. Cardiovascular risk profiles were similar. However, hypertension was more common in the statin group but EuroSCORE was slightly lower. Operative mortality was significantly lower in patients taking statins (1.7% vs. 5.8%, p < 0.001). There were no significant differences in the incidence of major complications. Multivariate analysis showed that preoperative statin treatment was an independent predictor of lower operative mortality (OR = 0.33, p = 0.043), even after adjusting for EuroSCORE, acute operations, advanced age, or other medications. In this non- randomized study, patients taking statins had lower operative mortality than the controls after adjusting for multiple confounders. The reason for this might be linked to pleiotropic effects of statins. Landspitali University Research Fund University of Iceland Research Fund Helga Jonsdottir and Sigurlidi Kristjansson Memorial Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Scandinavian Cardiovascular Journal 46 6 353 358 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged Chi-Square Distribution Confounding Factors (Epidemiology) Coronary Artery Bypass Off-Pump Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypertension Iceland Incidence Kaplan-Meier Estimate Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Postoperative Complications Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
spellingShingle |
Aged Chi-Square Distribution Confounding Factors (Epidemiology) Coronary Artery Bypass Off-Pump Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypertension Iceland Incidence Kaplan-Meier Estimate Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Postoperative Complications Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome Oddsson, Saemundur J Sigurdsson, Martin Ingi Helgadottir, Solveig Sigurjonsson, Hannes Viktorsson, Sindri Arnorsson, Thorarinn Thorgeirsson, Gudmundur Gudbjartsson, Tomas Lower mortality following coronary arterial revascularization in patients taking statins. |
topic_facet |
Aged Chi-Square Distribution Confounding Factors (Epidemiology) Coronary Artery Bypass Off-Pump Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypertension Iceland Incidence Kaplan-Meier Estimate Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Postoperative Complications Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
description |
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Numerous studies have suggested that statins have beneficial non-lipid-lowering effects, including reduction of systemic inflammatory response following surgery. We wanted to evaluate the effect of preoperative statin treatment on complications and operative mortality after coronary arterial revascularization. We performed a retrospective study of 720 consecutive patients who underwent on-pump coronary artery bypass grafting (CABG) (n = 513) or off-pump (OPCAB) (n = 207) in Iceland from 2002-2006. Patients taking statins preoperatively (n = 529) were compared with those not taking statins (n = 191). Predictors of complications and operative mortality were evaluated by univariate and multivariate analysis. Cardiovascular risk profiles were similar. However, hypertension was more common in the statin group but EuroSCORE was slightly lower. Operative mortality was significantly lower in patients taking statins (1.7% vs. 5.8%, p < 0.001). There were no significant differences in the incidence of major complications. Multivariate analysis showed that preoperative statin treatment was an independent predictor of lower operative mortality (OR = 0.33, p = 0.043), even after adjusting for EuroSCORE, acute operations, advanced age, or other medications. In this non- randomized study, patients taking statins had lower operative mortality than the controls after adjusting for multiple confounders. The reason for this might be linked to pleiotropic effects of statins. Landspitali University Research Fund University of Iceland Research Fund Helga Jonsdottir and Sigurlidi Kristjansson Memorial Fund |
author2 |
Department of Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Oddsson, Saemundur J Sigurdsson, Martin Ingi Helgadottir, Solveig Sigurjonsson, Hannes Viktorsson, Sindri Arnorsson, Thorarinn Thorgeirsson, Gudmundur Gudbjartsson, Tomas |
author_facet |
Oddsson, Saemundur J Sigurdsson, Martin Ingi Helgadottir, Solveig Sigurjonsson, Hannes Viktorsson, Sindri Arnorsson, Thorarinn Thorgeirsson, Gudmundur Gudbjartsson, Tomas |
author_sort |
Oddsson, Saemundur J |
title |
Lower mortality following coronary arterial revascularization in patients taking statins. |
title_short |
Lower mortality following coronary arterial revascularization in patients taking statins. |
title_full |
Lower mortality following coronary arterial revascularization in patients taking statins. |
title_fullStr |
Lower mortality following coronary arterial revascularization in patients taking statins. |
title_full_unstemmed |
Lower mortality following coronary arterial revascularization in patients taking statins. |
title_sort |
lower mortality following coronary arterial revascularization in patients taking statins. |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/301149 https://doi.org/10.3109/14017431.2012.719633 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Meier |
geographic_facet |
Meier |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.3109/14017431.2012.719633 Scand. Cardiovasc. J. 2012, 46(6):353-8 1651-2006 22873649 doi:10.3109/14017431.2012.719633 http://hdl.handle.net/2336/301149 Scandinavian cardiovascular journal : SCJ |
op_rights |
Archived with thanks to Scandinavian cardiovascular journal : SCJ National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.3109/14017431.2012.719633 |
container_title |
Scandinavian Cardiovascular Journal |
container_volume |
46 |
container_issue |
6 |
container_start_page |
353 |
op_container_end_page |
358 |
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1766037599204409344 |