Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Ceruloplasmin (Cp) concentration and oxidative activity in serum are lowered in Parkinson's disease (PD). In most PD patients, iron increases in the substantia nigra in the midbrain....
Published in: | Neuropsychiatric Disease and Treatment |
---|---|
Main Authors: | , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Medical Press
2013
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/300230 https://doi.org/10.2147/NDT.S34729 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/300230 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/300230 2023-05-15T16:51:28+02:00 Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. Kristinsson, Jakob Snaedal, Jón Tórsdóttir, Gudlaug Jóhannesson, Torkell Department of Pharmacology and Toxicology, University of Iceland, Reykjavik, Iceland. 2013-08-29 http://hdl.handle.net/2336/300230 https://doi.org/10.2147/NDT.S34729 en eng Dove Medical Press http://dx.doi.org/10.2147/NDT.S34729 http://www.dovepress.com/ceruloplasmin-and-iron-in-alzheimerrsquos-disease-and-parkinsonrsquos--peer-reviewed-article-NDT http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493298/ Neuropsychiatr Dis Treat 2012, 8:515-21 1178-2021 23144563 doi:10.2147/NDT.S34729 http://hdl.handle.net/2336/300230 Neuropsychiatric disease and treatment Archived with thanks to Neuropsychiatric disease and treatment Open Access - Opinn aðgangur Article 2013 ftlandspitaliuni https://doi.org/10.2147/NDT.S34729 2022-05-29T08:21:52Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Ceruloplasmin (Cp) concentration and oxidative activity in serum are lowered in Parkinson's disease (PD). In most PD patients, iron increases in the substantia nigra in the midbrain. In PD, the low Cp concentration and activity in serum and the high iron amounts in the substantia nigra appears to be correlated. An hereditary background is common in PD and variations in the Cp gene that have been found in PD are associated with high iron levels in the substantia nigra. Variations in Cp synthesis and in the incorporation of copper into the Cp molecule are essential features of PD. In Alzheimer's disease (AD), the Cp activity in serum is lowered but not the concentration, except in the advanced stages of the disease. Generally, iron is not increased in the AD brain. In the AD brain, iron accumulates in neuritic plaques and in neurofibrillary tangles. There is also increased risk of iron-mediated tissue damage, which may possibly be counteracted by Cp. At the same time, the AD brain is short in copper, which presumably results in the deficient activity of many copper enzymes in the brain, in addition to Cp. Lowered Cp activity in serum most likely stems from lessened incorporation of copper in the Cp molecule and similar incorporation defects might also apply to other copper enzymes in AD. Scientific Fund of Helga Scientific Fund of Sigurlidi Kristjansson Scientific Fund of the University of Iceland Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Neuropsychiatric Disease and Treatment 515 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Ceruloplasmin (Cp) concentration and oxidative activity in serum are lowered in Parkinson's disease (PD). In most PD patients, iron increases in the substantia nigra in the midbrain. In PD, the low Cp concentration and activity in serum and the high iron amounts in the substantia nigra appears to be correlated. An hereditary background is common in PD and variations in the Cp gene that have been found in PD are associated with high iron levels in the substantia nigra. Variations in Cp synthesis and in the incorporation of copper into the Cp molecule are essential features of PD. In Alzheimer's disease (AD), the Cp activity in serum is lowered but not the concentration, except in the advanced stages of the disease. Generally, iron is not increased in the AD brain. In the AD brain, iron accumulates in neuritic plaques and in neurofibrillary tangles. There is also increased risk of iron-mediated tissue damage, which may possibly be counteracted by Cp. At the same time, the AD brain is short in copper, which presumably results in the deficient activity of many copper enzymes in the brain, in addition to Cp. Lowered Cp activity in serum most likely stems from lessened incorporation of copper in the Cp molecule and similar incorporation defects might also apply to other copper enzymes in AD. Scientific Fund of Helga Scientific Fund of Sigurlidi Kristjansson Scientific Fund of the University of Iceland |
author2 |
Department of Pharmacology and Toxicology, University of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Kristinsson, Jakob Snaedal, Jón Tórsdóttir, Gudlaug Jóhannesson, Torkell |
spellingShingle |
Kristinsson, Jakob Snaedal, Jón Tórsdóttir, Gudlaug Jóhannesson, Torkell Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. |
author_facet |
Kristinsson, Jakob Snaedal, Jón Tórsdóttir, Gudlaug Jóhannesson, Torkell |
author_sort |
Kristinsson, Jakob |
title |
Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. |
title_short |
Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. |
title_full |
Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. |
title_fullStr |
Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. |
title_full_unstemmed |
Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies. |
title_sort |
ceruloplasmin and iron in alzheimer's disease and parkinson's disease: a synopsis of recent studies. |
publisher |
Dove Medical Press |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/300230 https://doi.org/10.2147/NDT.S34729 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.2147/NDT.S34729 http://www.dovepress.com/ceruloplasmin-and-iron-in-alzheimerrsquos-disease-and-parkinsonrsquos--peer-reviewed-article-NDT http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493298/ Neuropsychiatr Dis Treat 2012, 8:515-21 1178-2021 23144563 doi:10.2147/NDT.S34729 http://hdl.handle.net/2336/300230 Neuropsychiatric disease and treatment |
op_rights |
Archived with thanks to Neuropsychiatric disease and treatment Open Access - Opinn aðgangur |
op_doi |
https://doi.org/10.2147/NDT.S34729 |
container_title |
Neuropsychiatric Disease and Treatment |
container_start_page |
515 |
_version_ |
1766041580807913472 |