Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Fatigue is prevalent in adult cancer survivors but less studied in childhood cancer survivors. Aims were to assess fatigue levels, prevalence of chronic fatigue (CF) and the association of...
Published in: | Pediatric Blood & Cancer |
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Online Access: | http://hdl.handle.net/2336/299932 https://doi.org/10.1002/pbc.23111 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/299932 2023-05-15T16:52:20+02:00 Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. Jóhannsdóttir, Inga M R Hjermstad, Marianne J Moum, Torbjørn Wesenberg, Finn Hjorth, Lars Schrøder, Henrik Mört, Susanna Jónmundsson, Gudmundur Loge, Jon H National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital and University of Oslo, Montebello, Oslo, Norway. 2013-08-27 http://hdl.handle.net/2336/299932 https://doi.org/10.1002/pbc.23111 en eng Wiley http://dx.doi.org/10.1002/pbc.23111 http://onlinelibrary.wiley.com/doi/10.1002/pbc.23111/pdf Pediatr Blood Cancer 2012, 58(3):415-20 1545-5017 21425447 doi:10.1002/pbc.23111 http://hdl.handle.net/2336/299932 Pediatric blood & cancer Archived with thanks to Pediatric blood & cancer Landspitali Access - LSH-aðgangur Adolescent Adult Astrocytoma Case-Control Studies Child Chronic Disease Fatigue Female Finland Health Surveys Humans Iceland Infratentorial Neoplasms Kidney Neoplasms Leukemia Myeloid Acute Male Mental Fatigue Prevalence Quality of Life Regression Analysis Scandinavia Survivors Wilms Tumor Article 2013 ftlandspitaliuni https://doi.org/10.1002/pbc.23111 2022-05-29T08:21:51Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Fatigue is prevalent in adult cancer survivors but less studied in childhood cancer survivors. Aims were to assess fatigue levels, prevalence of chronic fatigue (CF) and the association of CF with health-related quality of life (HRQoL) in survivors of acute myeloid leukemia (AML), infratentorial astrocytoma (IA), and Wilms tumor (WT) in childhood. Seventy percent (398/567) of Nordic patients treated for AML, IA, and WT between 1985 and 2001 at age >1 year responded to a postal survey, encompassing the Fatigue Questionnaire and the Short Form 36 (SF-36). Participants were divided into two groups at time of study; younger (YG, 13-18 years) and older (OG, 19-34 years). Respondents (19-34 years, n = 763) from a Norwegian general population (GP) survey served as controls for the OG. The OG [mean age was 24 years (SD 3.3)] had higher fatigue levels compared to the YG and the GP, especially the females (P < 0.05). There was also a higher prevalence of CF in the OG than in the GP (14 vs. 6%, P < 0.001). Regardless of diagnosis, the OG with CF had poorer physical health (P < 0.05) on the SF-36 but better mental health (P < 0.05 and P = 0.001) relative to controls with CF. The prevalence of CF is higher among Nordic survivors of AML, IA, and WT than GP controls of similar age. CF is associated with impaired HRQoL in survivors. However, they reported better mental health than CF GP controls. This might indicate different underlying mechanisms of CF in the two populations. Norwegian Cancer Society Nordic Cancer Union Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Pediatric Blood & Cancer 58 3 415 420 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Astrocytoma Case-Control Studies Child Chronic Disease Fatigue Female Finland Health Surveys Humans Iceland Infratentorial Neoplasms Kidney Neoplasms Leukemia Myeloid Acute Male Mental Fatigue Prevalence Quality of Life Regression Analysis Scandinavia Survivors Wilms Tumor |
spellingShingle |
Adolescent Adult Astrocytoma Case-Control Studies Child Chronic Disease Fatigue Female Finland Health Surveys Humans Iceland Infratentorial Neoplasms Kidney Neoplasms Leukemia Myeloid Acute Male Mental Fatigue Prevalence Quality of Life Regression Analysis Scandinavia Survivors Wilms Tumor Jóhannsdóttir, Inga M R Hjermstad, Marianne J Moum, Torbjørn Wesenberg, Finn Hjorth, Lars Schrøder, Henrik Mört, Susanna Jónmundsson, Gudmundur Loge, Jon H Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
topic_facet |
Adolescent Adult Astrocytoma Case-Control Studies Child Chronic Disease Fatigue Female Finland Health Surveys Humans Iceland Infratentorial Neoplasms Kidney Neoplasms Leukemia Myeloid Acute Male Mental Fatigue Prevalence Quality of Life Regression Analysis Scandinavia Survivors Wilms Tumor |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Fatigue is prevalent in adult cancer survivors but less studied in childhood cancer survivors. Aims were to assess fatigue levels, prevalence of chronic fatigue (CF) and the association of CF with health-related quality of life (HRQoL) in survivors of acute myeloid leukemia (AML), infratentorial astrocytoma (IA), and Wilms tumor (WT) in childhood. Seventy percent (398/567) of Nordic patients treated for AML, IA, and WT between 1985 and 2001 at age >1 year responded to a postal survey, encompassing the Fatigue Questionnaire and the Short Form 36 (SF-36). Participants were divided into two groups at time of study; younger (YG, 13-18 years) and older (OG, 19-34 years). Respondents (19-34 years, n = 763) from a Norwegian general population (GP) survey served as controls for the OG. The OG [mean age was 24 years (SD 3.3)] had higher fatigue levels compared to the YG and the GP, especially the females (P < 0.05). There was also a higher prevalence of CF in the OG than in the GP (14 vs. 6%, P < 0.001). Regardless of diagnosis, the OG with CF had poorer physical health (P < 0.05) on the SF-36 but better mental health (P < 0.05 and P = 0.001) relative to controls with CF. The prevalence of CF is higher among Nordic survivors of AML, IA, and WT than GP controls of similar age. CF is associated with impaired HRQoL in survivors. However, they reported better mental health than CF GP controls. This might indicate different underlying mechanisms of CF in the two populations. Norwegian Cancer Society Nordic Cancer Union |
author2 |
National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital and University of Oslo, Montebello, Oslo, Norway. |
format |
Article in Journal/Newspaper |
author |
Jóhannsdóttir, Inga M R Hjermstad, Marianne J Moum, Torbjørn Wesenberg, Finn Hjorth, Lars Schrøder, Henrik Mört, Susanna Jónmundsson, Gudmundur Loge, Jon H |
author_facet |
Jóhannsdóttir, Inga M R Hjermstad, Marianne J Moum, Torbjørn Wesenberg, Finn Hjorth, Lars Schrøder, Henrik Mört, Susanna Jónmundsson, Gudmundur Loge, Jon H |
author_sort |
Jóhannsdóttir, Inga M R |
title |
Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
title_short |
Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
title_full |
Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
title_fullStr |
Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
title_full_unstemmed |
Increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
title_sort |
increased prevalence of chronic fatigue among survivors of childhood cancers: a population-based study. |
publisher |
Wiley |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/299932 https://doi.org/10.1002/pbc.23111 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1002/pbc.23111 http://onlinelibrary.wiley.com/doi/10.1002/pbc.23111/pdf Pediatr Blood Cancer 2012, 58(3):415-20 1545-5017 21425447 doi:10.1002/pbc.23111 http://hdl.handle.net/2336/299932 Pediatric blood & cancer |
op_rights |
Archived with thanks to Pediatric blood & cancer Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1002/pbc.23111 |
container_title |
Pediatric Blood & Cancer |
container_volume |
58 |
container_issue |
3 |
container_start_page |
415 |
op_container_end_page |
420 |
_version_ |
1766042497469906944 |