Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study).
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section...
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Online Access: | http://hdl.handle.net/2336/299930 https://doi.org/10.1007/s00223-012-9585-6 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/299930 2023-05-15T16:51:49+02:00 Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). Johannesdottir, Fjola Aspelund, Thor Siggeirsdottir, Kristin Jonsson, Brynjolfur Y Mogensen, Brynjolfur Sigurdsson, Sigurdur Harris, Tamara B Gudnason, Vilmundur G Lang, Thomas F Sigurdsson, Gunnar University of Iceland, Reykjavik, Iceland. Landspitali 2013-08-27 http://hdl.handle.net/2336/299930 https://doi.org/10.1007/s00223-012-9585-6 en eng Springer Verlag http://dx.doi.org/10.1007/s00223-012-9585-6 http://link.springer.com/content/pdf/10.1007%2Fs00223-012-9585-6.pdf Calcif. Tissue Int. 2012, 90(5):354-64 1432-0827 22451219 doi:10.1007/s00223-012-9585-6 http://hdl.handle.net/2336/299930 Calcified tissue international Archived with thanks to Calcified tissue international National Consortium - Landsaðgangur Aged 80 and over Bone Density Cohort Studies Female Femur Follow-Up Studies Fractures Bone Humans Lower Extremity Male Muscle Skeletal Sex Factors Article 2013 ftlandspitaliuni https://doi.org/10.1007/s00223-012-9585-6 2022-05-29T08:21:51Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained <10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns. NIH N01-AG-1-2100 NIA Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament) memorial fund of Helga Jonsdottir and Sigurlidi Kristjansson University of Iceland Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Calcified Tissue International 90 5 354 364 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Bone Density Cohort Studies Female Femur Follow-Up Studies Fractures Bone Humans Lower Extremity Male Muscle Skeletal Sex Factors |
spellingShingle |
Aged 80 and over Bone Density Cohort Studies Female Femur Follow-Up Studies Fractures Bone Humans Lower Extremity Male Muscle Skeletal Sex Factors Johannesdottir, Fjola Aspelund, Thor Siggeirsdottir, Kristin Jonsson, Brynjolfur Y Mogensen, Brynjolfur Sigurdsson, Sigurdur Harris, Tamara B Gudnason, Vilmundur G Lang, Thomas F Sigurdsson, Gunnar Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). |
topic_facet |
Aged 80 and over Bone Density Cohort Studies Female Femur Follow-Up Studies Fractures Bone Humans Lower Extremity Male Muscle Skeletal Sex Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained <10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns. NIH N01-AG-1-2100 NIA Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament) memorial fund of Helga Jonsdottir and Sigurlidi Kristjansson University of Iceland |
author2 |
University of Iceland, Reykjavik, Iceland. Landspitali |
format |
Article in Journal/Newspaper |
author |
Johannesdottir, Fjola Aspelund, Thor Siggeirsdottir, Kristin Jonsson, Brynjolfur Y Mogensen, Brynjolfur Sigurdsson, Sigurdur Harris, Tamara B Gudnason, Vilmundur G Lang, Thomas F Sigurdsson, Gunnar |
author_facet |
Johannesdottir, Fjola Aspelund, Thor Siggeirsdottir, Kristin Jonsson, Brynjolfur Y Mogensen, Brynjolfur Sigurdsson, Sigurdur Harris, Tamara B Gudnason, Vilmundur G Lang, Thomas F Sigurdsson, Gunnar |
author_sort |
Johannesdottir, Fjola |
title |
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). |
title_short |
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). |
title_full |
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). |
title_fullStr |
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). |
title_full_unstemmed |
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). |
title_sort |
mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (ages-reykjavik study). |
publisher |
Springer Verlag |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/299930 https://doi.org/10.1007/s00223-012-9585-6 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1007/s00223-012-9585-6 http://link.springer.com/content/pdf/10.1007%2Fs00223-012-9585-6.pdf Calcif. Tissue Int. 2012, 90(5):354-64 1432-0827 22451219 doi:10.1007/s00223-012-9585-6 http://hdl.handle.net/2336/299930 Calcified tissue international |
op_rights |
Archived with thanks to Calcified tissue international National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1007/s00223-012-9585-6 |
container_title |
Calcified Tissue International |
container_volume |
90 |
container_issue |
5 |
container_start_page |
354 |
op_container_end_page |
364 |
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1766041923851649024 |