A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded...
Published in: | Nature Genetics |
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Online Access: | http://hdl.handle.net/2336/299065 https://doi.org/10.1038/ng.2437 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/299065 2023-05-15T16:52:20+02:00 A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Masson, Gisli Agnarsson, Bjarni A Benediktsdottir, Kristrun R Sigurdsson, Asgeir Magnusson, Olafur Th Gudjonsson, Sigurjon A Magnusdottir, Droplaug N Johannsdottir, Hrefna Helgadottir, Hafdis Th Stacey, Simon N Jonasdottir, Adalbjorg Olafsdottir, Stefania B Thorleifsson, Gudmar Jonasson, Jon G Tryggvadottir, Laufey Navarrete, Sebastian Fuertes, Fernando Helfand, Brian T Hu, Qiaoyan Csiki, Irma E Mates, Ioan N Jinga, Viorel Aben, Katja K H van Oort, Inge M Vermeulen, Sita H Donovan, Jenny L Hamdy, Freddy C Ng, Chi-Fai Chiu, Peter K F Lau, Kin-Mang Ng, Maggie C Y Gulcher, Jeffrey R Kong, Augustine Catalona, William J Mayordomo, Jose I Einarsson, Gudmundur V Barkardottir, Rosa B Jonsson, Eirikur Mates, Dana Neal, David E Kiemeney, Lambertus A Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari deCODE genetics, Reykjavik, Iceland. 2013-08-19 http://hdl.handle.net/2336/299065 https://doi.org/10.1038/ng.2437 en eng http://dx.doi.org/10.1038/ng.2437 Nat. Genet. 2012, 44(12):1326-9 1546-1718 23104005 doi:10.1038/ng.2437 http://hdl.handle.net/2336/299065 Nature genetics Archived with thanks to Nature genetics Landspitali Access - LSH-aðgangur Adenocarcinoma Aged 80 and over Base Sequence Cell Line Chromosomes Human Pair 8 European Continental Ancestry Group Gene Frequency Genetic Predisposition to Disease Genome Genome-Wide Association Study Homeodomain Proteins Humans Iceland Male Middle Aged Molecular Sequence Data Mutation Polymorphism Single Nucleotide Prostatic Neoplasms Risk Sequence Analysis DNA Article 2013 ftlandspitaliuni https://doi.org/10.1038/ng.2437 2022-05-29T08:21:51Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous common variants conferring risk of prostate cancer. Here, we analyzed 32.5 million variants discovered by whole-genome sequencing 1,795 Icelanders. We identified a new low-frequency variant at 8q24 associated with prostate cancer in European populations, rs188140481[A] (odds ratio (OR) = 2.90; P(combined) = 6.2 × 10(-34)), with an average risk allele frequency in controls of 0.54%. This variant is only very weakly correlated (r(2) ≤ 0.06) with previously reported risk variants at 8q24, and its association remains significant after adjustment for all known risk-associated variants. Carriers of rs188140481[A] were diagnosed with prostate cancer 1.26 years younger than non-carriers (P = 0.0059). We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe. European Union 202059 Urological Research Foundation U01 CA089600 P50 CA90386 P30 CA60553 Health Technology Assessment Programme 96/20/06 96/20/99 Department of Health, England Cancer Research UK C522/A8649 Medical Research Council of England G0500966_ID-75466 National Cancer Research Institute (NCRI), UK Southwest National Health Service Research and Development NCRI (ProMPT) study Cambridge and Oxford British Medical Research Council grants from the National Institute for Health Research Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 44 12 1326 1329 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adenocarcinoma Aged 80 and over Base Sequence Cell Line Chromosomes Human Pair 8 European Continental Ancestry Group Gene Frequency Genetic Predisposition to Disease Genome Genome-Wide Association Study Homeodomain Proteins Humans Iceland Male Middle Aged Molecular Sequence Data Mutation Polymorphism Single Nucleotide Prostatic Neoplasms Risk Sequence Analysis DNA |
spellingShingle |
Adenocarcinoma Aged 80 and over Base Sequence Cell Line Chromosomes Human Pair 8 European Continental Ancestry Group Gene Frequency Genetic Predisposition to Disease Genome Genome-Wide Association Study Homeodomain Proteins Humans Iceland Male Middle Aged Molecular Sequence Data Mutation Polymorphism Single Nucleotide Prostatic Neoplasms Risk Sequence Analysis DNA Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Masson, Gisli Agnarsson, Bjarni A Benediktsdottir, Kristrun R Sigurdsson, Asgeir Magnusson, Olafur Th Gudjonsson, Sigurjon A Magnusdottir, Droplaug N Johannsdottir, Hrefna Helgadottir, Hafdis Th Stacey, Simon N Jonasdottir, Adalbjorg Olafsdottir, Stefania B Thorleifsson, Gudmar Jonasson, Jon G Tryggvadottir, Laufey Navarrete, Sebastian Fuertes, Fernando Helfand, Brian T Hu, Qiaoyan Csiki, Irma E Mates, Ioan N Jinga, Viorel Aben, Katja K H van Oort, Inge M Vermeulen, Sita H Donovan, Jenny L Hamdy, Freddy C Ng, Chi-Fai Chiu, Peter K F Lau, Kin-Mang Ng, Maggie C Y Gulcher, Jeffrey R Kong, Augustine Catalona, William J Mayordomo, Jose I Einarsson, Gudmundur V Barkardottir, Rosa B Jonsson, Eirikur Mates, Dana Neal, David E Kiemeney, Lambertus A Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
topic_facet |
Adenocarcinoma Aged 80 and over Base Sequence Cell Line Chromosomes Human Pair 8 European Continental Ancestry Group Gene Frequency Genetic Predisposition to Disease Genome Genome-Wide Association Study Homeodomain Proteins Humans Iceland Male Middle Aged Molecular Sequence Data Mutation Polymorphism Single Nucleotide Prostatic Neoplasms Risk Sequence Analysis DNA |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous common variants conferring risk of prostate cancer. Here, we analyzed 32.5 million variants discovered by whole-genome sequencing 1,795 Icelanders. We identified a new low-frequency variant at 8q24 associated with prostate cancer in European populations, rs188140481[A] (odds ratio (OR) = 2.90; P(combined) = 6.2 × 10(-34)), with an average risk allele frequency in controls of 0.54%. This variant is only very weakly correlated (r(2) ≤ 0.06) with previously reported risk variants at 8q24, and its association remains significant after adjustment for all known risk-associated variants. Carriers of rs188140481[A] were diagnosed with prostate cancer 1.26 years younger than non-carriers (P = 0.0059). We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe. European Union 202059 Urological Research Foundation U01 CA089600 P50 CA90386 P30 CA60553 Health Technology Assessment Programme 96/20/06 96/20/99 Department of Health, England Cancer Research UK C522/A8649 Medical Research Council of England G0500966_ID-75466 National Cancer Research Institute (NCRI), UK Southwest National Health Service Research and Development NCRI (ProMPT) study Cambridge and Oxford British Medical Research Council grants from the National Institute for Health Research |
author2 |
deCODE genetics, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Masson, Gisli Agnarsson, Bjarni A Benediktsdottir, Kristrun R Sigurdsson, Asgeir Magnusson, Olafur Th Gudjonsson, Sigurjon A Magnusdottir, Droplaug N Johannsdottir, Hrefna Helgadottir, Hafdis Th Stacey, Simon N Jonasdottir, Adalbjorg Olafsdottir, Stefania B Thorleifsson, Gudmar Jonasson, Jon G Tryggvadottir, Laufey Navarrete, Sebastian Fuertes, Fernando Helfand, Brian T Hu, Qiaoyan Csiki, Irma E Mates, Ioan N Jinga, Viorel Aben, Katja K H van Oort, Inge M Vermeulen, Sita H Donovan, Jenny L Hamdy, Freddy C Ng, Chi-Fai Chiu, Peter K F Lau, Kin-Mang Ng, Maggie C Y Gulcher, Jeffrey R Kong, Augustine Catalona, William J Mayordomo, Jose I Einarsson, Gudmundur V Barkardottir, Rosa B Jonsson, Eirikur Mates, Dana Neal, David E Kiemeney, Lambertus A Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari |
author_facet |
Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Masson, Gisli Agnarsson, Bjarni A Benediktsdottir, Kristrun R Sigurdsson, Asgeir Magnusson, Olafur Th Gudjonsson, Sigurjon A Magnusdottir, Droplaug N Johannsdottir, Hrefna Helgadottir, Hafdis Th Stacey, Simon N Jonasdottir, Adalbjorg Olafsdottir, Stefania B Thorleifsson, Gudmar Jonasson, Jon G Tryggvadottir, Laufey Navarrete, Sebastian Fuertes, Fernando Helfand, Brian T Hu, Qiaoyan Csiki, Irma E Mates, Ioan N Jinga, Viorel Aben, Katja K H van Oort, Inge M Vermeulen, Sita H Donovan, Jenny L Hamdy, Freddy C Ng, Chi-Fai Chiu, Peter K F Lau, Kin-Mang Ng, Maggie C Y Gulcher, Jeffrey R Kong, Augustine Catalona, William J Mayordomo, Jose I Einarsson, Gudmundur V Barkardottir, Rosa B Jonsson, Eirikur Mates, Dana Neal, David E Kiemeney, Lambertus A Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari |
author_sort |
Gudmundsson, Julius |
title |
A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
title_short |
A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
title_full |
A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
title_fullStr |
A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
title_full_unstemmed |
A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
title_sort |
study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/299065 https://doi.org/10.1038/ng.2437 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/ng.2437 Nat. Genet. 2012, 44(12):1326-9 1546-1718 23104005 doi:10.1038/ng.2437 http://hdl.handle.net/2336/299065 Nature genetics |
op_rights |
Archived with thanks to Nature genetics Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1038/ng.2437 |
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Nature Genetics |
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