Jaundice due to suspected statin hepatotoxicity: a case series.
Statin drugs are widely used worldwide and are generally considered safe and well tolerated. Only small proportion of patients receiving statins develop elevations of liver enzymes and an even smaller proportion will have clinically significant hepatitis induced by statins. We describe four patients...
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Online Access: | http://hdl.handle.net/2336/295200 https://doi.org/10.1007/s10620-011-1950-1 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/295200 2023-05-15T16:47:24+02:00 Jaundice due to suspected statin hepatotoxicity: a case series. Bergmann, Ottar M Kristjansson, Gudjon Jonasson, Jon G Björnsson, Einar S Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital of Iceland, Reykjavik, Iceland. 2013-07-04 http://hdl.handle.net/2336/295200 https://doi.org/10.1007/s10620-011-1950-1 en eng http://dx.doi.org/10.1007/s10620-011-1950-1 Dig Dis Sci 2012, 57(7):1959-64 1573-2568 22075853 doi:10.1007/s10620-011-1950-1 http://hdl.handle.net/2336/295200 Digestive diseases and sciences Archived with thanks to Digestive diseases and sciences National Consortium - Landsaðgangur Aged 80 and over Biopsy Dose-Response Relationship Drug Drug-Induced Liver Injury Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Jaundice Liver Male Middle Aged Article 2013 ftlandspitaliuni https://doi.org/10.1007/s10620-011-1950-1 2022-05-29T08:21:51Z Statin drugs are widely used worldwide and are generally considered safe and well tolerated. Only small proportion of patients receiving statins develop elevations of liver enzymes and an even smaller proportion will have clinically significant hepatitis induced by statins. We describe four patients with jaundice caused by drug-induced liver injury, where the most likely agent was a statin drug, over a period of approximately three year in Iceland. We calculate the risk of jaundice caused by statin drugs, from sale in the whole country of Iceland, to be one in 17,434 users a year. This is a higher risk than has previously been estimated and we challenge the current opinion that statins rarely cause clinically significant drug-induced liver injury and encourage alertness when managing patients with statins with regard to clinical signs of hepatitis before jaundice occurs. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Digestive Diseases and Sciences 57 7 1959 1964 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Biopsy Dose-Response Relationship Drug Drug-Induced Liver Injury Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Jaundice Liver Male Middle Aged |
spellingShingle |
Aged 80 and over Biopsy Dose-Response Relationship Drug Drug-Induced Liver Injury Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Jaundice Liver Male Middle Aged Bergmann, Ottar M Kristjansson, Gudjon Jonasson, Jon G Björnsson, Einar S Jaundice due to suspected statin hepatotoxicity: a case series. |
topic_facet |
Aged 80 and over Biopsy Dose-Response Relationship Drug Drug-Induced Liver Injury Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Jaundice Liver Male Middle Aged |
description |
Statin drugs are widely used worldwide and are generally considered safe and well tolerated. Only small proportion of patients receiving statins develop elevations of liver enzymes and an even smaller proportion will have clinically significant hepatitis induced by statins. We describe four patients with jaundice caused by drug-induced liver injury, where the most likely agent was a statin drug, over a period of approximately three year in Iceland. We calculate the risk of jaundice caused by statin drugs, from sale in the whole country of Iceland, to be one in 17,434 users a year. This is a higher risk than has previously been estimated and we challenge the current opinion that statins rarely cause clinically significant drug-induced liver injury and encourage alertness when managing patients with statins with regard to clinical signs of hepatitis before jaundice occurs. |
author2 |
Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Bergmann, Ottar M Kristjansson, Gudjon Jonasson, Jon G Björnsson, Einar S |
author_facet |
Bergmann, Ottar M Kristjansson, Gudjon Jonasson, Jon G Björnsson, Einar S |
author_sort |
Bergmann, Ottar M |
title |
Jaundice due to suspected statin hepatotoxicity: a case series. |
title_short |
Jaundice due to suspected statin hepatotoxicity: a case series. |
title_full |
Jaundice due to suspected statin hepatotoxicity: a case series. |
title_fullStr |
Jaundice due to suspected statin hepatotoxicity: a case series. |
title_full_unstemmed |
Jaundice due to suspected statin hepatotoxicity: a case series. |
title_sort |
jaundice due to suspected statin hepatotoxicity: a case series. |
publishDate |
2013 |
url |
http://hdl.handle.net/2336/295200 https://doi.org/10.1007/s10620-011-1950-1 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1007/s10620-011-1950-1 Dig Dis Sci 2012, 57(7):1959-64 1573-2568 22075853 doi:10.1007/s10620-011-1950-1 http://hdl.handle.net/2336/295200 Digestive diseases and sciences |
op_rights |
Archived with thanks to Digestive diseases and sciences National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1007/s10620-011-1950-1 |
container_title |
Digestive Diseases and Sciences |
container_volume |
57 |
container_issue |
7 |
container_start_page |
1959 |
op_container_end_page |
1964 |
_version_ |
1766037485743243264 |