Association of symptoms of colon cancer patients with tumor location and TNM tumor stage.
Colon cancer is the second most common cause of cancer death in Iceland and accounts for 8% of malignancies. We related information on symptoms of colon cancer patients with information on tumor location and pTNM-stage. The study is retrospective and population-based. Information on all patients dia...
Published in: | Scandinavian Journal of Gastroenterology |
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Online Access: | http://hdl.handle.net/2336/295061 https://doi.org/10.3109/00365521.2012.672589 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/295061 2023-05-15T16:47:30+02:00 Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. Alexiusdottir, Kristin K Möller, Pall Helgi Snaebjornsson, Petur Jonasson, Larus Olafsdottir, Elinborg J Björnsson, Einar Stefan Tryggvadottir, Laufey Jonasson, Jon G Landspitali University Hospital and Faculty of Medicine, University of Iceland, Iceland. 2012-07-02 http://hdl.handle.net/2336/295061 https://doi.org/10.3109/00365521.2012.672589 en eng http://dx.doi.org/10.3109/00365521.2012.672589 Scand. J. Gastroenterol. 2012, 47 (7):795-801 1502-7708 22506981 doi:10.3109/00365521.2012.672589 http://hdl.handle.net/2336/295061 Scandinavian journal of gastroenterology Archived with thanks to Scandinavian journal of gastroenterology Landspitali Access - LSH-aðgangur Abdominal Pain Aged Anemia Chi-Square Distribution Colon Colonic Neoplasms Defecation Female Gastrointestinal Hemorrhage Hemoglobins Humans Iceland Incidental Findings Male Middle Aged Multivariate Analysis Neoplasm Staging Odds Ratio Retrospective Studies Article 2012 ftlandspitaliuni https://doi.org/10.3109/00365521.2012.672589 2022-05-29T08:21:51Z Colon cancer is the second most common cause of cancer death in Iceland and accounts for 8% of malignancies. We related information on symptoms of colon cancer patients with information on tumor location and pTNM-stage. The study is retrospective and population-based. Information on all patients diagnosed with colon cancer in Iceland in 1995-2004 was obtained. Information on symptoms of patients and blood hemoglobin was collected from patients' files. The pathological parameters were derived from a previously performed study. A total of 768 patients (422 males, 346 females) participated in this study. Median age was 73 years. Nearly 60% had anemia at the time of diagnosis, 53% had visible blood in stools, and 65% had changes in bowel habits. Around 84% had visible blood in stools and/or anemia. Of those with right-sided tumors, 75% had anemia and were more likely to be diagnosed incidentally (40%) than those with left-sided tumors (20%). Left-sided tumors were associated with blood in stools (68% compared to 41%, p < 0.05) and changes in bowel habits (74% compared to 57%, p < 0.05). Multivariate analysis indicated that blood in stools was strongly associated with a lower TNM-stage (OR = 0.75, p < 0.05). Anemia was strongly associated with a higher TNM-stage (OR = 1.84, p < 0.05). Right-sided tumors were associated with anemia and incidental diagnosis; left-sided tumors were associated with visible blood in stools and changes in bowel habits. Visible blood in stools was significantly associated with lower TNM-stage, whereas abdominal pain, general and acute symptoms were associated with higher TNM-stage. Landspitali University Hospital Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) Scandinavian Journal of Gastroenterology 47 7 795 801 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Abdominal Pain Aged Anemia Chi-Square Distribution Colon Colonic Neoplasms Defecation Female Gastrointestinal Hemorrhage Hemoglobins Humans Iceland Incidental Findings Male Middle Aged Multivariate Analysis Neoplasm Staging Odds Ratio Retrospective Studies |
spellingShingle |
Abdominal Pain Aged Anemia Chi-Square Distribution Colon Colonic Neoplasms Defecation Female Gastrointestinal Hemorrhage Hemoglobins Humans Iceland Incidental Findings Male Middle Aged Multivariate Analysis Neoplasm Staging Odds Ratio Retrospective Studies Alexiusdottir, Kristin K Möller, Pall Helgi Snaebjornsson, Petur Jonasson, Larus Olafsdottir, Elinborg J Björnsson, Einar Stefan Tryggvadottir, Laufey Jonasson, Jon G Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. |
topic_facet |
Abdominal Pain Aged Anemia Chi-Square Distribution Colon Colonic Neoplasms Defecation Female Gastrointestinal Hemorrhage Hemoglobins Humans Iceland Incidental Findings Male Middle Aged Multivariate Analysis Neoplasm Staging Odds Ratio Retrospective Studies |
description |
Colon cancer is the second most common cause of cancer death in Iceland and accounts for 8% of malignancies. We related information on symptoms of colon cancer patients with information on tumor location and pTNM-stage. The study is retrospective and population-based. Information on all patients diagnosed with colon cancer in Iceland in 1995-2004 was obtained. Information on symptoms of patients and blood hemoglobin was collected from patients' files. The pathological parameters were derived from a previously performed study. A total of 768 patients (422 males, 346 females) participated in this study. Median age was 73 years. Nearly 60% had anemia at the time of diagnosis, 53% had visible blood in stools, and 65% had changes in bowel habits. Around 84% had visible blood in stools and/or anemia. Of those with right-sided tumors, 75% had anemia and were more likely to be diagnosed incidentally (40%) than those with left-sided tumors (20%). Left-sided tumors were associated with blood in stools (68% compared to 41%, p < 0.05) and changes in bowel habits (74% compared to 57%, p < 0.05). Multivariate analysis indicated that blood in stools was strongly associated with a lower TNM-stage (OR = 0.75, p < 0.05). Anemia was strongly associated with a higher TNM-stage (OR = 1.84, p < 0.05). Right-sided tumors were associated with anemia and incidental diagnosis; left-sided tumors were associated with visible blood in stools and changes in bowel habits. Visible blood in stools was significantly associated with lower TNM-stage, whereas abdominal pain, general and acute symptoms were associated with higher TNM-stage. Landspitali University Hospital |
author2 |
Landspitali University Hospital and Faculty of Medicine, University of Iceland, Iceland. |
format |
Article in Journal/Newspaper |
author |
Alexiusdottir, Kristin K Möller, Pall Helgi Snaebjornsson, Petur Jonasson, Larus Olafsdottir, Elinborg J Björnsson, Einar Stefan Tryggvadottir, Laufey Jonasson, Jon G |
author_facet |
Alexiusdottir, Kristin K Möller, Pall Helgi Snaebjornsson, Petur Jonasson, Larus Olafsdottir, Elinborg J Björnsson, Einar Stefan Tryggvadottir, Laufey Jonasson, Jon G |
author_sort |
Alexiusdottir, Kristin K |
title |
Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. |
title_short |
Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. |
title_full |
Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. |
title_fullStr |
Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. |
title_full_unstemmed |
Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. |
title_sort |
association of symptoms of colon cancer patients with tumor location and tnm tumor stage. |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/295061 https://doi.org/10.3109/00365521.2012.672589 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
geographic |
TNM |
geographic_facet |
TNM |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.3109/00365521.2012.672589 Scand. J. Gastroenterol. 2012, 47 (7):795-801 1502-7708 22506981 doi:10.3109/00365521.2012.672589 http://hdl.handle.net/2336/295061 Scandinavian journal of gastroenterology |
op_rights |
Archived with thanks to Scandinavian journal of gastroenterology Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.3109/00365521.2012.672589 |
container_title |
Scandinavian Journal of Gastroenterology |
container_volume |
47 |
container_issue |
7 |
container_start_page |
795 |
op_container_end_page |
801 |
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1766037599040831488 |