Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field AIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the ef...
Published in: | Diabetologia |
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Online Access: | http://hdl.handle.net/2336/29503 https://doi.org/10.1007/s00125-008-1035-7 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/29503 2023-05-15T16:52:20+02:00 Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults Ramel, A Martinéz, A Kiely, M Morais, G Bandarra, NM Thorsdottir, I Unit for Nutrition Research, Landspitali-University Hospital & Faculty of Food Science and Nutrition, Eiriksgata 29, 101, Reykjavik, Iceland. 2008-06-04 http://hdl.handle.net/2336/29503 https://doi.org/10.1007/s00125-008-1035-7 ENG en eng Springer Verlag http://www.springerlink.com/content/c0062871xx1v4272 Diabetologia. 2008, 51(7):1261-68 0012-186X 18491071 doi:10.1007/s00125-008-1035-7 http://hdl.handle.net/2336/29503 Diabetologia Fatty Acids Omega-3 Insulin Resistance Weight Loss Diet Reducing Article 2008 ftlandspitaliuni https://doi.org/10.1007/s00125-008-1035-7 2022-05-29T08:21:07Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field AIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction. METHODS: In this 8 week dietary intervention, 324 participants (20-40 years, BMI 27.5-32.5 kg/m(2), from Iceland, Spain and Ireland) were randomised by computer to one of four energy-restricted diets (-30E%) of identical macronutrient composition but different LC n-3 PUFA content: control (n = 80; no seafood; single-blinded); lean fish (n = 80; 150 g cod, three times/week); fatty fish (n = 84; 150 g salmon, three times/week); (4) fish oil (n = 80; daily docosahexaenoic/eicosapentaenoic acid capsules, no other seafood; single-blinded). Fasting glucose, insulin, adiponectin, plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group. RESULTS: Of the participants, 278 (86%) completed the intervention. Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis. Weight loss was also a significant predictor of improvements. CONCLUSIONS/INTERPRETATION: LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Diabetologia 51 7 1261 1268 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Fatty Acids Omega-3 Insulin Resistance Weight Loss Diet Reducing |
spellingShingle |
Fatty Acids Omega-3 Insulin Resistance Weight Loss Diet Reducing Ramel, A Martinéz, A Kiely, M Morais, G Bandarra, NM Thorsdottir, I Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults |
topic_facet |
Fatty Acids Omega-3 Insulin Resistance Weight Loss Diet Reducing |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field AIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction. METHODS: In this 8 week dietary intervention, 324 participants (20-40 years, BMI 27.5-32.5 kg/m(2), from Iceland, Spain and Ireland) were randomised by computer to one of four energy-restricted diets (-30E%) of identical macronutrient composition but different LC n-3 PUFA content: control (n = 80; no seafood; single-blinded); lean fish (n = 80; 150 g cod, three times/week); fatty fish (n = 84; 150 g salmon, three times/week); (4) fish oil (n = 80; daily docosahexaenoic/eicosapentaenoic acid capsules, no other seafood; single-blinded). Fasting glucose, insulin, adiponectin, plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group. RESULTS: Of the participants, 278 (86%) completed the intervention. Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis. Weight loss was also a significant predictor of improvements. CONCLUSIONS/INTERPRETATION: LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte ... |
author2 |
Unit for Nutrition Research, Landspitali-University Hospital & Faculty of Food Science and Nutrition, Eiriksgata 29, 101, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Ramel, A Martinéz, A Kiely, M Morais, G Bandarra, NM Thorsdottir, I |
author_facet |
Ramel, A Martinéz, A Kiely, M Morais, G Bandarra, NM Thorsdottir, I |
author_sort |
Ramel, A |
title |
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults |
title_short |
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults |
title_full |
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults |
title_fullStr |
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults |
title_full_unstemmed |
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults |
title_sort |
beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese european young adults |
publisher |
Springer Verlag |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/29503 https://doi.org/10.1007/s00125-008-1035-7 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.springerlink.com/content/c0062871xx1v4272 Diabetologia. 2008, 51(7):1261-68 0012-186X 18491071 doi:10.1007/s00125-008-1035-7 http://hdl.handle.net/2336/29503 Diabetologia |
op_doi |
https://doi.org/10.1007/s00125-008-1035-7 |
container_title |
Diabetologia |
container_volume |
51 |
container_issue |
7 |
container_start_page |
1261 |
op_container_end_page |
1268 |
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1766042474429546496 |