Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open OBJECTIVE: Fluoroquinolones are bacteriocidal drugs that are widely used to treat severe urinary and respiratory tract infections. Studies show that resistance to fluoroquinolones is continuously increas...
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Læknafélag Íslands, Læknafélag Reykjavíkur
2008
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Online Access: | http://hdl.handle.net/2336/29343 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/29343 2023-05-15T16:49:39+02:00 Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun Quinolone resistance in Gram negative rods in Iceland and association with antibiotic use Kristín Jónsdóttir Karl G. Kristinsson 2008-06-02 http://hdl.handle.net/2336/29343 ice is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is Læknablaðið 2008, 94(4):279-85 0023-7213 18460726 http://hdl.handle.net/2336/29343 Læknablaðið Lyfjanotkun Sýklalyf Ónæmi Adolescent Adult Anti-Bacterial Agents Child Preschool Ciprofloxacin Drug Resistance Bacterial Drug Utilization Escherichia coli Female Fluoroquinolones Gram-Negative Aerobic Rods and Cocci Gram-Negative Facultatively Anaerobic Rods Iceland Infant Newborn Klebsiella Male Middle Aged Proteus Pseudomonas aeruginosa Time Factors Article 2008 ftlandspitaliuni 2022-05-29T08:21:07Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open OBJECTIVE: Fluoroquinolones are bacteriocidal drugs that are widely used to treat severe urinary and respiratory tract infections. Studies show that resistance to fluoroquinolones is continuously increasing both in Europe and the United States. The purpose of this study was to measure the frequency of fluoroquinolone resistance in the most prevalent Gram negative rods and look at the correlation with fluoroquinolone use over the last 8 years. MATERIALS AND METHODS: All strains of Escherichia coli, Klebsiella sp., Proteus sp. and Pseudomonas aeruginosa identified from clinical specimens at the Department of Clinical Microbiology at the Landspitali University Hospital (LUH) during the time period 1.11.2006 to 31.1.2007. Antibiotic susceptibility testing was performed by disc diffusion tests and all strains were tested for ciprofloxacin susceptibility. Antibiotic resistance data for the last years were collected from the reports of the Department of Clinical Microbiology, but ciprofloxacin susceptibility was usually only tested for specimens from hospitalised patients and when there was resistance to two or more antimicrobial agents. Data on antibiotic use/sales was obtained from the State Epidemiologist at the Directorate of Health. RESULTS: Of the 1861 strains tested, 104 fluoroquinolone resistant strains were identified during the study period, including 91 E. coli (87%), 8 Klebsiella sp. (8%) and 5 P. aeruginosa (5%). No fluoroquinolone resistant Proteus sp. was identified. There was a significant positive correlation between fluoroquinolone use and the frequency of resistant strains of E. coli and Enterobacteriaceae. The frequency of resistant E. coli strains was 6% and it differed significantly between age groups (p >0.001) and sex, 6% for females and 11% for males (p = 0.015). The ratio of fluoroquinolone resistant E. coli was highest in the LUH and homes for the elderly. CONCLUSION: The frequency of ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Lyfjanotkun Sýklalyf Ónæmi Adolescent Adult Anti-Bacterial Agents Child Preschool Ciprofloxacin Drug Resistance Bacterial Drug Utilization Escherichia coli Female Fluoroquinolones Gram-Negative Aerobic Rods and Cocci Gram-Negative Facultatively Anaerobic Rods Iceland Infant Newborn Klebsiella Male Middle Aged Proteus Pseudomonas aeruginosa Time Factors |
spellingShingle |
Lyfjanotkun Sýklalyf Ónæmi Adolescent Adult Anti-Bacterial Agents Child Preschool Ciprofloxacin Drug Resistance Bacterial Drug Utilization Escherichia coli Female Fluoroquinolones Gram-Negative Aerobic Rods and Cocci Gram-Negative Facultatively Anaerobic Rods Iceland Infant Newborn Klebsiella Male Middle Aged Proteus Pseudomonas aeruginosa Time Factors Kristín Jónsdóttir Karl G. Kristinsson Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun |
topic_facet |
Lyfjanotkun Sýklalyf Ónæmi Adolescent Adult Anti-Bacterial Agents Child Preschool Ciprofloxacin Drug Resistance Bacterial Drug Utilization Escherichia coli Female Fluoroquinolones Gram-Negative Aerobic Rods and Cocci Gram-Negative Facultatively Anaerobic Rods Iceland Infant Newborn Klebsiella Male Middle Aged Proteus Pseudomonas aeruginosa Time Factors |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open OBJECTIVE: Fluoroquinolones are bacteriocidal drugs that are widely used to treat severe urinary and respiratory tract infections. Studies show that resistance to fluoroquinolones is continuously increasing both in Europe and the United States. The purpose of this study was to measure the frequency of fluoroquinolone resistance in the most prevalent Gram negative rods and look at the correlation with fluoroquinolone use over the last 8 years. MATERIALS AND METHODS: All strains of Escherichia coli, Klebsiella sp., Proteus sp. and Pseudomonas aeruginosa identified from clinical specimens at the Department of Clinical Microbiology at the Landspitali University Hospital (LUH) during the time period 1.11.2006 to 31.1.2007. Antibiotic susceptibility testing was performed by disc diffusion tests and all strains were tested for ciprofloxacin susceptibility. Antibiotic resistance data for the last years were collected from the reports of the Department of Clinical Microbiology, but ciprofloxacin susceptibility was usually only tested for specimens from hospitalised patients and when there was resistance to two or more antimicrobial agents. Data on antibiotic use/sales was obtained from the State Epidemiologist at the Directorate of Health. RESULTS: Of the 1861 strains tested, 104 fluoroquinolone resistant strains were identified during the study period, including 91 E. coli (87%), 8 Klebsiella sp. (8%) and 5 P. aeruginosa (5%). No fluoroquinolone resistant Proteus sp. was identified. There was a significant positive correlation between fluoroquinolone use and the frequency of resistant strains of E. coli and Enterobacteriaceae. The frequency of resistant E. coli strains was 6% and it differed significantly between age groups (p >0.001) and sex, 6% for females and 11% for males (p = 0.015). The ratio of fluoroquinolone resistant E. coli was highest in the LUH and homes for the elderly. CONCLUSION: The frequency of ... |
format |
Article in Journal/Newspaper |
author |
Kristín Jónsdóttir Karl G. Kristinsson |
author_facet |
Kristín Jónsdóttir Karl G. Kristinsson |
author_sort |
Kristín Jónsdóttir |
title |
Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun |
title_short |
Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun |
title_full |
Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun |
title_fullStr |
Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun |
title_full_unstemmed |
Ónæmi fyrir kínólónum hjá Gram neikvæðum stöfum á Íslandi og tengsl við sýklalyfjanotkun |
title_sort |
ónæmi fyrir kínólónum hjá gram neikvæðum stöfum á íslandi og tengsl við sýklalyfjanotkun |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/29343 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Smella |
geographic_facet |
Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is Læknablaðið 2008, 94(4):279-85 0023-7213 18460726 http://hdl.handle.net/2336/29343 Læknablaðið |
_version_ |
1766039795357712384 |