Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Psoriasis is a chronic inflammatory skin disease with overlapping subphenotypes. It has a strong complex genetic component, but has been problematic to identifying significant loci. We eval...
Published in: | Journal of Investigative Dermatology |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2857 2023-05-15T16:48:32+02:00 Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci Karason, Ari Gudjonsson, Johann E Jonsson, Hjortur H Hauksson, Valdimar B Runarsdottir, E Hjaltey Stefansson, Kari Valdimarsson, Helgi Gulcher, Jeffrey R 2005 YES http://hdl.handle.net/2336/2857 https://doi.org/10.1111/j.0022-202X.2005.23703.x en eng Nature http://www.nature.com/jid/journal/v124/n6/full/5602846a.html J. Invest. Dermatol. 2005, 124(6):1177-85 0022-202X 15955092 doi:10.1111/j.0022-202X.2005.23703.x AAI12 http://hdl.handle.net/2336/2857 Journal of investigative dermatology Age of Onset Arthritis Psoriatic Chromosome Mapping Chromosomes Human Pair 16 Pair 4 Cohort Studies Female Iceland Linkage (Genetics) Lod Score Major Histocompatibility Complex Nails Phenotype Psoriasis Scalp Dermatoses Skin Wounds and Injuries Article 2005 ftlandspitaliuni https://doi.org/10.1111/j.0022-202X.2005.23703.x 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Psoriasis is a chronic inflammatory skin disease with overlapping subphenotypes. It has a strong complex genetic component, but has been problematic to identifying significant loci. We evaluated 1000 patients with chronic plaque psoriasis and documented several subphenotypes. Here we report results of genome-wide linkage scans for psoriasis genes in 238 Icelandic families with 874 patients. MHC linkage was confirmed with LOD score of 10.9. When the entire cohort was analyzed, two other loci with LOD scores of 2.5 and 1.5 were observed on 16q and 4q, respectively. Stratification into subphenotypes revealed additional loci with LOD scores exceeding or approaching significance. A LOD score of 5.7 appeared on 16q in PsA patients with analysis conditioned on parental inheritance. A LOD score of 3.6 on 4q was detected when disease occurred at or older than 17 y, our median cohort age. This locus was defined by a marker near one reportedly displaying significant linkage in a Chinese psoriasis population and near suggestive linkage in a Caucasian population. A LOD of 3.0 was observed on 10q when disease onset occurred in the scalp. Furthermore, clinical stratification either revealed or increased LOD scores when compared to unstratified analysis and some coincided with previous reports. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Journal of Investigative Dermatology 124 6 1177 1185 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Age of Onset Arthritis Psoriatic Chromosome Mapping Chromosomes Human Pair 16 Pair 4 Cohort Studies Female Iceland Linkage (Genetics) Lod Score Major Histocompatibility Complex Nails Phenotype Psoriasis Scalp Dermatoses Skin Wounds and Injuries |
spellingShingle |
Age of Onset Arthritis Psoriatic Chromosome Mapping Chromosomes Human Pair 16 Pair 4 Cohort Studies Female Iceland Linkage (Genetics) Lod Score Major Histocompatibility Complex Nails Phenotype Psoriasis Scalp Dermatoses Skin Wounds and Injuries Karason, Ari Gudjonsson, Johann E Jonsson, Hjortur H Hauksson, Valdimar B Runarsdottir, E Hjaltey Stefansson, Kari Valdimarsson, Helgi Gulcher, Jeffrey R Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci |
topic_facet |
Age of Onset Arthritis Psoriatic Chromosome Mapping Chromosomes Human Pair 16 Pair 4 Cohort Studies Female Iceland Linkage (Genetics) Lod Score Major Histocompatibility Complex Nails Phenotype Psoriasis Scalp Dermatoses Skin Wounds and Injuries |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Psoriasis is a chronic inflammatory skin disease with overlapping subphenotypes. It has a strong complex genetic component, but has been problematic to identifying significant loci. We evaluated 1000 patients with chronic plaque psoriasis and documented several subphenotypes. Here we report results of genome-wide linkage scans for psoriasis genes in 238 Icelandic families with 874 patients. MHC linkage was confirmed with LOD score of 10.9. When the entire cohort was analyzed, two other loci with LOD scores of 2.5 and 1.5 were observed on 16q and 4q, respectively. Stratification into subphenotypes revealed additional loci with LOD scores exceeding or approaching significance. A LOD score of 5.7 appeared on 16q in PsA patients with analysis conditioned on parental inheritance. A LOD score of 3.6 on 4q was detected when disease occurred at or older than 17 y, our median cohort age. This locus was defined by a marker near one reportedly displaying significant linkage in a Chinese psoriasis population and near suggestive linkage in a Caucasian population. A LOD of 3.0 was observed on 10q when disease onset occurred in the scalp. Furthermore, clinical stratification either revealed or increased LOD scores when compared to unstratified analysis and some coincided with previous reports. |
format |
Article in Journal/Newspaper |
author |
Karason, Ari Gudjonsson, Johann E Jonsson, Hjortur H Hauksson, Valdimar B Runarsdottir, E Hjaltey Stefansson, Kari Valdimarsson, Helgi Gulcher, Jeffrey R |
author_facet |
Karason, Ari Gudjonsson, Johann E Jonsson, Hjortur H Hauksson, Valdimar B Runarsdottir, E Hjaltey Stefansson, Kari Valdimarsson, Helgi Gulcher, Jeffrey R |
author_sort |
Karason, Ari |
title |
Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci |
title_short |
Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci |
title_full |
Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci |
title_fullStr |
Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci |
title_full_unstemmed |
Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci |
title_sort |
genetics of psoriasis in iceland: evidence for linkage of subphenotypes to distinct loci |
publisher |
Nature |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2857 https://doi.org/10.1111/j.0022-202X.2005.23703.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.nature.com/jid/journal/v124/n6/full/5602846a.html J. Invest. Dermatol. 2005, 124(6):1177-85 0022-202X 15955092 doi:10.1111/j.0022-202X.2005.23703.x AAI12 http://hdl.handle.net/2336/2857 Journal of investigative dermatology |
op_doi |
https://doi.org/10.1111/j.0022-202X.2005.23703.x |
container_title |
Journal of Investigative Dermatology |
container_volume |
124 |
container_issue |
6 |
container_start_page |
1177 |
op_container_end_page |
1185 |
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1766038608831053824 |